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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Early prediction of endocrine therapy effect in advanced breast cancer patients using ^99mTc-depreotide scintigraphy 显示文摘 | VAN DEN BOSSCHE B VAN BELLE S DE WINTER F | 2006 | J Nucl Med2006，47，11： | 1 |
| 3 | Prostaglandin ( F and E, 2-and 3-series) production and cy- clooxygenase (COX-2) gene expression of wild and cultured broodstock of Senegalese sole (Solea senegalensis) 显示文摘 | NORAMBUENA F MACKENZIE S BELL J G | 2012 | General and Comparative Endocrinology2012，177，2： | 1 |
| 4 | Diuretics:1,2,4-Benzothiadiazine-1,1-Dioxides显示文摘 | NoveUo F C Bell S C Abram s E L A | 1960 | J Org Chem1960，25，6： | 1 |
| 5 | Free metal activity and total metal concentrations as indices of micronutrient availability to barley (Hordeum rulgure(L) 'Klages')显示文摘 | Bell P F Chaney R L Angle J S | 1991 | Plant and Soil1991，130，： | 1 |
| 6 | Development and application of molecular marker linkage maps in woody fruit crops显示文摘 | N F Weeden M Hemmatt D M Lawson M Lodhi R L Bell A G Manganaris B I Reischs S K Brown G N Ye | 1994 | Euphytica1994，77，12： | 1 |
| 7 | Free metal activity and total metal concentrations as indices of micronutrient availability to barley显示文摘 | BELL P F CHANEY R L ANGLE J S | 1991 | Plant and soil1991，130，： | 1 |
| 8 | Environmental impacts associated with an abandoned mine in the Witbank Coalfield,South Africa显示文摘 | Bell F G Bullock S E T Halbich T F J | 2001 | International Journal of Coal Geology2001，45，2： | 1 |
| 9 | Boron deficiency in soybean, peanut and black gram: Symptoms in seeds and differences among soybean cultivars in susceptibility to boron deficiency显示文摘 | BELL R W LORDKAEW S LONERAGAN J F | 1993 | Plant and Soil1993，150，： | 1 |
| 10 | Dynamic aspects of velopharyngeal closure显示文摘 | Niimi S Bell - Berti F Harris KS | 1982 | Folia Phoniat1982，34，： | 1 |
| 11 | Mars Exploration Rover Athena Panoramic Camera (Pancam)investigation显示文摘 | Bell Ⅲ J F Squyres1 S W Herkenhoff K E | | 0，，12： | 1 |
| 12 | Natural copepods are superior to enriched Artemis nauplii as feed for halibut larvae (Hippoglossus hippoglossus) in terms of survival,pigmentation and retinal morphology:relation to dietary essential fatty acids显示文摘 | Shields R J Bell J G Luizi F S | 1999 | J Nutr1999，129，： | 1 |
| 13 | A randomised crossover trial comparing a single-use polyvinyl chloride laryngeal mask airway with a single-use silicone laryngeal mask airway显示文摘 | Bell S F Morris N G Rao A | 2012 | Anaesthesia2012，67，12： | 1 |
| 14 | Blue jets produced by quasi-electrostatic pre-discharge thundercloud fields显示文摘 | Pasko V P lnan U S Bell T F | 1996 | Geophysical Research Letters1996，23，： | 1 |
| 15 | The extracellular release of HMGB1 during apoptotie cell death显示文摘 | Bell C W Jiang W Reich C F 3 rd Pisetsky D S | 2006 | Am J Physiol Cell Physiol2006，291，： | 1 |
| 16 | Effects of forest floor disturbances by mechanical site preparation on floristic diversity in a central Ontario clearcut显示文摘 | Newmaster S G Parker W C Bell F W | 2007 | Forest Ecology and Management2007，246，： | 1 |
| 17 | Spatial structure of Sprites显示文摘 | Pasko V P Inan U S Bell T F | 1998 | Geophysical Research Letters1998，25，： | 1 |
| 18 | Large scale modeling of Sprites and blue jets 显示文摘 | Pasko V P Inan U S Bell T F | 1999 | EOS Transactions American Geophysical Union1999，，211： | 1 |
| 19 | Qualitative and quantitative evaluation of deconvolution for ion mobility spectrometry 显示文摘 | Bell S E Wang Y F Walsh M K | 1995 | Analytica Chimica Acta1995，303，： | 1 |
| 20 | A sequential zero valent iron and aerobic biodegradation treatment system for nitrobenzene显示文摘 | BELL L S DEVLIN J F GILLHAM R W | 2003 | Journal of Contaminant Hydrology2003，66，34： | 1 |
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