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| 1 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 2 | A pharmaco-genetics study of the human glucuronosyltransferase UGT1A4显示文摘 | BENOIT B MARIE O ADAM J P | 2009 | Pharm Genomics2009，19，12： | 1 |
| 3 | Runoff and soil erosion during spring thaw in the northern US Corn Belt显示文摘 | Sharratt B S Lindstrom M J Benoit G R | 2000 | Journal of Soil and Water Conservation2000，55，4： | 1 |
| 4 | Mercury methylation independent of the acetyl-coenzyme A pathway in sulfate-reducing bacteria显示文摘 | Ekstrom E B Morel F M M Benoit J M | 2003 | Applied and Environmental Microbiology2003，69，9： | 1 |
| 5 | Runoff and soil erosion during spring thaw in the northern US corn belt显示文摘 | SHARRATT B S LINDSTROM M J BENOIT G R | | 0，，04： | 1 |
| 6 | Gene transfer to intact mesen- teric arteries by electroporation显示文摘 | Martin J B Young J L Benoit J N | 2000 | J Vasc Res2000，37，5： | 1 |
| 7 | High re sistance to oxidative damage in the antarctic midge Belgica ant arctica, and developmentally linked expression of genes enco- ding superoxide dismutase, catalase and heat shock proteins显示文摘 | Lopez-Martinez G Elnitsky M A Benoit J B | 2008 | Insect Biochemistry and Molecular Biology2008，38，8： | 1 |
| 8 | Fractional brownian motion, fractional noises and application 显示文摘 | Mandelbrot Benoit B J W van Ness | 1968 | SIAM Review1968，10，： | 1 |
| 9 | Prolonged maintenance of water balance by adult females of the American spider beetle,mezium affine boieldieu,in the absence of food and water resources显示文摘 | Benoit J B Yoder J A Rellinger E J | 2005 | Journal of Insect Physiology2005，51，5： | 1 |
| 10 | High resistance to oxidative damage in the Antarctic midge Belgica antarctica, and developmentally linked expression of genes encoding superoxide dismutase, catalase and heat shock proteins显示文摘 | LOPEZ-MARTINEZ G ELNITSKY M A BENOIT J B | 2008 | Insect Biochem Mol Biol2008，38，： | 1 |
| 11 | Cardiac toxicity of intravenous erythromycin lactobionate in preterm infants 显示文摘 | GOUYON J B BENOIT A BETREMIEUX P | 1994 | Pediatr Infect Dis J1994，13，9： | 1 |
| 12 | Run- off and soil erosion during spring thaw in the northern US Corn Belt显示文摘 | Sharratt B S Lindstrom M J Benoit G R | 2000 | Journal of Soil and Water Conserva tion2000，55，4： | 1 |
| 13 | Elemental sulfur at the pyrite surfaces:speciation and quantification显示文摘 | Toniazzo V Mustin C Portal J M Humbert B Benoit R Erre R | 1999 | Applied Surface Science1999，143，3： | 1 |
| 14 | Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells显示文摘 | HELENE B J BENOIT L S HEATHER L T | 2004 | Clin Invest2004，114，7： | 1 |
| 15 | Fractional Brownian motions, fractional noises and applications显示文摘 | MANDELBROT B BENOIT B VAN NESS J W | 1968 | SIAM review1968，10，4： | 1 |
| 16 | Suppression of water loss dur-ing adult diapause in the northern house mosquito, Culex pipiens显示文摘 | Benoit J B Denlinger D L | 2007 | Journal of Experimental Biology2007，210，2： | 1 |
| 17 | Mercury cycling and effects in fresh water wetland ecosystems 显示文摘 | Zillious E L Porcella D B Benoit J M | 1993 | Environ Toxicol Chem1993，12，： | 1 |
| 18 | Parameters influencing the antigen release from spray-dried poly (DL-lactide) microparticles 显示文摘 | Baras B Benoit MA Gillard J | 2000 | Int J Pharm2000，200，1： | 1 |
| 19 | A surface acoustic wave mercury vapor sensor显示文摘 | Caron J J Haskell R B Benoit P | 1998 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control1998，45，5： | 1 |
| 20 | Binbibliometrics: Information Retrieval and Visualization from Co-Occurrences of Gene Names in Med- line Abstracts显示文摘 | Stapley B J Benoit G | 2000 | Pac Syrup Biocomput2000，，： | 1 |
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