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| 1 | Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis显示文摘AIM:To investigate the association of macrophage migration inhibitory factor(MIF)promoter polymorphisms with inflammatory bowel disease(IBD)risk.METHODS:One thousand and six New Zealand Caucasian cases and 540 Caucasian controls were genotyped for the MIF SNP-173G>C(rs755622)and the repeat polymorphism CATT5-8(rs5844572)using a predesigned TaqMan SNP assay and capillary electrophoresis,respectively.Data were analysed for single site and haplotype association with IBD risk and phenotype.Meta-analysis was employed,to assess cumulative evidence of association of MIF-173G>C with IBD.All published genotype data for MIF-173G>C in IBD were identified using PubMed and subsequently searching the references of all PubMed-identified studies.Imputed genotypes for MIF-173G>C were generated from the Wellcome Trust Case Control Consortium(and National Institute of Diabetes and Digestive and Kidney Diseases).Separate meta-analyses were performed on Caucasian Crohn’s disease(CD)(3863 patients,6031controls),Caucasian ulcerative colitis(UC)(1260 patients,1987 controls),and East Asian UC(416 patients and 789 controls)datasets using the Mantel-Haenszel method.The New Zealand dataset had 93%power,and the meta-analyses had 100%power to detect an effect size of OR=1.40 atα=0.05,respectively.RESULTS:In our New Zealand dataset,single-site analysis found no evidence of association of MIF polymorphisms with overall risk of CD,UC,and IBD or disease phenotype(all P values>0.05).Haplotype analysis found the CATT5/-173C haplotype occurred at a higher frequency in New Zealand controls compared to IBD patients(0.6 vs 0.01;P=0.03,OR=0.22;95%CI:0.05-0.99),but this association did not survive bonferroni correction.Meta-analysis of our New Zealand MIF-173G>C data with data from seven additional Caucasian datasets using a random effects model found no association of MIF polymorphisms with CD,UC,or overall IBD.Similarly,meta-analysis of all published MIF-173G>C data from East Asian datasets(416UC patients,789 controls)found no association of this promoter polymorphism with UC. | James D Falvey Robert W Bentley Tony R Merriman Mark B Hampton Murray L Barclay Richard B Gearry Rebecca L Roberts | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 2 | NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease显示文摘AIM:To assess whether polymorphisms in NOD2 and ATG16L1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis (MAP) survival in monocytes from Crohn's disease (CD) patients.METHODS:Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16L1.Monocytes were challenged with MAP and bacterial persistence assessed at subsequent time-points.Cytokine responses were assayed using a Milliplex multi-analyte profiling assay for 13 cytokines.RESULTS:Monocytes heterozygous for a NOD2 polymorphism (R702W,P268S,or 1007fs) were more permissive for growth of MAP (P=0.045) than those without.There was no effect of NOD2 genotype on subsequent cytokine expression.The T300A polymorphism ofATG16L1 did not affect growth of MAP in our model (P=0.175),but did increase expression of cytokines interleukin (IL)-10 (P=0.047) and IL-6 (P=0.019).CONCLUSION:CD-associated polymorphisms affected the elimination of MAP fromex vivo monocytes (NOD2),or expression of certain cytokines (ATG16L1),implying independent but contributory roles in the pathogenesis of CD. | Dylan M Glubb Richard B Gearry Murray L Barclay Rebecca L Roberts John Pearson Jacqui I Keenan Judy McKenzie Robert W Bentley | 2011 | World Journal of Gastroenterology2011，17，23： | 2 |
| 3 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 4 | An algorithm for finding best matches in logari - thmic expected time 显示文摘 | Friedman J H Bentley J L Finkel R A | 1977 | ACM Transactions on Mathematical Software1977，，3： | 1 |
| 5 | Gestational diabetes mellitus: postpartum opportunities for the diagnosis and prevention of type 2 diabetes mellit 显示文摘 | Bentley L R Levkoff S Stuebe A | 2008 | Nat Clin Pract Endocrinol Metab2008，4，10： | 1 |
| 6 | Algorithms for reporting and counting geometric intersection显示文摘 | Bentley J L Ottmann T A | 1979 | IEEE Transactions on Computers1979，100，9： | 1 |
| 7 | Evaluation of topical nalbuphine or oral tramadol as analgesics for corneal pain in dogs: a pilot study 显示文摘 | CLARK J S BENTLEY E SMITH L J | 2011 | Vet Ophthalmol2011，14，6： | 1 |
| 8 | Multidimensional binary search trees used for asso- ciative searching显示文摘 | Bentley J L | 1975 | Commun ACM1975，18，9： | 1 |
| 9 | The effect of loop electrosurgical excision procedure on future pregnancy outcome显示文摘 | Samson S L Bentley I B Fahey T J | 2005 | Obstet Gynecol2005，105，2： | 1 |
| 10 | Optimal expected time algorithms for closest point problems显示文摘 | BENTLEY J L WEIDE B W YAO A C | 1980 | ACM Transactions on Mathematical Software1980，6，4： | 1 |
| 11 | Multidimensional binary search trees used for associative searching显示文摘 | Bentley J L | | 0，，09： | 1 |
| 12 | Concurrent Cloud-to-Ground Lightning and Precipitation Enhancement in the Atlanta, Georgia (United States), Urban Region显示文摘 | Rose L. S. Stallins J. A. Bentley M. L | 2008 | Earth Interactions2008，，11： | 1 |
| 13 | Multidimensional Binary Search Trees Used for Associative Searching显示文摘 | BENTLEY J L | 1975 | Communications of the ACM1975，18，9： | 1 |
| 14 | MuLtiDiMENSiONAL BiNARy SEARCh tREESuSED fOR ASSOCiAtivE SEARChiNg显示文摘 | BENTLEY J L | 1975 | COMMuNiCAtiONS OfthE ACM1975，18，9： | 1 |
| 15 | The Effect of Machining on the Fatigue Strength of Y -- TiAl Intermetallic Alloy 显示文摘 | Bentley S A Mantle A L Aspinwall D K | 1999 | Intermetallies1999，7，8： | 1 |
| 16 | Multidimensional binary search trees used for asso- ciative searching显示文摘 | Bentley J L | 1975 | Communications of the ACM1975，18，9： | 1 |
| 17 | Algorithms for Repor- ting and Counting Geometric Intersections 显示文摘 | Bentley J L Ottmann T A | 1979 | IEEE Transactions on Computers1979，28，9： | 1 |
| 18 | Multidimensional binary search trees used for associative searching 显示文摘 | BENTLEY J L | 1975 | Communications of the ACM1975，18，9： | 1 |
| 19 | Data structure for range searching显示文摘 | Frieman J H | 1979 | ACM Computer Surveys1979，11，4： | 1 |
| 20 | Quadtrees:A data structure for retrieval on compositive keys显示文摘 | Finkel R A Bentley J L | 1974 | Acta Informatic1974，4，1： | 1 |
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