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| 1 | Role of LPS/CD14/TLR4-mediated inflammation in necrotizing enterocolitis:Pathogenesis and therapeutic implications显示文摘AIM:To establish the roles of lipopolysaccharide (LPS)/CD14/toll-like receptor 4 (TLR4)-mediated inflammation in a rat model of human necrotizing enterocolitis (NEC).METHODS: Six pairs of intestinal samples from human NEC were collected before and after recovery for histological and molecular analysis of inflammatory cytokines and signaling components. In the rat NEC model, we isolated 10-cm jejunum segments and divided them into six groups (n=6) for sham operation, treatment with LPS, bowel distension, combined bowel distension and LPS stimulation, and two therapeutic groups. The potential eff icacy of a recombinant CD18 peptide and a monoclonal CD14 antibody was evaluated in the latter two groups. The serum and tissue levels of several inflammatory mediators were quantified by real-time polymerase chain reaction, ELISA and immunoblotting.RESULTS: Human acute phase NEC tissues displayed significant increases (P<0.05) in levels of TLR4, CD14, myeloid differentiation protein (MD)-2, tumor necrosis factor (TNF)-α and nuclear factor-κB when compared to those after recovery. The histological and inflammatory picture of human NEC was reproduced in rats that were treated with combined bowel distension and LPS, but not in the sham-operated and other control rats. Serum levels of interleukin-6 and TNF-α were also elevated. The NEC pathology was attenuated by treating the NEC rats with a monoclonal CD14 antibody or an LPS-neutralizing peptide.CONCLUSION:LPS and distension are required to produce the histological and inflammatory features of NEC. A potential treatment option is blocking LPS activation and leukocyte infi ltration. | Kwong L Chan Kwong F Wong John M Luk | 2009 | World Journal of Gastroenterology2009，15，38： | 17 |
| 2 | Generalized Derivation of Lie Algebras 显示文摘 | George F Leger Eugene M Luks | 2000 | J Algebra2000，228，： | 2 |
| 3 | Molecular cytogenetic analysis of non-small cell lung carcinoma by spectral karyotyping and comparative genomic hybridization 显示文摘 | Luk C Tsao M- S Bayani J Shepherd F Squire JA | 2001 | Cancer Genetics and Cytogenetics2001，125，： | 1 |
| 4 | Injury-induced sequential transformation of notochordal nucleus pulposus to chondrogenic and fibrocartilaginous phenotype in the mouse显示文摘 | Yang F Leung VY Luk KD | 2009 | J Pathol2009，218，： | 1 |
| 5 | Controllable porosity hydroxyapatite ceramics as spine cage:fabrication and properties evaluation显示文摘 | Lu WW Zhao F Luk KDK | 2003 | J Mater Sci Mater Med2003，14，12： | 1 |
| 6 | Warm compaction offers high density at low cost显示文摘 | RUTZ H HANEJKO F LUK S | 1994 | Metal Powder Report1994，49，9： | 1 |
| 7 | Threshold Contrast Ratio and Masking Ability of Porcelain Veneers with High-density Alumina Cores显示文摘 | Chu F C Sham A S Luk H W | 2004 | Int J Prosthodont2004，17，： | 1 |
| 8 | Host cell egress and invasion in- duce marked relocations of glycolytic enzy-mes in Toxoplasma gondii tachyzoites 显示文摘 | Pome! S Luk F C Beckers C J | 2008 | PLoS Pathog2008，4，10： | 1 |
| 9 | Controllable porosity hydroxyapatite ceramics as spine cage:fabrication and properties evaluation显示文摘 | Lu WW Zhao F Luk KD | 2003 | Jmater Sci Mater Med2003，14，12： | 1 |
| 10 | Structure-function analysis of the human interferon gamma:the COOH terminus is not essential for functional activity显示文摘 | LUK S K JAY E JAY F T | 1990 | J Biol Chem1990，265，13： | 1 |
| 11 | Time-frequency feature of intraoperative somatosensory evoked potential signals显示文摘 | Hu Y Jiang F Luk KD | 2007 | Conf Proc IEEE Eng Med Biol Soc2007，1，： | 1 |
| 12 | Mesenchymal stem cells ar- rest intervertebral disc degeneration through chondrocyte di{ferentiation and stimulation of endogenous cells显示文摘 | Yang F Leung VY Luk KD | 2009 | Spine2009，，： | 1 |
| 13 | Inhibition of the mul- tidrug resistance P-glycoprotein: Time for a change of strategy? 显示文摘 | Callaghan R1 Luk F Bebawy M | 2014 | Drug Metab Dispos2014，42，4： | 1 |
| 14 | Warm compaction offers high density at lower cost 显示文摘 | Rutz H G Hanejko F G Luk S H | 1994 | Metal Powder Report1994，49，9： | 1 |
| 15 | Warm compaction of- fers high density at low cost 显示文摘 | Rutz H G Hanejko F G Luk S H | 1994 | Metal Powder Report1994，49，9： | 1 |
| 16 | Leaves of Bauhinia blakeana as indicatorsof atmospheric pollution in Hong Kong显示文摘 | LAU O W LUK S F | 2001 | AtmosphericEnvironment2001，35，： | 1 |
| 17 | Incidence of contralateral inguinal hernia显示文摘 | Tackett L D Breuer C K Luks F I er al | 1999 | J Pediatr Surg1999，34，5： | 1 |
| 18 | Warm compaction offers high density at low cost显示文摘 | Rutz H G Hanejko F G Luk S H | 1994 | Metal Powder Report1994，49，9： | 1 |
| 19 | Experimental study of a microstrip patch antenna with an L-shaped probe 显示文摘 | MAK C L LUK K M LEE K F | 2000 | IEEE Transactions on Antennas Propag2000，48，5： | 1 |
| 20 | Complication of lvmphangiomas in children显示文摘 | Hancock B J Dickens S V Luks F I | 1992 | J Pediatr Surg1992，27，2： | 1 |
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