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| 1 | Stem cell-derived exosomes-an emerging tool for myocardial regeneration显示文摘Cardiovascular diseases(CVDs) continue to represent the number one cause of death and disability in industrialized countries. The most severe form of CVD is acute myocardial infarction(AMI), a devastating disease associated with high mortality and disability. In a substantial proportion of patients who survive AMI, loss of functional cardiomyocytes as a result of ischaemic injury leads to ventricular failure, resulting in significant alteration to quality of life and increased mortality. Therefore, many attempts have been made in recent years to identify new tools for the regeneration of functional cardiomyocytes. Regenerative therapy currently represents the ultimate goal for restoring the function of damaged myocardium by stimulating the regeneration of the infarcted tissue or by providing cellsthat can generate new myocardial tissue to replace the damaged tissue. Stem cells(SCs) have been proposed as a viable therapy option in these cases. However, despite the great enthusiasm at the beginning of the SC era, justified by promising initial results, this therapy has failed to demonstrate a significant benefit in large clinical trials. One interesting finding of SC studies is that exosomes released by mesenchymal SCs(MSCs) are able to enhance the viability of cardiomyocytes after ischaemia/reperfusion injury, suggesting that the beneficial effects of MSCs in the recovery of functional myocardium could be related to their capacity to secrete exosomes. Ten years ago, it was discovered that exosomes have the unique property of transferring miRNA between cells, acting as miRNA nanocarriers. Therefore, exosomebased therapy has recently been proposed as an emerging tool for cardiac regeneration as an alternative to SC therapy in the post-infarction period. This review aims to discuss the emerging role of exosomes in developing innovative therapies for cardiac regeneration as well as their potential role as candidate biomarkers or for developing new diagnostic tools. | Erzsebet Lazar Theodora Benedek Szilamer Korodi Nora Rat Jocelyn Lo Imre Benedek | 2018 | World Journal of Stem Cells2018，10，8： | 12 |
| 2 | Intralesional steroid is beneficial in benign refractory esophageal strictures:A meta-analysis显示文摘AIM To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal strictures.METHODS A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the randomeffects method of Der Simonian and Laird. Heterogeneity of the studies was tested by Cochrane's Q and I^2 statistics. Risk of quality and bias was assessed by the Newcastle Ottawa Scale and JADAD assessment tools.RESULTS Eleven articles were identified suitable for analyses, involving 343 patients, 235 cases and 229 controls in total. Four studies used crossover design with 121 subjects enrolled. The periodic dilation index(PDI) was comparable in 4 studies, where the pooled result showed a significant improvement of PDI in the steroid group(MD:-1.12 dilation/month, 95% CI:-1.99 to -0.25 P = 0.012; I^2 = 74.4%). The total number of repeat dilations(TNRD) was comparable in 5 studies and showed a non-significant decrease(MD:-1.17, 95%CI:-0.24-0.05, P = 0.057; I^2 = 0), while the dysphagia score(DS) was comparable in 5 studies and did not improve(SMD: 0.35, 95%CI:-0.38, 1.08, P = 0.351; I^2 = 83.98%) after intralesional steroid injection.CONCLUSION Intralesional steroid injection increases the time between endoscopic dilations of benign refractory esophageal strictures. However, its potential role needs further research. | László Szapáry Benedek Tinusz Nelli Farkas Katalin Márta Lajos Szakó Agnes Meczker Roland Hágendorn Judit Bajor Aron Vincze Zoltan Gyongyi Alexandra Mikó Dezso Csupor Péter Hegyi Balint Eross | 2018 | World Journal of Gastroenterology2018，24，21： | 7 |
| 3 | Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease显示文摘AIM: To establish a mouse model of alcohol-driven hepatocellular carcinoma(HCC) that develops in livers with alcoholic liver disease(ALD).METHODS: Adult C57BL/6 male mice received multiple doses of chemical carcinogen diethyl nitrosamine(DEN) followed by 7 wk of 4% Lieber-De Carli diet. Serum alanine aminotransferase(ALT), alpha fetoprotein(AFP) and liver Cyp2e1 were assessed. Expression of F4/80, CD68 for macrophages and Ly6 G, MPO, E-selectin for neutrophils was measured. Macrophage polarization was determined by IL-1β/i NOS(M1) and Arg-1/IL-10/CD163/CD206(M2) expression. Liver steatosis and fibrosis were measured by oil-red-O and Sirius red staining respectively. HCC development was monitored by magnetic resonance imaging, confirmed by histology. Cellular proliferation was assessed by proliferating cell nuclear antigen(PCNA).RESULTS: Alcohol-DEN mice showed higher ALTs than pair fed- DEN mice throughout the alcohol feeding without weight gain. Alcohol feeding resulted in increased ALT, liver steatosis and inflammation compared to pair-fed controls. Alcohol-DEN mice had reduced steatosis and increased fibrosis indicatingadvanced liver disease. Molecular characterization showed high estlevels of both neutrophil and macrophage markers in alcohol-DEN livers. Importantly, M 2 macrophages were edominantly higher in alcohol-DEN livers. Magnetic resonance imaging revealed increased numbers of intrahepatic cysts and liver histology confirmed the presence of early HCC in alcohol-DEN mice compared to al l other groups. This correlated with increased serum alphafetoprotein, a marker of HCC, in alcohol-DEN mice. PCNA immunostaining revealed significantly increased hepatocyte proliferation in livers from alcohol-DEN compared to pair fed-DEN or alcohol-fed mice.CONCLUSION: We describe a new 12-wk HCC model in adult mice that develops in livers with alcoholic hepatitis and defines ALD as co-factor in HCC. | Aditya Ambade Abhishek Satishchandran Benedek Gyongyosi Patrick Lowe Gyongyi Szabo | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 4 | A strategy for the development of biomarker tests for PTSD显示文摘 | Lei Zhang He Li David Benedek Xiaoxia Li Robert Ursano | 2009 | Medical Hypotheses2009，，3： | 2 |
| 5 | Intelligence,creativity,and cognitive control:The common and differential involvement of executive functions in intelligence and creativity显示文摘 | Benedek M Jauk E Sommer M | 2014 | Intelligence2014，46，1： | 1 |
| 6 | Use of TTC staining for the evaluation of tissue injury in the early phases of reperfusion after focal cerebral ischemia in rats 显示文摘 | Benedek A Moricz K Juranyi Z | 2006 | Brain Res2006，1116，1： | 1 |
| 7 | Late maturation of vis- ual spatial integration in humans 显示文摘 | Kovacs I Kozma P Feher A Benedek G | 1999 | Proc Natl Acad Sci USA1999，95，12： | 1 |
| 8 | Normal and abnormal develop- ment of visual functions in children显示文摘 | Kozma P Kovacs I Benedek G | 2001 | Acta Biologica Szegedi- ensis2001，45，14： | 1 |
| 9 | Suction- lift sludge removal and non-Newtonian flow behaviour in circular secondary clarifiers: Numerical modelling and measurements 显示文摘 | Michael Weiss Benedek Gy Prosz Karim E ssemiani | 2007 | Chemical Engineering Journal2007，132，： | 1 |
| 10 | Psychiatry and the military: an update显示文摘 | Ritchie E C Benedek D Malone R | 2006 | Psychiatry Clin North Am2006，29，3： | 1 |
| 11 | Cell therapy for human ischemic heart diseases: Critical review and summary of the clinical experiences显示文摘 | Noemi Pavo Silvia Charwat Noemi Nyolczas András Jakab Zsolt Murlasits Jutta Bergler-Klein Mariam Nikfardjam Imre Benedek Teodora Benedek Imre J. Pavo Bernard J. Gersh Kurt Huber Gerald Maurer Mariann Gy?ngy?si | 2014 | Journal of Molecular and Cellular Cardiology2014，，： | 1 |
| 12 | Feather degradation with a thermotolerant Streptomyces graminofaciens strain 显示文摘 | Szabo I Benedek A Mihaly Szabo I | 2000 | World Journal of Microbiology and Biotechnology2000，16，3： | 1 |
| 13 | Long-term follow-up of pacemaker lead systems: establishment of standards of quality 显示文摘 | FURMAN S BENEDEK Z M ANDREWS C A | 1995 | PACE1995，18，： | 1 |
| 14 | The Gravitational Poten- tial and its Derivatives for the Prisrn显示文摘 | D Nagy G Papp J Benedek | 2000 | Journal of Ge- odesy2000，74，78： | 1 |
| 15 | Despersion strengthered gold-platinum显示文摘 | Heywood A E Benedek R A | 1982 | Platinum Metals Review1982，26，3： | 1 |
| 16 | The space L^p with mixed norm显示文摘 | BENEDEK A PANZONE R | 1961 | Duke Math J1961，28，： | 1 |
| 17 | Sertraline for treatment of Pathological Crying显示文摘 | Benedek DK Peterson KA | 1995 | Am J Psychiatry1995，152，6： | 1 |
| 18 | Headache: diagnosis andtreatment显示文摘 | Benedek K Tajti J Vecsei L | 2006 | Orv Hetil2006，，37： | 1 |
| 19 | Convolution operators on Banach space valued functions显示文摘 | Benedek A Calder6n A P Panzone R | 1962 | Proc Nat Acad Sci USA1962，48，： | 1 |
| 20 | Why the eye lens is transparent 显示文摘 | Benedek G | 1983 | Nature1983，302，： | 1 |
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