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| 1 | Targeting head and neck tumoral stem cells: From biologicalaspects to therapeutic perspectives显示文摘Head and neck squamous cell cancer(HNSCC) is the sixth most common cancer in the world. Effective therapeutic modalities such as surgery, radiation, chemotherapy and combinations of each are used in the management of the disease. In most cases, treatment fails to obtain total cancer cure. In recent years, it appears that one of the key determinants of treatment failure may be the presence of cancer stem cells(CSCs) that escape currently available therapies. CSCs form a small portion of the total tumor burden but may play a disproportionately important role in determining outcomes. CSCs have stem features such as self-renewal, high migration capacity, drug resistance, high proliferation abilities. A large body of evidence points to the fact that CSCs are particularly resistant to radiotherapy and chemotherapy. In HNSCC, CSCs have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis and treatment resistance. In the light of such observations, the present review summarizes biological characteristics of CSCs in HNSCC, outlines targeted strategies for the successful eradication of CSCs in HNSCC including targeting the self-renewal controlling pathways, blocking epithelial mesenchymal transition, niche targeting, immunotherapy approaches and highlights the need to better understand CSCs biology for new treatments modalities. | Benoîte Méry Jean-Baptiste Guy Sophie Espenel Anne-Sophie Wozny Stéphanie Simonet Alexis Vallard Gersende Alphonse Dominique Ardail Claire Rodriguez-Lafrasse Nicolas Magné | 2016 | World Journal of Stem Cells2016，8，1： | 3 |
| 2 | Vacuum sealing in the treatment and prevention of prosthetic infections-a case review显示文摘 | Beno M Martin J Hatzl J | 2010 | Rozhl Chir2010，89，8： | 1 |
| 3 | Euglena gracilis as a supplementary test organism for detecting biologically active compounds显示文摘 | Macor M Beno J (3rones J | 1996 | Folia Microbiol1996，41，： | 1 |
| 4 | Treatment of reconstituted textile wastewater containing a reactive dye in an aerobic sequencing batch reactor using a novel bacterial consortium显示文摘 | Imen K Beno M Raja B A | 2012 | Separation and Purification Technology2012，87，： | 1 |
| 5 | Synthesis,characterization,and growth mechanism of n-type CuInS2 colloidal particles显示文摘 | Fabrice M C Royston W P Beno(i)t M | | 0，，16： | 1 |
| 6 | Oxygen Ordering and the Orthorhombic-to-Tetragonal Phase Transition in YBa2Cu3O7-x显示文摘 | Jorgensen J D Beno M A Hinks D G | | 0，，： | 1 |
| 7 | Multinucleate cells (MNC) as sensitive semiquantitative biomarkers of the toxic effect after experimental fibrous dust and cigarette smoke inhalation by rats显示文摘 | BENO M HURBANKOVA M DUSINSKA M | 2005 | Exp Toxicol Pathol2005，57，1： | 1 |
| 8 | Oxygen Ordering and the Orthorhombic-to-tetragonal Phase Transition in YBa2Cu3O7-x 显示文摘 | Jorgensen J D Beno M A Hinks D G | 1987 | Physical Review B1987，36，： | 1 |
| 9 | CFTR is a conductance regulator as well as a chloride channel 显示文摘 | Schwiebert EM Benos DJ Egan M E | 1999 | Physiol Rev1999，79，1： | 1 |
| 10 | Prevalence and Antimicrobial Resistance of Salmonella Isolated from Broiler Farms, Chicken Carcasses, and Street-Vended Restaurants in Casamance, Senegal显示文摘 | Dione Michel M Ieven Margareta Garin Beno?t Marcotty Tanguy Geerts Stanny | 2009 | Journal of Food Protection2009，，11： | 1 |
| 11 | Antibiotic prophylaxis for childhood urinary tract infection: a national survey 显示文摘 | Chevalier I Beno t G Gauthier M | 2008 | J Paediatr Child Health2008，44，10： | 1 |
| 12 | Endotoxin-induced hyperlactatemia results from decreased lactate clearance in hemodynamically stable rats显示文摘 | SEVERIN P N UHING M R BENO D W | 2002 | Crit Care Med2002，30，： | 1 |
| 13 | The ups and downs of peer review 显示文摘 | BENOS D J BASHARI E CHAVES J M etal | 2007 | Adv Physiol Educ2007，31，： | 1 |
| 14 | Vacuum sealing in the treatment and prevention of prosthetic infections--a case review显示文摘 | Beno M Martin J Hatzl J | 2010 | Rozhl Chir2010，89，8： | 1 |
| 15 | Vacuum assisted closure in vascular surgery 显示文摘 | Beno M Martin J Sager P | 2011 | Bratisl Lek Listy2011，112，5： | 1 |
| 16 | Private benefits and cross- listings in the United States 显示文摘 | BENOS E WEISBACHB M S | 2004 | Emerging markets re- view2004，，5： | 1 |
| 17 | Private Benefits and Cross-Listings in the United States显示文摘 | Benos E Weisbach M S | 2004 | Emerging Markets Review2004，5，2： | 1 |
| 18 | CFTRis a conductance regulator as well as a chloride channel 显示文摘 | Erik M Schwiebert D J Benos Marie E Egan | 1999 | Physiol Rev1999，79，1： | 1 |
| 19 | Surface roughness prediction using artificial neural networks when drilling Udimet 720 显示文摘 | VRABEL M MANKOVA I BENO J | 2012 | Procedia Engineering2012，48，： | 1 |
| 20 | Structure and Function of Amiloride Sensitive Epithelial Na^+ Channels 显示文摘 | Benos D J Awayda M S Ismailov I I | 1995 | J Membr Biol1995，143，： | 1 |
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