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19篇 您的检索式：作者名="Beom H G"

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		题名	作者	年代	出处	被引量
	1	4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells.	Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon	2017	Cellular & Molecular Immunology2017，14，9：	6
	2	Numerical simulation of explosive welding using the material point method显示文摘	Wang Y X H G Beom Sun M		0，，：	1
	3	Micro-frictional dissipation in fiber-reinforced ceramic matrix composites and interfacial shear estimation with a consideration of uneven fiber packing显示文摘	Cho C Choi E Y Beom H G	2005	Journal of Materials Processing Technology2005，16，：	1
	4	Near-tip fields and intensity factors for interfacial cracks in dissimilar anisotropic piezoelectric media显示文摘	Beom H G Atluri S N	1996	International Journal of Fracture1996，75，2：	1
	5	Antioxidant effects of Lcarnosine on liposomes and beef homogenates显示文摘	Beom J L Deloy G H	1997	Food Science1997，62，5：	1
	6	Numerical simulation of explosive welding using the material point method显示文摘	WANG Yu-xin Beom H G SUN Ming LIN Song	2011	International Journal of Impact Engineering2011，38，1：	1
	7	Asymptotic analysis of an impermeable crack in an electrostrictive material subject- ed to electric loading显示文摘	Beom H G Kim Y H Cho C	2006	International Journal of Solids and Structures2006，43，2223：	1
	8	Rate-dependent large deformation behavior 显示文摘	Qin Z F Wang T J Beom H G	2009	Polymer2009，50，12：	1
	9	Cale-ulation of stress intensity factors for an interracial crack between dissimilar aniso-tropie media, using a hybrid element methodand the mutual integral 显示文摘	Chow W T Beom H G Atluri S N	1995	Computational Mechanics1995，15，：	1
	10	Near-tip fields and intensity factors for interfacial cracks in dissimilar anisotropic piezoelectric media 显示文摘	Beom H G Atluri S N	1996	International Journal Fracture1996，75，：	1
	11	Numerical simulation of explosive welding using the material point method 显示文摘	Wang Y X Beom H G Sun M	2011	International Journal of Impact Engineering2011，38，：	1
	12	Numerical simulation of explosive welding using the material point method显示文摘	Wang Yuxin Beom H G Sun Ming		0，，：	1
	13	Effect of cyclic loading on tensile properties of PC and PC/ABS显示文摘	Fang Q Z Wang T J Beom H G Li H M	2008	Polymer Degradation and Stability2008，93，14：	1
	14	Conducting cracks in dissimilar piezoelectric media显示文摘	BEOM H G ATLURI S N	2000	Inter J Fracture2000，118，：	1
	15	Application of an orthotropy resealing method to edge cracks and kinked cracks in orthotropic two dimensional sol- ids显示文摘	H G Beom C B Cui H S Jang	2012	Engineering Seienee2012，51，：	1
	16	Finite Element Analysis of Nonuniformity of Tires with Imperfections 显示文摘	K M Jeong K W Kim H G Beom	2007	Tire Science and Teehnology(S0090-8657)2007，35，3：	1
	17	Edge delamination in an orthotropic bimaterial consisting of a thin film and a substrate 显示文摘	LEE G H CUI C B BEOM H G	2014	Acta Mech2014，225，：	1
	18	Crack growthin ferroelectric ceramics under electric loading显示文摘	Incheon Jeong K M	2005	Acta Mechanica2005，177，：	1
	19	Phytic acid protective effect against beef round muscle lipid peroxidation 显示文摘	BEOM J L DELOY G H	1995	Journal of Food Science1995，2，：	1

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