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| 1 | Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice显示文摘Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress(PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead(Pb) on skeletal health is well documented. As stress and Pb act on common biological targets via glucocorticoid signaling pathways and co-occur in the environment, this study first sought to assess the combined effect of stress and Pb on bone quality in association with alterations in glucocorticoid signaling. Bone parameters were evaluated using microCT, histomorphometry, and strength determination in 8-month-old male mouse offspring subjected to PS on gestational days 16 and 17, lifetime Pb exposure(100 p.p.m. Pb in drinking water), or to both. Pb reduced trabecular bone mass and, when combined with PS, Pb unmasked an exaggerated decrement in bone mass and tensile strength. Next, to characterize a mechanism of glucocorticoid effect on bone, prednisolone was implanted subcutaneously(controlled-release pellet, 5 mg·kg^(-1) per day) in 5-month-old mice that decreased osteoblastic activity and increased sclerostin and leptin levels. Furthermore, the synthetic glucocorticoid dexamethasone alters the anabolic Wnt signaling pathway. The Wnt pathway inhibitor sclerostin has several glucocorticoid response elements, and dexamethasone administration to osteoblastic cells induces sclerostin expression. Dexamethasone treatment of isolated bone marrow cells decreased bone nodule formation, whereas removal of sclerostin protected against this decrement in mineralization.Collectively, these findings suggest that bone loss associated with steroid-induced osteoporosis is a consequence of sclerostin-mediated restriction of Wnt signaling, which may mechanistically facilitate glucocorticoid toxicity in bone. | Eric E Beier Tzong-Jen Sheu Emily A Resseguie Masahiko Takahata Hani A Awad Deborah A Cory-Slechta J Edward Puzas | 2017 | Bone Research2017，5，2： | 3 |
| 2 | Sputum matrix metalloproteinase - 9, tiss inhibitor of metalloproteinase - 1, and their molar ratio in patients with chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and healthy subjects 显示文摘 | Beeh KM Beier J Kornmanno O | 2003 | Respir Med2003，97，： | 1 |
| 3 | p38 MAPK signaling during routine preimplantation development 显示文摘 | Natale D R Paliga A J Beier F | 2004 | Dev Biol2004，268，1： | 1 |
| 4 | Parental-specific methylat- ion of an imprinted transgene is established during gametogenesis and progressively changes during embryogenesis 显示文摘 | Chaillet J R Vogt T F Beier D R | 1991 | Cell1991，66，1： | 1 |
| 5 | Heavy Metal Lead Exposure, Osteoporotie-like Phenotype in an Animal Model, and Depression of Wnt Signaling显示文摘 | Beier E E Maher J Sheu T J | 2013 | Environ Health Perspeet2013，121，1： | 1 |
| 6 | Advances in alcoholic liver disease显示文摘 | Beier J I Arteel G E McClain C J | 2011 | Curt Gastroenterol Rep2011，13，1： | 1 |
| 7 | Generation of a recombinant oncolytic Newcastle disease virus and expression of a full IgG antibody from two transgenes显示文摘 | Puhler F Willuda J Puhlmann J Mumberg D Romer-Oberdorfer A Beier R | 2008 | Gene Ther2008，15，5： | 1 |
| 8 | Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gels显示文摘 | Blum H Beier H Gross H J | | Electro- phoresis0，8，2： | 1 |
| 9 | Sputum matrix metallop rotei2 nase -9 ,tissue inhibitor ofmetallop roteinase - 1 and their- molar ra2 tio in patientswith chronic obstructive pulmenary dis- ease,idiopathic pulmonary fibrosis and healthy subjects显示文摘 | Beeh KM Beier J Kommann O et ' tl | 2003 | Resp irMed2003，97，6： | 1 |
| 10 | Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gels 显示文摘 | Blum H Beiers H Gross H J | 1987 | Electrophoresis1987，8，2： | 1 |
| 11 | New interdigital design for large area dye solar modules using a lead-free glass frit sealing显示文摘 | Sastrawan R Beier J Belledin U | 2006 | Progress in Photovoltaics: Research and Applications2006，14，8： | 1 |
| 12 | Pyrolysis ofsome gaseous and liquid hydrocarbons in hydrogen plasma 显示文摘 | Beiers H G Baumann H Bittner D Klein J Jüntgen H | 1988 | Fuel1988，67，7： | 1 |
| 13 | CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma显示文摘 | Coiffier B Lepage E Beiere J | 2002 | N Engl J Med2002，346，： | 1 |
| 14 | Sexual function and testicular perfusion after inguinal hernia repair with mesh显示文摘 | Zieren J Beyersdorff D Beier KM | 2001 | Am J Surg2001，181，3： | 1 |
| 15 | Kinetic investigations of layer formation by inhibitors with Cu/AHT as example 显示文摘 | Beier M Sthutze J W | 1992 | Electrochimica Acta1992，37，12： | 1 |
| 16 | An XML-based meta-language for dynamical generation of clinical documents within hospital information systems显示文摘 | Beier J Golze U Stach T | 2000 | International Congress Series2000，12，30： | 1 |
| 17 | Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gels显示文摘 | Blum H Beier H Hans J | 1987 | Electrophoresis1987，17，8： | 1 |
| 18 | Safety and efficacy of dual ther- apy with GSK233705 and salmeterol versus monotherapy with salmet- erol ,tiotropium, or placebo in a crossover pilot study in partially re- versible COPD patients显示文摘 | Beier J Van Noord J Deans A | 2012 | Int J Chmn Obstruct Pulmon Dis2012，7，： | 1 |
| 19 | Rhabdoid tumors in children: prognostic factors in 70 patients diagnosed in Germany 显示文摘 | Reinhard H Reinert J Beier R | 2008 | Oncol Rep2008，19，： | 1 |
| 20 | Aerobic epoxidation of olefins catalyzed by the cobalt-based metal-organic Framework STA-12(Co)显示文摘 | BEIER M J KLEIST W WHARMBY M T | 2012 | Chemistry-A European Journal2012，18，3： | 1 |
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