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| 1 | Hypertriglyceridemia-induced pancreatitis: A case-based review显示文摘Hypertriglyceridemia is an established cause of pancreatitis. In a case-based approach, we present a review of hypertriglyceridemia and how it can cause pancreatitis. We outline how to investigate and manage such patients. A 35 year old man presented to the emergency department with abdominal pain and biochemical evidence of acute pancreatitis. There was no history of alcohol consumption and biliary imaging was normal. The only relevant past medical history was that of mild hyperlipidemia, treated with diet alone. Physical exam revealed epigastric tenderness, right lateral rectus palsy, lipemia retinalis, bitemporal hemianopsia and a delay in the relaxation phase of his ankle reflexes. Subsequent laboratory investigation revealed marked hypertriglyceridemia and panhypopituarism. An enhanced CT scan of the head revealed a large suprasellar mass impinging on the optic chiasm and hypothalamus. The patient was treated supportively; thyroid replacement and lipid lowering agents were started. He underwent a successful resection of a craniopharyngioma. Post- operatively, the patient did well on hormone replacement therapy. He has had no further attacks of pancreatitis. This case highlights many of the factors involved in the regulation of triglyceride metabolism. We review the common causes of hypertriglyceridemia and the proposed mechanisms resulting in pancreatitis. The incidence and management of hypertriglyceridemia- induced pancreatitis are also discussed. | S Ian Gan Alun L Edwards Christopher J Symonds Paul L Beck | 2006 | World Journal of Gastroenterology2006，12，44： | 35 |
| 2 | Hematopoietic cell transplantation for Crohn’s disease;is it time?显示文摘AIM: To review all studies in the literature that have assessed Hematopoietic cell transplantation (HCT) and Crohn’s disease (CD) with the ultimate aims of determining if this is a viable treatment option for those with CD. A secondary aim was to review the above literature and determine if the studies shed further light on the mechanisms involved in the pathogenesis of CD. METHODS: An extensive Medline search was performed on all articles from 1970 to 2005 using the ; bone marrow transplant, stem cell, hematopoietic cell, Crohn’s disease and inflammatory bowel disease. RESULTS: We identified one case in which a patient developed CD following an allogeneic HCT from a sibling suffering with CD. Evidence for transfer of the genetic predisposition to develop CD was also identified with report of a patient that developed severe CD following an allogeneic HCT. Following HCT it was found that the donor (that had no signs or symptoms of CD) and the recipient had several haplotype mismatches in HLA class Ⅲ genes in the IBD3 locus including a polymorphism of NOD2/CARD15 that has been associated with CD. Thirty three published cases of patients with CD who underwent either autologous or allogeneic HCT were identified. At the time of publication 29 of these 33 patients were considered to be in remission. The median follow-up time was seven years, and twenty months for allogeneic and autologous HCT respectively.For patients who underwent HCT primarily for treatment of their CD there have been no mortalities related to transplant complications. CONCLUSION: Overall these preliminary data suggest that both allogeneic and autologous HCT may be effective in inducing remission in refractory CD. Thissupports the hypothesis that the hematolymphatic cells play a key role in CD and that resetting of the immune system may be a critical approach in the management or cure of CD. | Y Leung M Geddes J Storek R Panaccione PL Beck | 2006 | World Journal of Gastroenterology2006，12，41： | 5 |
| 3 | Interleukin:a common endogenous mediator of information and the local shwqrtzman reaction显示文摘 | Beck G Habicht G S Benach J L | 1986 | J Immunol1986，136，： | 2 |
| 4 | New approximations for reliability integrals显示文摘 | Polidori D C Beck J L Papadimitriou C | 1999 | Internat J Engng Mech ASCE1999，125，4： | 1 |
| 5 | A new family of mesoporous molecular sieves prepared with liquid crystal templates 显示文摘 | Beck J S Vartuli J C Ruth W J | 1992 | Journal of American Chemical Society1992，114，10： | 1 |
| 6 | Analysis of estrogenic activity in coastal surface waters of the Baltic Sea using the yeast estrogen screen 显示文摘 | Beck I C Bruhn R Gandrass J | 2006 | Chemosphere2006，63，11： | 1 |
| 7 | A new family of mesoporous molecular sieves prepared with liquid crystal templates 显示文摘 | Beck J Vartuli J C Roth W J | 1992 | Journal of The American Chemical Society1992，114，10： | 1 |
| 8 | Three-dimensional rotational angiography guidance for aneurysm surgery 显示文摘 | Raabe A Beck J Rohde S | 2006 | J Neurosurg2006，105，3： | 1 |
| 9 | Inspiratory muscle unloading by neurally adjusted ventilatory assist during maximal inspiratory efforts in healthy subjects 显示文摘 | Sinderby C Beck J Spahija J | 2007 | Chest2007，131，3： | 1 |
| 10 | Thermal property estimation utilizing the laplace transform with application to asphaltic pavement 显示文摘 | Kavianipour A Beck J V | 1977 | International Journal of Heat Mass Transfer1977，20，3： | 1 |
| 11 | What To Do (and Not To Do) with Time -Series Cross -Section Data显示文摘 | BECK N KATZ J N | 1995 | American Political Journal Re- view1995，89，： | 1 |
| 12 | The squid G onatus fabricii(Lichtenstein),investigations in the Norwegian Sea and the Western Barents Sea,February-September1980and July-September1981显示文摘 | Wiborg K F Gjùster J Beck I M | 1982 | Fisken Havet1982，19，1： | 1 |
| 13 | Determination of methanol by gas- liquid chromatography显示文摘 | CAGGIANO G BECK J E | 1963 | J AOAC lnt1963，46，： | 1 |
| 14 | A new family of mesoporous molecular sieve prepared with liquid crystal templates显示文摘 | Beck J S Vartuli J C Roth W J | 1992 | J Am Chem Soc1992，114，10： | 1 |
| 15 | Design of driven piles in sand 显示文摘 | Randolph M F Dolwin J Beck R | 1994 | Geotechnique1994，44，3： | 1 |
| 16 | Factors affecting efficiency of biomass fermentation to ethanol显示文摘 | Beck M J | 1986 | Biotechnol Bioeng1986，17，： | 1 |
| 17 | Interferon gamma induces retrograde dendritic retraction and inhibits synapse formation显示文摘 | Kim I J Beck H N Lein P J | 2002 | Neurosci2002，22，11： | 1 |
| 18 | The sensitivity of singlestrand conformation polymorphism analysis for the detection of single base substitutions显示文摘 | Sheffield V C Beck J S Kwitek A E | 1993 | Genomics1993，16，： | 1 |
| 19 | Investigation of groundwater flow in karst areas using component separation of natu- ral potential measurement显示文摘 | Zhou Wangfang Barry F Beck J Brad Stephenson | 1999 | Environmental Geology1999，37，12： | 1 |
| 20 | First excursion probabilities for linearsystems by very efficient importance sampling显示文摘 | Au S K Beck J L | 2001 | Probabilistic Engineering Mechanics2001，16，19： | 1 |
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