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| 1 | Predictive factors of survival in patients treated with definitive chemoradiotherapy for squamous cell esophageal carcinoma显示文摘瞄准:学习的目的是与食道的癌(LASCOC ) 与权威的 chemoradiotherapy (CRT ) 对待的局部地先进的有鳞的房间在病人评估幸存的预兆的因素政体基于 5FU/CDDP 联合。方法:有用在 1994 和 2000 之间的 5FU/CDDP 联合与权威的 CRT 对待的 LASCOC 的所有病人回顾地被包括。对 CRT 的临床的完全的反应(CCR ) 被食道的内视镜检查法和 CT 扫描估计在 CRT 结束以后的 2 瞬间。幸存的预示的因素用 univariate 被估计,多,由艇长回归的变量分析当模特儿。结果:116 个病人的一个总数在学习被包括。到 CRT 的 CCR 在 86/116 (74.1%) 被观察。中部的幸存是 20 瞬间(范围 2-114 ) , 5 年的幸存是 9.4% 。到 CRT 的应答者病人的中部的幸存在非应答者病人作为与 9 瞬间(范围 2-81 ) 相比是 25 瞬间(范围 3-114 )(P <
0.001 ) 。在 univariate 分析,幸存与 CCR 被联系(P <
0.001 ) ,表演地位 <
2 (P = 0.01 ) ,瘤长度 <
6 厘米(P = 0.045 ) 并且 10% 在意义的限制的重量损失 <
(P = 0.053 ) 。在里面多变量分析,幸存对 CCR 依赖(P <
0.0001 ) ,重量损失 <
10%(P = 0.034 ) 并且表演 <
2 (P = 0.046 ) 。结论:我们的结果建议在有与权威的 CRT 对待的 LASCOC 的病人的那幸存被相关到 CCR,重量损失并且表演地位。 | Frédéric Di Fiore Stéphane Lecleire Olivier Rigal Marie-Pierre Galais Emmanuel Ben Soussan Isabelle David Bernard Paillot Jacques-Henri Jacob Pierre Michel | 2006 | World Journal of Gastroenterology2006，12，26： | 13 |
| 2 | Conducting health policy analysis in primary care research: turning clinical ideas into action显示文摘Healthcare guidelines play a prominent role in the daytoday practice of primary care providers,and health policy research leads to the formation of these guidelines.Health policy research is the multidisciplinary approach to public policy explaining the interaction between health institutions,special interests and theoretical constructs.In this article,we demonstrate how primary care providers can conduct high-impact health policy research using Eugene Bardach’s eightfold policy analysis framework in a primary care context.In a medical case,a woman with a history of total hysterectomy had scheduled a visit for a Papanicolaou(Pap)smear screening test as part of a well-woman health check-up with a family medicine resident.Conflicting recommendations on Pap smear screening after total hysterectomy sparked an investigation using the US Preventive Services Task Force criteria for conducting a health policy analysis.We illustrate broadly how clinical care dilemmas can be examined by using Bardach’s broadly applicable health policy framework in order to inform meaningful policy change.Bardach’s framework includes(1)defining the problem,(2)assembling evidence,(3)constructing alternatives,(4)selecting criteria,(5)projecting outcomes,(6)confronting trade-offs,(7)decision-making and(8)sharing the results of the process.The policy analysis demonstrated insufficient evidence to recommend Pap test screening after hysterectomy and the findings contributed to national recommendations.By following Bardach’s steps,primary care researchers have a feasible and powerful tool for conducting meaningful health policy research and analysis that can influence clinical practice. | Alina Engelman Ben Case Lisa Meeks Michael D Fetters | 2019 | Family Medicine and Community Health2019，7，2： | 6 |
| 3 | Comparative analysis of Solanum stoloniferum responses to probing by the green peach aphid Myzus persicae and the potato aphid Macrosiphum euphorbiae显示文摘抽象植物由种类特定的防卫机制保护自己免于蚜虫攻击。以前,我们证明了茄属 stoloniferum Schlechtd 有抵抗因素到 Myzus persicae Sulzer (Homoptera:Aphididae ) 在 epidermal/mesophyll 水平,那不对 Macrosiphum euphorbiae 托马斯是有效的(Homoptera:Aphididae ) 。这里,我们比较 nymph 的死亡, pre 繁殖的发展时间,和 M 的探查的行为。persicae 和 M。S 上的 euphorbiae。stoloniferum 和茄属 tuberosum L。而且,我们在 S 在基因表示分析变化。stoloniferum 96 个小时由也张贴群袭蚜虫种类。尽管 M。探查蚜虫遇到更多的探查的行为表演的 euphorbiae 在韧皮部 activitieslonger 在 S 上探查和分泌唾液时间上抑制。stoloniferum 比在 S 上。tuberosum,蚜虫成功了在两植物上到达韧皮部树液的持续摄取。由 M 探查。S 上的 persicae。stoloniferum 植物导致了仅仅的有限的喂。M 的幸存。euphorbiae 和 M。persicae 在年轻叶子,然而并非在 S 的衰老的叶子被影响。stoloniferum。由 M 的群袭。euphorbiae 比 M 改变了更多的基因的表示。persicae 做了。在全身的水平,两个蚜虫得到了弱回答。S 的群袭。有很多 M 的 stoloniferum 植物。persicae 在叶子导致了词法变化,导致被破坏脉管的实质引起并且包围织物的色点的发展。相反,由 M 的群袭。euphorbiae 没有词法效果。两个都,植物种类能为 M 被认为是好主人。euphorbiae,而仅仅 S。tuberosum 是为 M 的一位好主人。persicae 和 S。stoloniferum 不是。S 的群袭。由 M 的 stoloniferum。persicae 或 M。euphorbiae 象一套普通基因一样改变了为每蚜虫特定的一套植物基因的表示。 | Adriana E. Alvarez Viviana G. Broglia Anahi M. Alberti D'Amato Doret Wouters Edwin van der Vossen Elisa Garzo W. Fred Tjallingii Marcel Dicke Ben Vosman | 2013 | Insect Science2013，20，2： | 5 |
| 4 | Imaging of liver cancer显示文摘Improvements in imaging technology allow exploitation of the dual blood supply of the liver to aid in the identif ication and characterisation of both malignant and benign liver lesions. Imaging techniques available include contrast enhanced ultrasound, computed tomography and magnetic resonance imaging. This review discusses the application of several imaging techniques in the diagnosis and staging of both hepatocellular carcinoma and cholangiocarcinoma and outlines certain characteristics of benign liver lesions. The advantages of each imaging technique are highlighted, while underscoring the potential pitfalls and limitations of each imaging modality. | Ben Ariff Claire R Lloyd Sameer Khan Mohamed Shariff Andrew V Thillainayagam Devinder S Bansi Shahid A Khan Simon D Taylor-Robinson Adrian KP Lim | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 5 | Anti-inflammatory and analgesic activities with gastroprotective effect of semi-purified fractions and isolation of pure compounds from Mediterranean gorgonian Eunicella singularis显示文摘Objective: To explore anti-inflammatory activities of organic extract and its semi-purified fractions(ethanol, acetone, methanol/dichloromethane) from the Mediterranean gorgonian Eunicella singularis. Methods: The anti-inflammatory and analgesic activities were evaluated, using the carrageenan-induced rat paw edema model and the acetic acid writhing test in mice. The gastroprotective activity was determined using HCl/Et OH induced gastric ulcers in rats. The purification and structure elucidation of compound(s) from the more effective fraction were determined by chromatographic and spectroscopic methods and in comparison with data reported in the literature. Results: The fraction F-Et OH showed an important antiinflammatory activity associated with significant analgesic and gastroprotective properties. The purification and structure elucidation of compound(s) from this fraction lead to the identification of one diterpenoid and four sterols. Conclusions: These results suggested that components from the active fraction can be used to treat various anti-inflammatory diseases. | Monia Deghrigue Carmen Festa Lotfi Ghribi Maria Valeria D’Auria Simona De Marino Hichem Ben Jannet Abderrahman Bouraoui | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，8： | 2 |
| 6 | Intranigral iron injection induces behavioral and biochemical''parkinsonism''in rats显示文摘 | Ben shachar D Youdim MBH | 1991 | Neurochemistry1991，57，： | 2 |
| 7 | Phase Ⅱ trial of high-dose conformal radiation therapy with concurrent hepatic artery floxuridine for unresectable intrahepatic malignancies显示文摘 | Ben -Josef E Normolle D Ensminger WD | 2005 | J Clin Oncol2005，23，34： | 1 |
| 8 | Development of an ultramicroelectrode arrays(UMEAs) sensor for trace heavy metal measurement in water显示文摘 | Xie X D Stüben D Berner Z | 2004 | Sensors and Actuators B2004，97，23： | 1 |
| 9 | A comparative study of immunohistochemistry and electron microscopy used in the diagnosis of epidermolysis bullosa 显示文摘 | Petronius D Bergman R Ben Izhak O | 2003 | Am J Dermatopathol2003，25，3： | 1 |
| 10 | Heterologous expression,secretion and characterization of the Geobacillus thermoleovorans US105 type Ⅰ pullulanase显示文摘 | Zouari Ayadi D Ben Ali M Jemli S Ben Mabrouk S Mezghani M Ben Messaoud E Bejar S | | 0，，03： | 1 |
| 11 | Overestimation of moderate carotid stenosis assessed by both Doppler US and contrast enhanced 3D-MR angiography in the CARMEDAS study显示文摘 | Nonent M Ben Salem D Serfaty JM | | 0，，03： | 1 |
| 12 | Value of rou- tine bone scans in patients with bone sarcomas before local treatment显示文摘 | Bakri D Bar-Shalona R Ben Arush MW | 2011 | J Pediatr Hematol Oneol2011，33，2： | 1 |
| 13 | Heterologous expres- sion,secretion and characterization of the Geobaeillus thermoleo- vorans US105 type I pullulanase显示文摘 | Zouari Ayadi D Ben Ali M Jemli S | 2008 | Applied microbiology and biotechnology2008，78，： | 1 |
| 14 | Isolation and identifica- tion of mycoparasitic isolates of Tdchoderma aspere/um with potential for suppression of black pod disease of cacao in Cameroon显示文摘 | Tondje P R Roberts D P Ben M C | 2007 | Bio- logical Control2007，43，2： | 1 |
| 15 | A model of transient unilateral focal ischemia with reperfusion in the P7 neonatal rat: morphological changes indicative of apoptosis显示文摘 | Renolleau S Aggoun Zouaoui D Ben Ari Y Charriaut-Marlan gue C | 1998 | Stroke1998，29，： | 1 |
| 16 | Efficient immunization strategies for computer networks and populations 显示文摘 | COHEN R HAVLIN S BEN D A | 2003 | Physical Review Letters2003，91，24： | 1 |
| 17 | A comparative study of immunohistochemistry and electron microscopy used in the diagnosis of epidermolysis bullosa显示文摘 | Petronius D Bergman R Ben lzhak O | 2003 | Am J Dermatopathol2003，25，3： | 1 |
| 18 | The tumor suppressor maspin mediates E2F1-induced sensitivity of cancer cells to chemotherapy显示文摘 | BEN SHACHAR B FELDSTEIN O HACOHEN D | 2010 | Mol Cancer Res2010，8，3： | 1 |
| 19 | On the power of randomization in on-line algorithms显示文摘 | Ben D S Borodin A Karp R | 1994 | Algorithmic1994，11，1： | 1 |
| 20 | DNA topoisomerase IIstructures and anthracycline activity: insights into ternary com-plex formation显示文摘 | Dal Ben D Palumbo M Zagotto G | 2007 | Curr Pharm Des2007，13，27： | 1 |
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