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| 1 | Synthesis and in vitro biological evaluation of thiosulfinate derivatives ,for the treatment of human multidrug-resistant breast cancer显示文摘从瞀或蒜之类蔬菜导出的 Organosulfur 混合物长为各种各样的治疗学的效果被认出了,包括 anticancer 活动。蒜素,大蒜的主要生物学上活跃的部件之一,作为一个 anticancer 代理人显示出诺言;然而,不稳定性做它为临床的申请不合适。这研究的目的是在 vitro 在人的乳癌房间上调查稳定的蒜素衍生物的效果。在这研究, 22 稳定的 thiosulfinate 衍生物的一个总数被综合并且屏蔽为他们的在里面 vitro antiproliferative 活动对药敏感(MCF-7 ) 并且 multidrug 抵抗(MCF-7/Dx ) 人的腺癌乳癌房间。为房间死亡, apoptosis,房间周期前进和 mitochondrial bioenergetic 功能的试金被执行。七混合物(4b, 7b, 8b, 13b, 14b, 15b 和 18b ) 比蒜素对 MCF-7/Dx 房间显示出更大的 antiproliferative 活动。这些混合物也是选择的向 multidrug 抵抗(MDR ) 房间,归因于并行的敏感的后果。在他们之中, 13b 在 MCF-7/Dx 和 MCF-7 房间展出了最大的 anticancer 活动,与 18.54 的 IC 50 | Ariane ROSEBLADE Alison UNG Mary BEBAWY | 2017 | Acta Pharmacologica Sinica2017，38，10： | 3 |
| 2 | Stability-Indicating Method for the Determination of Some Cephalosporines in the Presence of Degradation Products 显示文摘 | Bebawy L I Kelani Khadiga Abdel Fattah Laila | 1997 | Spectrosc Lett1997，30，2： | 1 |
| 3 | Fluorimetric determination of some antibiotics in raw material and dosage forms through ternary complex formantion with terbium(Tb3+)显示文摘 | Bebawy LI Kelani KE Fattah LA | 2003 | Journal of Pharmaceutical and Biomedical Analysis2003，32，6： | 1 |
| 4 | Multiple dosing of simvastatin inhibits airway mucus production of epithelial ceils : implications in the treatment of chronic obstructive airway pathologies 显示文摘 | Marin L Traini D Bebawy M | 2013 | Eur J Pharrn Biopharm2013，84，3： | 1 |
| 5 | Inhibition of the mul- tidrug resistance P-glycoprotein: Time for a change of strategy? 显示文摘 | Callaghan R1 Luk F Bebawy M | 2014 | Drug Metab Dispos2014，42，4： | 1 |
| 6 | Application of TLC-densitometry, first-derivative UV-spectrophotometry and ratio derivative spectrophotometry for the determination of dorzolamide hydrochloride and timolol maleate 显示文摘 | BEBAWY L I | 2002 | J Pharm Biomed Anal2002，27，5： | 1 |
| 7 | Rocuronium bromide显示文摘 | Bebawy JF | 2011 | Anesthesiology2011，114，6： | 1 |
| 8 | Specific reversal of multidrug resistance to colchicine in CEM/VLB100 cells by Gynostemma pentaphyllum extract显示文摘 | Huang T W Bebawy M Tran V H | 2007 | Phytomedicine2007，14，12： | 1 |
| 9 | Giant incisional hernia:staged repair using pneumoperitoneum and expanded polytetrafluoroethylene显示文摘 | Bebawi MA Moqtaderi F Vijay V | 1997 | Am Surg1997，63，： | 1 |
| 10 | Chronic obstructive pulmona- ry disease: patho-physiology, current methods of treatment and the potential for simvastatin in disease management 显示文摘 | Marin L Colombo P Bebawy M | 2011 | Expert Opin Drug Deliv2011，8，9： | 1 |
| 11 | The effect offurosemide on intravascular volume status and electrolytesin patients receiving mannitol : an intraoperative safety a-nalysis显示文摘 | Bebawy J F Kamaiah V K Zeeni C | 2013 | J Neurosurg Anesthesiol2013，25，1： | 1 |
| 12 | Curcumin and its Derivatives: Their Application in Neuropharmacology and Neuroscience in the 21~tCentury显示文摘 | LEE WH LOO CY BEBAWY M | 2013 | Curr Neurophar- macol2013，11，4： | 1 |
| 13 | Dynamic and intracellular trafficking of P-glycoprotein-EGFP fusion protein:Implications in multidrug resistance in multidrug resistance in cancer显示文摘 | D Fu M Bebawy EP Kable | 2004 | Int J Cancer2004，109，2： | 1 |
| 14 | Nicardipine is superior to esmolol for the management of postcraniotomy emergence hyper- tension: a randomized open - label study 显示文摘 | Bebawy JF Houston CC Kosky JL | 2015 | Anesth Analg2015，120，1： | 1 |
| 15 | Rocuronium Bromide 显示文摘 | Bebawy JF | 2011 | Anesthesiology2011，114，6： | 1 |
| 16 | The effect of furosemide on intravascular volume status and electrolytes in patients receiving mannitol: an intraoperative safety analysis显示文摘 | Bebawy JF Ramaiah VK Zeeni C | 2013 | J Neurosurg Anesthesiol2013，25，： | 1 |
| 17 | Novel potentiometric application for the determination of amprolium HCl in its single and combined dosage form and in chicken liver显示文摘Three novel amprolium HCl(AMP)-selective electrodes were investigated with 2-nitrophenyl octylether as a plasticiser in a polymeric matrix of polyvinyl chloride(PVC). Sensor I was fabricated using potassium tetrakis(4-chlorophenyl) borate(Tp ClPB) as a cationic exchanger without incorporation of an ionophore.Sensor Ⅱ used 2-hydroxy propyl β-cyclodextrin as an ionophore while sensor Ⅲ used p-tert-butylcalix[8]arene as an ionophore. The three proposed sensors showed Nernestian response slopes of 29.2±0.8,29.3±0.6 and 30.2±0.4 m V/decade over the concentration range from 10–6 to 10–2 mol L_(-1),respectively. The proposed sensors displayed useful analytical characteristics for the determination of AMP in bulk powder, different pharmaceutical formulations, and chicken liver and in the presence of ethopabate. The proposed method was validated according to ICH guidelines for its linearity, accuracy,precision and robustness. | Mai A. Basha Mohamed K. Abd El-Rahman Lories I. Bebawy Maissa Y. Salem | 2017 | Chinese Chemical Letters2017，28，3： | 1 |
| 18 | Fluorimetric Determination of Some Antibiotics in Raw Material and Dosage Forms Through Ternary Complex Formation with Terbium(Tb3+)显示文摘 | Kelani K E l Fattah L A | 2003 | J Pharm Biomed Anal2003，32，6： | 1 |
| 19 | Gender difference in P-glycoprotein expression and function: effects on drug disposition and outcome 显示文摘 | Bebawy M Cherty M | 2009 | Curt Drug Metab2009，10，： | 1 |
| 20 | Effects of irrigation frequency on germination and on root and shoot yields of Acacia spe- cies显示文摘 | Bebawi F F Mohamed S M | 1982 | Plant and Soil1982，，65： | 1 |
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