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| 1 | Antioxidant Machinery Related to Decreased MDA Generation by Thymus Algeriensis Essential Oil-induced Liver and Kidney Regeneration显示文摘Objective This study was conducted to determine the histopathological and biochemical effects of Thymus algeriensis essential oil(TEO) on hydrogen peroxide(H_2O_2)-induced oxidative stress in liver and kidney tissues of rats. Methods Rats were treated in six groups and were exposed for 2 weeks to low(LD; 100 μmol/L) and high doses(HD;1 mmol/L) of H_2O_2 in the presence or absence of TEO(180 mg/kg). Liver and kidney atrophy was measured by using biochemical and histopathological assays. Results Our study demonstrated that H_2O_2 induced liver and kidney atrophy, as evidenced by the significant elevation of serum aminotransferase, urea, and creatinine levels compared with those in the control rats. Urea levels were estimated by evaluating the activity of serum urease that hydrolyzes urea into CO_2 and ammonia. However, TEO treatment significantly alleviated oxidative stress in the H_2O_2-induced liver and kidney toxicity model by reducing the levels of malondialdehyde concomitantly with marked elevations in superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase, as well as decrease in glutathione activity. Conclusion Our data demonstrated that TEO protected against H_2O_2 toxicity by decreasing oxidant levels and DNA damage, as well as increasing antioxidant levels, indicating that TEO has a spectrum of antioxidant and DNA-protective properties. | Guesmi Fatma Amit K Tyagi Bellamine Houda Landoulsi Ahmed | 2016 | Biomedical and Environmental Sciences2016，29，9： | 3 |
| 2 | Function variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associ- ated with essential hypertension 显示文摘 | Gainer JV Bellamine A Dawson EP | 2005 | Circulation2005，111，1： | 1 |
| 3 | Confirmation of the role of auxin and calcium in the late phases of adventitious root formation显示文摘 | Bellamine J Penel C Greppin H | 1998 | Plant Growth Regulation1998，26，3： | 1 |
| 4 | Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3 ( 2 ) cytochrome P450 158A2 显示文摘 | Zhao B Guengerich F P Bellamine A | 2005 | J Biol Chem2005，280，11： | 1 |
| 5 | Confirmation of the role of auxin and calcium in the late phases of adventitious root formation显示文摘 | Penel C Greppin H | 1998 | Plant Growth Regul1998，26，3： | 1 |
| 6 | Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension显示文摘 | Gainer JV Bellamine A Dawson EP | 2005 | Circulation2005，111，： | 1 |
| 7 | Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension显示文摘 | Gainer JV Bellamine A Dawson EP | 2005 | Circulation2005，111，： | 1 |
| 8 | Structural requirements for substrate recognition of Mycobacterium tuberculosis 14a-demethylase: implications for sterol biosynthesis显示文摘 | Bellamine A Mangla AT Dennis AL | 2001 | Journal of Lipid Research2001，42，1： | 1 |
| 9 | Folding requirements are different between sterol 14α-demethylase (CYP51) from Mycobacterium tuberculosis and human or fungal orthologs显示文摘 | Lepesheva GI Podust LM Bellamine A | 2001 | Journal of Biological Chemistry2001，276，28： | 1 |
| 10 | Fluconazole binding and sterol demethylation in three CYP51 isoforms indicate differences in active site topology 显示文摘 | Bellamine A Lepesheva GI Waterman MR | 2004 | J Lipid Res2004，45，11： | 1 |
| 11 | Design of a Remote Diagnosis System for Rotating Machinery using Virtual Reality and Fuzzy Pattern Matching 显示文摘 | Bellamine M Abe N Tanaka K | 2003 | Proceedings of the 2003 IEEE/ASME International Conference on Advanced Intelligent Mechatronics (AIM2003)2003，，1： | 1 |
| 12 | Proton pump and IAA sensitivity changes in spinach leaves during the flowing induction显示文摘 | Bellamine J Penel C Greppin H | | 0，，02： | 1 |
| 13 | Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension 显示文摘 | Gainer JV Bellamine A Dawson EP | 2005 | Circulation2005，111，1： | 1 |
| 14 | Characterization and catalytic properties of the sterol 14alpha- demethylase from mycobacterium tuberculosis显示文摘 | BELLAMINE A MANGLA A T NES W D | 1999 | Proc Natl Acad Sci USA1999，96，16： | 1 |
| 15 | Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension显示文摘 | Gainer JV Bellamine A Dawson EP | 2005 | Circulation2005，111，1： | 1 |
| 16 | Functional va- riant of CYP4All 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension 显示文摘 | Gainer JV Bellamine A Dawson EP | 2005 | Circulation2005，111，： | 1 |
| 17 | Class I malocclusion with severe bimaxillary protrusion:a successful result显示文摘 | Bellamine M Bentahar Z El Quars F | 2013 | Odontostomatol Trop2013，36，144： | 1 |
| 18 | Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associ- ated with essential hypertension 显示文摘 | Gainer JV Bellamine A Dawson EP | 2005 | Circulation2005，111，1： | 1 |
| 19 | Characterization ofthe CYP4A11 gene,a second CYP4A gene in humans显示文摘 | Bellamine A Wang Y Waterman MR | 2003 | ArchBiochem Biophys2003，409，： | 1 |
| 20 | Coupling Agent Based Simulation with Dynamic Networks Analysis to Study the Emergence of Mutual Knowledge as a Percolation Phenomenon显示文摘The emergence of mutual knowledge is a major cognitive mechanism for the robustness of complex socio-technical systems. It has been extensively studied from an ethnomethodological point of view and empirically reproduced by multi-agent simulations. Whilst such simulations have been used to design real work settings the underlying theoretical grounding for the process is vague. The aim of this paper is to investigate whether the emergence of mutual knowledge(MK) in a group of colocated individuals can be explained as a percolation phenomenon. The followed methodology consists in coupling agent-based simulation with dynamic networks analysis to study information propagation phenomena: After using an agent-based simulation the authors generated and then analyzed its traces as networks where agents met and exchanged knowledge. Deep analysis of the resulting networks clearly shows that the emergence of MK is comparable to a percolation process. The authors specifically focus on how changes at the microscopic level in the proposed agent based simulator affect percolation and robustness. These results therefore provide theoretical basis for the analysis of social organizations. | DUGDALE Julie BELLAMINE BEN SAOUD Narjes ZOUAI Fedia PAVARD Bernard | 2016 | Journal of Systems Science & Complexity2016，29，5： | 1 |
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