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| 1 | Relationship between intestinal microbiota and ulcerative colitis:Mechanisms and clinical application of probiotics and fecal microbiota transplantation显示文摘Ulcerative colitis(UC) is an inflammatory disease that mainly affects the colon and rectum. It is believed that genetic factors, host immune system disorders, intestinal microbiota dysbiosis, and environmental factors contribute to the pathogenesis of UC. however, studies on the role of intestinal microbiota in the pathogenesis of UC have been inconclusive. Studies have shown that probiotics improve intestinal mucosa barrier function and immune system function and promote secretion of anti-inflammatory factors, thereby inhibiting the growth of harmful bacteria in the intestine. Fecal microbiota transplantation(FMT) can reduce bowel permeability and thus the severity of disease by increasing the production of short-chain fatty acids, especially butyrate, which help maintain the integrity of the epithelial barrier. FMT can also restore immune dysbiosis by inhibiting Th1 differentiation, activity of T cells, leukocyte adhesion, and production of inflammatory factors. Probiotics and FMT are being increasingly used to treat UC, but their use is controversial because of uncertain efficacy. Here, we briefly review the role of intestinal microbiota in thepathogenesis and treatment of UC. | Zhao-hua Shen Chang-xin Zhu Yong-sheng Quan Zhen-yu Yang Shuai Wu Wei-wei Luo Bei Tan Xiao-yan Wang | 2018 | World Journal of Gastroenterology2018，24，1： | 111 |
| 2 | Notch signaling mediated by TGF-β/Smad pathway in concanavalin A-induced liver fibrosis in rats显示文摘AIM To explore the exact interaction between Notch and transforming growth factor(TGF)-β signaling in liver fibrosis. METHODS We established a rat model of liver fibrosis induced by concanavalin A. Peripheral blood mononuclear cells(PBMCs) were isolated from the modeled rats, and cultured with γ-secretase inhibitor DAPT and TGF-β inhibitor for 24 h. The m RNA levels of Notch and TGF-β signaling were detected by quantitative real-time polymerase chain reaction. Expression of Notch and TGF-β proteins was analyzed by western blotting.RESULTS Compared to control rats, Notch and TGF-β signaling was activated in PBMCs of model rats. Administration of DAPT and TGF-β inhibitor suppressed Notch and TGF-β signal transducer in PBMCs of model rats. DAPT reduced m RNA and protein expression of TGF-β signaling, such as TGF-β1 and Smad3. TGF-β inhibitor also downregulated Notch1, Hes1 and Hes5, and m RNA and protein expression of the Notch signaling pathway.CONCLUSION Notch and TGF-β signaling play a role in liver fibrosis. TGF-β signaling upregulates Notch signaling, which promotes TGF-β signaling. | Yi Wang Ruo-Wu Shen Bing Han Zhen Li Le Xiong Feng-Yu Zhang Bei-Bei Cong Bei Zhang | 2017 | World Journal of Gastroenterology2017，23，13： | 25 |
| 3 | Performance and comparison of assessment models to predict 30-day mortality in patients with hospital-acquired pneumonia显示文摘Background:Hospital-acquired pneumonia(HAP)is the most common hospital-acquired infection in China with substantial morbidity and mortality.But no specific risk assessment model has been well validated in patients with HAP.The aim of this study was to investigate the published risk assessment models that could potentially be used to predict 30-day mortality in HAP patients in non-surgical departments.Methods:This study was a single-center,retrospective study.In total,223 patients diagnosed with HAP from 2012 to 2017 were included in this study.Clinical and laboratory data during the initial 24 hours after HAP diagnosis were collected to calculate the pneumonia severity index(PSI);consciousness,urea nitrogen,respiratory rate,blood pressure,and age≥65 years(CURB-65);Acute Physiology and Chronic Health Evaluation II(APACHE II);Sequential Organ Failure Assessment(SOFA);and Quick Sequential Organ Failure Assessment(qSOFA)scores.The discriminatory power was tested by constructing receiver operating characteristic(ROC)curves,and the areas under the curve(AUCs)were calculated.Results:The all-cause 30-day mortality rate was 18.4%(41/223).The PSI,CURB-65,SOFA,APACHE II,and qSOFA scores were significantly higher in non-survivors than in survivors(all P<0.001).The discriminatory abilities of the APACHE II and SOFA scores were better than those of the CURB-65 and qSOFA scores(ROC AUC:APACHE II vs.CURB-65,0.863 vs.0.744,Z=3.055,P=0.002;APACHE II vs.qSOFA,0.863 vs.0.767,Z=3.017,P=0.003;SOFA vs.CURB-65,0.856 vs.0.744,Z=2.589,P=0.010;SOFA vs.qSOFA,0.856 vs.0.767,Z=2.170,P=0.030).The cut-off values we defined for the SOFA,APACHE II,and qSOFA scores were 4,14,and 1.Conclusions:These results suggest that the APACHE II and SOFA scores determined during the initial 24 h after HAP diagnosis may be useful for the prediction of 30-day mortality in HAP patients in non-surgical departments.The qSOFA score may be a simple tool that can be used to quickly identify severe infections. | Jia-Ning Wen Nan Li Chen-Xia Guo Ning Shen Bei He | 2020 | Chinese Medical Journal2020，，24： | 7 |
| 4 | Tissue microarrays in pathological examination of apoptotic acinar cells induced by dexamethasone in the pancreas of rats with severe acute pancreatitis显示文摘BACKGROUND:The good therapeutic effects of large dose of dexamethasone on severe acute pancreatitis(SAP) patients have been proved.This study was designed to investigate the influence of dexamethasone on apoptosis of acinar cells in the pancreas of rats with SAP and the protein expression of the apoptosis-regulating genes Bax and Bcl-2. METHODS:Ninety Sprague-Dawley rats with SAP were randomly divided into a model group and a dexamethasone treated group(45 rats in each group),and another 45 rats formed the sham operation group.Survival rates were calculated and gross pathological changes in the pancreas of each group were observed under a light microscope 3,6 and 12 hours after operation.Tissue microarray technology was applied to prepare pancreatic tissue sections.The changes in Bax and Bcl-2 protein expression levels of pancreatic tissues from each group were assessed by immunohistochemical staining,and TUNEL staining was used to evaluate changes in apoptosis index. RESULTS:The model and treated groups did not differ in mortality at each time point.The pathological score for the pancreas in the treated group was significantly lower than that in the model group at 3 and 6 hours.The positive rates of Bax protein expression in the head and tail of the pancreas in the treated group at all time points were all markedly higher than those of the model group. The positive rate of Bcl-2 protein expression in the head of the pancreas in the treated group was significantly higher than that of the model group at 3 hours.TUNEL staining showed that the pancreas head and tail apoptosis indices of the treated group were markedly higher than those of the model group after 6 hours. CONCLUSIONS:Apoptosis may be a protective response to pancreatic cell injury.The mechanism of action of dexamethasone in treating SAP may be related to the apoptosis of acinar cells in the pancreas induced by apoptosis-regulating genes such as Bax and Bcl-2. The advantages of tissue microarrays in pathological examination of the pancreas include saving of time and energy,efficiency and highly representative. | Zhang, Xi-Ping Tian, Hua Lu, Bei Chen, Li Xu, Ru-Jun Wang, Ke-Yi Wang, Zhi-Wei Cheng, Qi-Hui Shen, Hai-Ping | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，5： | 7 |
| 5 | Easily manageable prognostic factors in 152 Chinese elderly acute myeloid leukemia patients:a single-center retrospective study显示文摘We retrospectively investigated the prognostic factors of acute myeloid leukemia(AML) in 152 Chinese patients with de novo AML who were older than 60 years of age and who received treatment at our hospital.Log-rank test showed that 6 parameters including older age,higher white blood cell(WBC) counts,lactate dehydrogenase(LDH)and bone marrow(BM) blasts at diagnosis,unfavorable risk cytogenetics,and non-mutated CEBPα were significant adverse prognostic factors of overall survival(OS) for elderly AML patients(P = 0.0013,0.0358,0.0132,0.0242,0.0236 and 0.0130,respectively).Moreover,older age and higher LDH were significant adverse predictors for relapse-free survival(RFS)(P = 0.0447 and 0.0470,respectively).Univariate analysis revealed similar results for OS to those of the log-rank test and only higher LDH at diagnosis was a significant adverse predictor for RFS(P = 0.028,HR:1.979,95%CI:1.075-3.644).In multivariate analysis,we identified 2 trends towards independent prognostic factors for OS,including BM blasts at diagnosis(P = 0.057,HR:1.676,95%CI:0.984-2.854)and mutation status of CEBPα(P = 0.064,HR:4.173,95%CI:0.918-18.966).Our data indicated that older age,gender and a previous history of hematologic diseases resulted in lower complete remission rate(P = 0.012,0.051 and 0.086,respectively).We further developed an easy scoring system for predicting prognosis and response to induction therapy in older AML patients.Patients who had lower scores showed significantly longer OS and RFS(P = 0.0006 and 0.1001,respectively) and higher CR rate(P = 0.014).Our research is limited by its retrospective nature and the results from our study need to be further validated by prospective randomized clinical trials. | Jiadai Xu Tingmei Chen Yun Liu Huayuan Zhu Wei Wu WenYi Shen Bei Xu Sixuan Qian Jianyong Li Peng Liu | 2014 | The Journal of Biomedical Research2014，28，5： | 7 |
| 6 | Behavior Measurement Model Based on Prediction and Control of Trusted Network显示文摘In order to construct the trusted network and realize the trust of network behavior,a new multi-dimensional behavior measurement model based on prediction and control is presented.By using behavior predictive equation,individual similarity function,group similarity function,direct trust assessment function,and generalized predictive control,this model can guarantee the trust of an end user and users in its network.Compared with traditional measurement model,the model considers different characteristics of various networks.The trusted measurement policies established according to different network environments have better adaptability.By constructing trusted group,the threats to trusted group will be reduced greatly.Utilizing trusted group to restrict individuals in network can ensure the fault tolerance of trustworthiness of trusted individuals and group.The simulation shows that this scheme can support behavior measurement more efficiently than traditional ones and the model resists viruses and Trojans more efficiently than older ones. | Gong Bei Zhang Jianbiao Shen Changxiang Zhang Xing | 2012 | China Communications2012，9，5： | 5 |
| 7 | Auto-mobilized adult hematopoietic stem cells advance neovasculature in diabetic retinopathy of mice显示文摘背景造血的干细胞(HSC ) 能被用来由指向活跃星形细胞把机能上地活跃的 angiostatic 分子送到网膜的 vasculature 并且可能在指向 pre-angiogenic 有用网膜的损害。我们寻求了决定 HSC 动员是否能改善在 mice.Methods 老鼠的早糖尿病的 retinopathy 是进四个组的 devided:正常老鼠控制组,动员 HSC 的组,糖尿病的老鼠控制组和糖尿病的老鼠 HSC 动员了的正常老鼠组织。鼠科的干细胞生长因素(鼠科的 SCF ) 和重新结合的人的 granulocyte 殖民地刺激因素(rhG-csf ) 与糖尿病并且没有糖尿病予鼠标被以为连续导致自体同源的 HSC 动员的 5 天,和下的注射生理盐被用作控制。Immunohistochemical 两倍染色与反老鼠老鼠 CD31 monoclonal 抗体被进行, anti-BrdU 老鼠 antibody.Results 标记清楚地在 SCF 正 G-csf-mobilization 以后增加的 HSC。老鼠比正常老鼠(P=0.032 ) 看了更多的 HSC 的非动员的糖尿病患者,和外部血显著地在糖尿病患者和老鼠显示出的正常老鼠(P=0.000 ).Diabetic 增加了更多的 CD31 积极毛状的容器(P=0.000 ) 和加速的 endothelial 房间新生。仅仅糖尿病的动员 HSC 的老鼠在动员汽车的成年造血的干细胞在老鼠的糖尿病的 retinopathy 预付 neovasculature 的新 capillaries.Conclusion 的 endothelial 房间表示了 BrdU 和 CD31 抗原。 | TIAN Bei LI Xiao-xin SHEN Li ZHAO Min YU Wen-zhen | 2010 | Chinese Medical Journal2010，，16： | 4 |
| 8 | Simultaneous Determination of Bisphenols and Alkylphenols in Water by Solid Phase Extraction and Ultra Performance Liquid Chromatography-tandem Mass Spectrometry显示文摘To establish an analytical method for determination of four bisphenols(BPA,BPB,BPF,and BPS)and two alkylphenols(4-n-OP,4-n-NP)in water by ultra performance liquid chromatographytandem mass spectrometry(UPLC/MS/MS).The water samples were extracted and condensed with solid-phase extraction(SPE)using C18 cartridges and eluted by acetonitrile.Separation was carried out with Acquity BEH C8 column and detection were performed by UPLC/MS/MS.Quantification | SHAN Xiao Mei SHEN Deng Hui WANG Bing Shuang LU Bei Bei HUANG Fa Yuan | 2014 | Biomedical and Environmental Sciences2014，27，6： | 4 |
| 9 | A Trusted Measurement Scheme Suitable for the Clients in the Trusted Network显示文摘The trusted network connection is a hot spot in trusted computing field and the trust measurement and access control technology are used to deal with network security threats in trusted network.But the trusted network connection lacks fine-grained states and real-time measurement support for the client and the authentication mechanism is difficult to apply in the trusted network connection,it is easy to cause the loss of identity privacy.In order to solve the abovedescribed problems,this paper presents a trust measurement scheme suitable for clients in the trusted network,the scheme integrates the following attributes such as authentication mechanism,state measurement,and real-time state measurement and so on,and based on the authentication mechanism and the initial state measurement,the scheme uses the realtime state measurement as the core method to complete the trust measurement for the client.This scheme presented in this paper supports both static and dynamic measurements.Overall,the characteristics of this scheme such as fine granularity,dynamic,real-time state measurement make it possible to make more fine-grained security policy and therefore it overcomes inadequacies existing in the current trusted network connection. | GONG Bei ZHANG Jianbiao YE Xiaolie SHEN Changxiang | 2014 | China Communications2014，11，4： | 3 |
| 10 | Long-term variations of X-ray pulse profiles for the Crab pulsar:data analysis and modeling显示文摘The pulse profiles of the Crab pulsar(as well as some other pulsars)vary with time.They can lead to a major source of intrinsic timing noise,which lacks a detailed physical model.The phase separation?between the first left peak(P1)and the second right peak(P2)is a key parameter that shows the variations of pulse profiles for the Crab pulsar.It was found that the evolution of?has a tendency with increasing rates of 0.82?±0.25?,0.80?±0.54?,and 0.77?±0.28?per century for the 2-6,6-15,and15-60 ke V bands,respectively.Furthermore,the flux ratios(P2/P1)of X-ray pulse profiles in the three bands were calculated,and the derived flux ratios were consistent with the radio and X-ray measurements of the Insight-HXMT.In addition to discovering the physical origin of the pulse changes,the high-SNR X-ray pulse profiles were simulated in the annular gap model,and two model parameters(e.g.,the maximum emission heights of the two peaks)were observed to slightly affect the variations of peak separation.We fitted the long-term variations of emission heights of the two peaks and discovered that the emission heights showed increasing tendencies with time.Variations of these emission heights induced a characteristic period derivative,and a complete formula for both the magnetic dipole radiation and wind-particle-induced variations of the moment of inertia was used for the pulsar’s spin-down to obtain the variation rate˙αof the magnetic inclination angle,which was-1.60?per century.Intrinsic timing noise is observed to be mainly induced by the variations of pulse profiles,which might correlate with a characteristic spin period derivative arising from the fluctuations of the emission regions.This work will lay a foundation for understanding the origin of intrinsic timing noise and making high-precision timing models in the future. | LunHua Shang YuanJie Du XiangQun Cui ShiJun Dang JiGuang Lu JunTao Bai QiJun Zhi YouLi Tuo LinLi Yan LiangWei Huang XinYuan Zhang XiaoMin Bei QingQing Lin GuoJun Qiao Hua Shen RiHong Zhu | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，10： | 2 |
| 11 | Poly(L-lactide)-Poly(ethylene glycol) Multiblock Copolymers: Synthesis and Properties显示文摘Poly (L-lactide)-poly(ethylene glycol) multiblock copolymers with predetermined block lengths were synthesized by polycondensation of PLA diols and PEG diacids. These copolymers presented special properties, such as better miscibility between the two components, low crystallinity and better hydrophilicity, which can be modulated by adjusting the block lengths of the two components. | Wei Jun LUO, Su Ming LI, Jian Zhong BEI, Shen Guo WANG* Center fpr Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080 | 2002 | Chinese Chemical Letters2002，13，1： | 2 |
| 12 | ACE2-independent infection of T lymphocytes by SARS-CoV-2显示文摘SARS-CoV-2 induced marked lymphopenia in severe patients with COVID-19.However,whether lymphocytes are targets of viral infection is yet to be determined,although SARS-CoV-2 RNA or antigen has been identified in T cells from patients.Here,we confirmed that SARS-CoV-2 viral antigen could be detected in patient peripheral blood cells(PBCs)or postmortem lung T cells,and the infectious virus could also be detected from viral antigen-positive PBCs.We next prove that SARS-CoV-2 infects T lymphocytes,preferably activated CD4+T cells in vitro.Upon infection,viral RNA,subgenomic RNA,viral protein or viral particle can be detected in the T cells.Furthermore,we show that the infection is spike-ACE2/TMPRSS2-independent through using ACE2 knockdown or receptor blocking experiments.Next,we demonstrate that viral antigen-positive T cells from patient undergone pronounced apoptosis.In vitro infection of T cells induced cell death that is likely in mitochondria ROS-HIF-1a-dependent pathways.Finally,we demonstrated that LFA-1,the protein exclusively expresses in multiple leukocytes,is more likely the entry molecule that mediated SARS-CoV-2 infection in T cells,compared to a list of other known receptors.Collectively,this work confirmed a SARS-CoV-2 infection of T cells,in a spike-ACE2-independent manner,which shed novel insights into the underlying mechanisms of SARS-CoV2-induced lymphopenia in COVID-19 patients. | Xu-Rui Shen Rong Geng Qian Li Ying Chen Shu-Fen Li Qi Wang Juan Min Yong Yang Bei Li Ren-Di Jiang Xi Wang Xiao-Shuang Zheng Yan Zhu Jing-Kun Jia Xing-Lou Yang Mei-Qin Liu Qian-Chun Gong Yu-Lan Zhang Zhen-Qiong Guan Hui-Ling Li Zhen-Hua Zheng Zheng-Li Shi Hui-Lan Zhang Ke Peng Peng Zhou | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 13 | Animal exercise studies in cardiovascular research:Current knowledge and optimal design--A position paper of the Committee on Cardiac Rehabilitation,Chinese Medical Doctors’Association显示文摘Growing evidence has demonstrated exercise as an effective way to promote cardiovascular health and protect against cardiovascular diseases However,the underlying mechanisms of the beneficial effects of exercise have yet to be elucidated.Animal exercise studies are widely used to investigate the key mechanisms of exercise-induced cardiovascular protection.However,standardized procedures and well-established evaluation indicators for animal exercise models are needed to guide researchers in carrying out effective,high-quality animal studies using exercise to prevent and treat cardiovascular diseases.In our review,we present the commonly used animal exercise models in cardiovascular research and propose a set of standard procedures for exercise training,emphasizing the appropriate measurements and analysis in these chronic exercise models.We also provide recommendations for optimal design of animal exercise studies in cardiovascular research,including the choice of exercise models,control of exercise protocols,exercise at different stages of disease,and other considerations,such as age,sex,and genetic background.We hope that this position paper will promote basic research on exercise-induced cardiovascular protection and pave the way for successful translation of exercise studies from bench to bedside in the prevention and treatment of cardiovascular diseases. | Yihua Bei Lei Wang Rongjing Ding Lin Che Zhiqing Fan Wei Gao Qi Liang Shenghui Lin Suixin Liu Xiao Lu Yuqin Shen Guifu Wu Jian Yang Guolin Zhang Wei Zhao Lan Guo Junjie Xiao | 2021 | Journal of Sport and Health Science2021，10，6： | 2 |
| 14 | Ambulatory blood pressure monitoring in chinese children with obstructive sleep apnea/hypopnea syndrome显示文摘 | Zhifei Xu Bei Li Kunling Shen | 2012 | Pediatr Pulmonol2012，，3： | 1 |
| 15 | Solvent polarity-induced photoluminescence enhancement (SPIPE): A method enables several-fold increase in quantum yield of silicon nanoparticles显示文摘Fluorescent silicon nanoparticles (SiNPs) bring exciting opportunities for long-awaited silicon-based optical application, while intrinsic indirect band gap of silicon severely limits photoluminescent quantum yield (PLQY) of SiNPs. To address this critical issue, we herein demonstrate a facile and general method, Le., solvent polarity-induced photoluminescence enhancement (SPIPE)1 yielding several-fold increase in quantum yield (QY) of SiNPs. Typically, different kinds of 4-substituented-1,8-naphthalic anhydride molecules, Le., 4-Br-1,8-naphthalic anhydride (BNA)1 4-triphenylamino-1,8-naphthalic anhydride (TPNA)1 and 4-dimethylamino-1,8-naphthalic anhydride (DMNA)1 are rationally designed and synthesized, which serve as surface ligands for the production of BNA-, TPNA-, and DMNA-capped small-sized (diameter:- 3.8-5.8 nm) SiNPs with QY of^8%,~15%,~16%, respectively. Of particular significance, QY of the resultant SiNPs could be greatly enhanced from^10% to^50% through the SPlPE strategy. Taken together with the theoretical calculation and the results of time-correlated single photon counting, we reveal that actived excited-state charge transfer interactions between surface-covered ligand and silicon oxide coating would be responsible for the observed QY enhancement. Moreover, other five kinds of solvents (i.e., methanol, isopropanol, dimethyl sulfoxide, N,N-dimethylformamide, and acetonitrile) are further employed for the SiNPs treatment, and similar improvement of QY values are observed, convincingly demonstrating the universal evidence of SPIPE of the SiNPs. | Xiao-Bin Shen Bin Song Bei Fang Xiao Yuan You-Yong Li Shun-Yi Wang Shun-Jun Ji Yao He | 2019 | Nano Research2019，12，2： | 1 |
| 16 | Efficient Semantic-based Content Search in P2P Network显示文摘 | Shen Heng tao Shu Yanfeng Yu Bei | 2004 | IEEE Transaction on Knowledge and Data Engineering2004，16，7： | 1 |
| 17 | Efficient semantic-based content search in P2P network显示文摘 | Shen Hengtao Shu Yanfeng Yu Bei | 2004 | IEEE Transactions on Knowledge and Data Engineering2004，16，7： | 1 |
| 18 | A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis 显示文摘 | Lin Z Bei JX Shen M | 2011 | Nat Genet2011，44，： | 1 |
| 19 | Physiological and genetic properties of tomato fruits from 2 cultivars differing in chilling tolerance at cold storage显示文摘 | ZHAO Danying SHEN Lin FAN Bei | 2009 | J Food Sci2009，74，5： | 1 |
| 20 | Efficient Semantic-Based Content Search in P2P Network 显示文摘 | Heng Tao Shen Yanfeng Shu Bei Yu | 2004 | IEEE Transactions on Knowledge and Data Engineering2004，16，7： | 1 |
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