|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Methionine adenosyltransferases in liver cancer显示文摘Methionine adenosyltransferases(MATs)are essential enzymes for life as they produce S-adenosylmethionine(SAMe),the biological methyl donor required for a plethora of reactions within the cell.Mammalian systems express two genes,MAT1A and MAT2A,which encode for MATα1 and MATα2,the catalytic subunits of the MAT isoenzymes,respectively.A third gene MAT2B,encodes a regulatory subunit known as MATβwhich controls the activity of MATα2.MAT1A,which is mainly expressed in hepatocytes,maintains the differentiated state of these cells,whilst MAT2A and MAT2B are expressed in extrahepatic tissues as well as non-parenchymal cells of the liver(e.g.,hepatic stellate and Kupffer cells).The biosynthesis of SAMe is impaired in patients with chronic liver disease and liver cancer due to decreased expression and inactivation of MATα1.A switch from MAT1A to MAT2A/MAT2B occurs in multiple liver diseases and during liver growth and dedifferentiation,but this change in the expression pattern of MATs results in reduced hepatic SAMe level.Decades of study have utilized the Mat1a-knockout(KO)mouse that spontaneously develops non-alcoholic steatohepatitis(NASH)and hepatocellular carcinoma(HCC)to elucidate a variety of mechanisms by which MAT proteins dysregulation contributes to liver carcinogenesis.An increasing volume of work indicates that MATs have SAMe-independent functions,distinct interactomes and multiple subcellular localizations.Here we aim to provide an overview of MAT biology including genes,isoenzymes and their regulation to provide the context for understanding consequences of their dysregulation.We will highlight recent breakthroughs in the field and underscore the importance of MAT’s in liver tumorigenesis as well as their potential as targets for cancer therapy. | Ben Murray Lucia Barbier-Torres Wei Fan JoséM Mato Shelly C Lu | 2019 | World Journal of Gastroenterology2019，25，31： | 10 |
| 2 | Audit pricing and nature of controlling shareholders:Evidence from France显示文摘This study examines whether auditors are employed as a monitoring mechanism to mitigate agency problems arising from different types of controlling shareholders. In a context of concentrated ownership and poor investor protection, controlling shareholders can easily expropriate wealth from minority shareholders and profit from private benefits of control. However, this agency conflict has been rarely studied, as the most commonly assumed agency conflict occurs between managers and shareholders. Using an audit fee model derived from Simunic(1980), we study the impact of the nature of controlling shareholders on audit fees in French listed firms. Our results show:(1) a negative relationship between audit fees and government shareholdings;(2) a positive relationship between audit fees and institutional shareholdings; and(3) no relationship between audit fees and family shareholdings. These results illustrate the mixed effects of the nature of ownership on audit fees. | Chiraz Ben Ali Cdric Lesage | 2013 | China Journal of Accounting Research2013，，1： | 3 |
| 3 | Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome: A Delphi technique-based consensus显示文摘AIM To propose several alternatives treatment of type 1 hepatorenal syndrome(HRS-1) what is the most severe expression of circulatory dysfunction on patients with portal hypertension.METHODS A group of eleven gastroenterologists and nephrologists performed a structured analysis of available literature.Each expert was designated to review and answer a question.They generated draft statements for evaluation by all the experts.Additional input was obtained from medical community.In order to reach consensus,a modified three-round Delphi technique method was used.According to United States Preventive Services Task Force criteria,the quality of the evidence and level of recommendation supporting each statement was graded.RESULTS Nine questions were formulated.The available evidence was evaluated considering its quality,number of patients included in the studies and the consistency of its results.The generated questions were answered by the expert panel with a high level of agreement.Thus,a therapeutic algorithm was generated.The role of terlipressin and norepinephrine was confirmed as the pharmacologic treatment of choice.On the other hand the use of the combination of octreotide,midodrine and albumin without vasoconstrictors was discouraged.The role of several other options was also evaluated and the available evidence was explored and discussed.Liver transplantation is considered the definitive treatment for HRS-1.The present consensus is an important effort that intends to organize the available strategies based on the available evidence in the literature,the quality of the evidence and the benefits,adverse effects and availability of the therapeutic tools described.CONCLUSION Based on the available evidence the expert panel was able to discriminate the most appropriate therapeutic alternatives for the treatment of HRS-1. | Juan P Arab Juan C Claro Juan P Arancibia Jorge Contreras Fernando Gomez Cristian Munoz Leyla Nazal Eric Roessler Rodrigo Wolff Marco Arrese Carlos Benítez | 2016 | World Journal of Hepatology2016，8，25： | 3 |
| 4 | In Vitro Effects of Cyclosporine A and Tacrolimus on Regulatory T-Cell Proliferation and Function显示文摘 | Céline Miroux Olivier Morales Khaldoun Ghazal Samia Ben Othman Yvan de Launoit Véronique Pancré Filomena Conti Nadira Delhem | 2012 | Transplantation Journal2012，，2： | 2 |
| 5 | Effect of calcium-based versus non-calcium-based phosphate binders on mortality in patients with chronic kidney disease: an updated systematic review and meta-analysis显示文摘 | Sophie A Jamal Ben Vandermeer Paolo Raggi David C Mendelssohn Trish Chatterley Marlene Dorgan Charmaine E Lok David Fitchett Ross T Tsuyuki | 2013 | The Lancet2013，，： | 2 |
| 6 | Effect of dietary phospholipid levels on performance, enzyme activities and fatty acid composition of pikeperch (Sander lucioperca) larvae显示文摘 | Hamza M Mhetli I Ben K C | 2008 | Aquaculture2008，275，： | 1 |
| 7 | A large-scale Web-based virtual oscilloscope laboratory experiment显示文摘 | Ben C C Ko Chen M | 2000 | Engineering Science and Education Joumal2000，，4： | 1 |
| 8 | Expandable liner hanger provides cost-effective alternative solution显示文摘 | LEE LOHOEFER C MATHIS BEN DAVID BRISCO | | SPE0，2000，： | 1 |
| 9 | (A) 显示文摘 | Cao Huai xin Xu zong ben Zhang Jian hua Matrix-trace on C^*- algebra M | 2002 | Linear Algebra and its Applications2002，，345： | 1 |
| 10 | Bioactive nanocrystalline sol-gel hydroxyapatite coatings显示文摘 | CHAI C S BEN NISSAN B | 1999 | Journal of Materials Science: Materi als in Medicine1999，10，8： | 1 |
| 11 | Increased antifungal activity of Tfichoderma harzianum transformants that overexpress a 33-kDa chitinase显示文摘 | Limon M C Pintor-Toro J A Benítez T | 1999 | Phytopathol1999，89，： | 1 |
| 12 | High-efficiency LED backlight optics designed with the flow-line method显示文摘 | MINANO J C BEN(I)TEZ P CHAVES J | | 0，，： | 1 |
| 13 | Recent Humanto-Poultry Host Jump,Adaptation,and Pandemic Spread of Staphylococcus Aureus显示文摘 | LOWDER B V GUINANE C M BEN ZAKOUR NL | 2009 | Proc Natl Acad Sci U S A2009，106，19： | 1 |
| 14 | Isolation and identifica- tion of mycoparasitic isolates of Tdchoderma aspere/um with potential for suppression of black pod disease of cacao in Cameroon显示文摘 | Tondje P R Roberts D P Ben M C | 2007 | Bio- logical Control2007，43，2： | 1 |
| 15 | Secondary Forests as Tem- porary Carbon Sinks?The Economic Impact of Accounting Methods on Reforestation Projects in the Tropics显示文摘 | OLSCHEWSKI R BEN~TEZ P C | 2005 | Ecolog- ical Economics2005，55，3： | 1 |
| 16 | Communication between multiple drug binding sites on P - glycoprotein 显示文摘 | Martin C Ben'idge G Higgins CF | 2000 | Mol Pharmacol2000，58，3： | 1 |
| 17 | A model of transient unilateral focal ischemia with reperfusion in the P7 neonatal rat: morphological changes indicative of apoptosis显示文摘 | Renolleau S Aggoun Zouaoui D Ben Ari Y Charriaut-Marlan gue C | 1998 | Stroke1998，29，： | 1 |
| 18 | Sorption and desorption characteristics of a packed bed of clay-CaCl2 desiccant particles 显示文摘 | Tretiak C S Ben A N | 2009 | Solar Energy2009，83，10： | 1 |
| 19 | Distribution of substituents in carboxymethyl ethers of cyclomaltoheptaose 显示文摘 | Ben J R Rao C T Pitjha J1 | 1994 | Carbohydrate research1994，258，： | 1 |
| 20 | Polyphasic study of the spatial distribution of microorganisms in Mexican Pozol, a fer- mented maize dough, demonstrates the need for cultivation-inde- pendent methods to investigate traditional fermentations显示文摘 | Ampe F Ben Omar N Moizan C | 1999 | Ap- plied and Environmental Microbiology1999，，65： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员