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| 1 | Post-transplant diabetes mellitus and preexisting liver disease-a bidirectional relationship affecting treatment and management显示文摘Liver cirrhosis and diabetes mellitus(DM)are both common conditions with significant socioeconomic burden and impact on morbidity and mortality.A bidirectional relationship exists between DM and liver cirrhosis regarding both etiology and disease-related complications.Type 2 DM(T2DM)is a wellrecognized risk factor for chronic liver disease and vice-versa,DM may develop as a complication of cirrhosis,irrespective of its etiology.Liver transplantation(LT)represents an important treatment option for patients with end-stage liver disease due to non-alcoholic fatty liver disease(NAFLD),which represents a hepatic manifestation of metabolic syndrome and a common complication of T2DM.The metabolic risk factors including immunosuppressive drugs,can contribute to persistent or de novo development of DM and NAFLD after LT.T2DM,obesity,cardiovascular morbidities and renal impairment,frequently associated with metabolic syndrome and NAFLD,may have negative impact on short and long-term outcomes following LT.The treatment of DM in the context of chronic liver disease and post-transplant is challenging,but new emerging therapies such as glucagon-like peptide-1 receptor agonists(GLP-1RAs)and sodium–glucose cotransporter 2 inhibitors(SGLT2i)targeting multiple mechanisms in the shared pathophysiology of disorders such as oxidative stress and chronic inflammation are a promising tool in future patient management. | Maja Cigrovski Berkovic Lucija Virovic-Jukic Ines Bilic-Curcic Anna Mrzljak | 2020 | World Journal of Gastroenterology2020，26，21： | 10 |
| 2 | 癫痫的ILAE分类:ILAE委员会关于分类和术语的意见书显示文摘自从1989年国际抗癫痫联盟(ILAE)最后批准的分类以来,ILAE已经更新了癫痫的分类,以反映我们在获得巨大科学进步后对癫痫及其基本机制理解方面的收获。作为执业医师的重要工具,在我们的思想中癫痫分类必须有恰当和动态的变化,并且应全面的翻译到全球所有地区。癫痫分类最初的目的是对患者进行诊断,但是对于癫痫研究、抗癫痫治疗的发展和全世界的交流也非常重要。这次新分类起源于2013年提交以供公开评论的一份草拟文件,该草拟文件在经过国际癫痫界几轮讨论广泛反馈后得以修订。此分类呈现了3个层次,首先是发作类型,假设患者已经有最新的2017年ILAE癫痫发作分类所确定的发作类型;诊断了发作类型后,下一步就是诊断癫痫类型,包括局灶性癫痫、全面性癫痫、全面性及局灶性癫痫两者兼有,以及分类不明的癫痫;第三层次是癫痫综合征,此处可以做出特定综合征的诊断。这一新分类在每一层次均包含了病因,强调在每一步诊断时都要考虑病因,因为病因将会对治疗产生重要影响。选择将病因分为6个亚组是基于其潜在的治疗因果关系。该分类引入了新的术语如'发育性和癫痫性脑病'等。'自限性'和'药物有效性'取代'良性'一词。希望这一新的框架将有助于提高21世纪癫痫的关爱和研究。 | Ingrid E Scheffer Samuel Berkovic Giuseppe Capovilla 张静 张月华 刘晓燕 吴逊 | 2018 | 癫痫杂志2018，4，6： | 4 |
| 3 | Exploring new treatment options for polycystic ovary syndrome: Review of a novel antidiabetic agent SGLT2 inhibitor显示文摘Polycystic ovary syndrome(PCOS)is the most common endocrinopathy in women of reproductive age associated with long-term metabolic and cardiovascular consequences.A plethora of symptoms and their severity differentiate on an individual level,giving the syndrome numerous phenotypes.Due to menstrual cycle abnormalities,women suffer from irregular menstrual bleeding,difficulty in conception,and infertility.Furthermore,the risk of pregnancy complications such as gestational diabetes mellitus,hypertensive disorders of pregnancy,and preterm birth are higher in women with PCOS than in the general population.Often,women with PCOS have comorbidities such as dyslipidemia,obesity,glucose intolerance or diabetes type 2,non-alcoholic fatty liver disease,and metabolic syndrome,which all influence the treatment plan.Historic insulinsensitizing agents,although good for some of the metabolic derangements,do not offer long-term cardiovascular benefits;therefore,new treatment options are of paramount importance.Sodium-glucose co-transporter-2(SGLT-2)inhibitors,a new class of antidiabetic agents with beneficial cardiovascular,bodyweight,and antihyperglycemic effects,although not approved for the treatment of PCOS,might be an attractive therapeutic addition in the PCOS armamentarium.Namely,recent studies with SGLT-2 inhibitors showed promising improvements in anthropometric parameters and body composition in patients with PCOS.It is important to further explore the SGLT-2 inhibitors potential as an early therapeutic option because of the PCOS-related risk of metabolic,reproductive,and psychological consequences. | Jelena Marinkovic-Radosevic Maja Cigrovski Berkovic Egon Kruezi Ines Bilic-Curcic Anna Mrzljak | 2021 | World Journal of Diabetes2021，12，7： | 3 |
| 4 | Coagulation and Endothelial Dysfunction Associated with NAFLD:Current Status and Therapeutic Implications显示文摘Non-alcoholic fatty liver disease(NAFLD)is closely related to insulin resistance,type 2 diabetes mellitus,and obesity.It is nowadays considered a multisystem disease with a strong association with cardiovascular disease and arterial hypertension,which interfere with changes in the coagulation system.Coagulation disorders are common in patients with hepatic impairment and are dependent on the degree of liver damage.Patients with NAFLD may have preserved overall hemostatic profile,but many studies suggest a trend toward a procoagulant state.Hypercoagulable state in NAFLD patients may even induce progression of hepatic injury.Endothelial dysfunction is present in the systemic and portal vein circulation in NAFLD patients,and platelets are being recognized as modulators of liver diseases through various mechanisms.Through a literature review,we discuss possible disorders in the coagulation cascade and fibrinolysis,endothelial dysfunction,and platelet abnormalities in patients with NAFLD.Considering the processes and mechanisms involved in the hemostatic abnormalities associated with NAFLD,directly related to liver disease or indirectly related through inflam-matory processes and metabolic disorders,several potential therapeutic targets have been identified and reviewed here. | Doris Ogresta Anna Mrzljak Maja Cigrovski Berkovic Ines Bilic-Curcic Sanja Stojsavljevic-Shapeski Lucija Virovic-Jukic | 2022 | Journal of Clinical and Translational Hepatology2022，10，2： | 3 |
| 5 | Spiropyrans and spirooxazines for memories and switches显示文摘 | Berkovic G Krongauz V Weiss V | 2000 | Chemical Reviews2000，100，5： | 1 |
| 6 | Febrile seizures:genetics and relationship to other epilepsy syndromes显示文摘 | Berkovic S F Scheffer I E | 1998 | Curr Opin Neurol1998，11，： | 1 |
| 7 | Kufs disease: A critical reappraisal显示文摘 | Berkovic SF Varpenter S Anderman | 1988 | Brain1988，111，1： | 1 |
| 8 | New therapcutic opportunities in epilepsy: A genetic perspective 显示文摘 | Reid C A Jackson G D Berkovic S F | 2010 | Pharmacol Ther2010，1289，2： | 1 |
| 9 | Mechanisms of human inherited epilepsies 显示文摘 | Reid C A Berkovic S F Petrou S | 2009 | Prog Neurobiol2009，87，1： | 1 |
| 10 | Familial temporal lobe epilepsy: a common disorder identified in twins 显示文摘 | Berkovic SF Mclntosh A Howell RA | 1996 | Ann Neurol1996，40，： | 1 |
| 11 | Risk factors for sudden unexpected death in epilepsy: a confrolled, prospecuve study based on coroners cases显示文摘 | Opeskin K Berkovic SE | 2003 | Seizure2003，12，： | 1 |
| 12 | Revised terminology and concepts for organization of seizures and epilepsies:report of the ILAE Commission on Classification and Terminology, 2005-2009显示文摘 | Berg AT Berkovic SF Brodie MJ | 2010 | Epilepsia2010，51，4： | 1 |
| 13 | Generalized epilepsy with febrile seizures plus: a genetic disorder with heterogeneous clinical phenotypes显示文摘 | Scheffer IE Berkovic SF | 1997 | Brain1997，120，3： | 1 |
| 14 | Revised terminology and concepts for olganization of seizures and epilepsies : report of the ILAE Commission on Classification and Terminology, 2005-2009 显示文摘 | Berg AT Berkovic SF Brodie MJ | 2010 | Epi- lepsia2010，51，4： | 1 |
| 15 | Hippacampal pathology in refractory temporal lobe epilepsy T2-weighted signal change reflects dentate gliosis显示文摘 | Briellmann RS Kalnins RM Berkovic SF | 2002 | Neurology2002，58，2： | 1 |
| 16 | Properties of neuronal nicotinic acetylcholine receptor mutants from humans suffering from autosomal dominant nocturnal frontal lobe epilepsy 显示文摘 | Bertrand S Weiland S Berkovic SF | 1998 | Br J Pharmacol1998，125，4： | 1 |
| 17 | Human epileptogenesis and hypothalamic hamartomas:new lessons from an experiment of nature显示文摘 | Berkovic S F Kuzniecky R I Andermann F | | 0，，： | 1 |
| 18 | A new locus for generalized epilepsy with febrile seizures plus maps to chromosome 2 显示文摘 | Lopes-Cendes I Scheffer IE Berkovic SF | 2000 | Am J Genet2000，66，2： | 1 |
| 19 | nm23-H1 expression and loss of heterozygosity in colon adenocarcinoma显示文摘 | Kapitanovic S Cacev T Berkovic M | 2004 | J Clin Pathol2004，57，12： | 1 |
| 20 | Optimizing the diagnosis of hippocampal selerosis using MR imaging显示文摘 | Jackson GD Berkovic SF Duncan JS | 1993 | AJNR1993，14，： | 1 |
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