|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intensified chemotherapy with ACVBP plus rituximab versus standard CHOP plus rituximab for the treatment of diffuse large B-cell lymphoma (LNH03-2B): an open-label randomised phase 3 trial显示文摘 | Christian Récher Bertrand Coiffier Corinne Haioun Thierry Jo Molina Christophe Fermé Olivier Casasnovas Catherine Thiéblemont André Bosly Guy Laurent Franck Morschhauser Hervé Ghesquières Fabrice Jardin Serge Bologna Christophe Fruchart Bernadette Corront | 2011 | 2011 (9806)2011，，9806： | 2 |
| 2 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 3 | Sequence of the sheep interleukin - 10 encoding Cdna显示文摘 | BERNADETTE M DUTIA P H DAVID R S | 1994 | Gene1994，149，： | 1 |
| 4 | Codon usage in plastid genes is correlated with context, position within the gene, and amino acid content 显示文摘 | Morton B R Bernadette G | 2000 | Molecular Evolution2000，50，2： | 1 |
| 5 | On the confirmability and disconfirmability of trait concept 显示文摘 | Myron R Bernadette P | 1986 | Journal of Personality and Social Psychology1986，，50： | 1 |
| 6 | Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite显示文摘 | Abdul R Maher Sayqa Arif Melanie Madhani Khalid Abozguia Ibrar Ahmed Bernadette O Fernandez Martin Feelisch AG O’Sullivan Arthur Christopoulos Aaron L Sverdlov Doan Ngo Rustem Dautov Philip E James John D Horowitz Michael P Frenneaux | 2013 | Br J Pharmacol2013，，3： | 1 |
| 7 | Regulation of zinc metabolism and genomic outcomes显示文摘 | Cousins R J Blanchard R K Bernadette Moore J | 2003 | J Nutr2003，133，： | 1 |
| 8 | Intensified chemotherapy with ACVBP plus rituximab versus standard CHOP plus rituximab for the treatment of diffuse large B-cell lymphoma (LNH03-2B): an open-label randomised phase 3 trial显示文摘 | Christian Récher Bertrand Coiffier Corinne Haioun Thierry Jo Molina Christophe Fermé Olivier Casasnovas Catherine Thiéblemont André Bosly Guy Laurent Franck Morschhauser Hervé Ghesquières Fabrice Jardin Serge Bologna Christophe Fruchart Bernadette Corront | 2011 | The Lancet . 2011 (9806)2011，，： | 1 |
| 9 | Analysis of fatty and nonfat foods for chlorophenoxy alkyl acids and pentachlorophenol显示文摘 | Marvin L Hoppep Bernadette McMahon Kenneth R | 1992 | AOAC1992，75，4： | 1 |
| 10 | Molecular weight determination of hydrolyzed collagens显示文摘 | Alain D Noelle B Bernadette D Sylviane G Claude R Nicole M Claude A | | 0，，6： | 1 |
| 11 | Management of neonatal abstinence syndrome in neonates born to opioid maintained women显示文摘 | Nina E Klaudia R Bernadette W | 2007 | Drug and Alcohol Dependence2007，3，： | 1 |
| 12 | ADP-ribosy-lation of human defensin HNP-1 results in the replace-ment of the modified arginine with the noncoded aminoacid ornithine显示文摘 | Linda A S Rodney L L Bernadette R | 2009 | PNAS2009，106，19： | 1 |
| 13 | A reliable morphological method to assess the age of male Anopheles gambiae显示文摘 | Bernadette J Huho Kija R Ng'habi Gerry F Killeen | 2006 | Malaria Journal2006，5，： | 1 |
| 14 | Use of carbon footprinting to explore alternative household waste policy scenarios in an Irish city -re- gion 显示文摘 | Divad Browen Bernadette O R Richard M | 2009 | Resource Conervation and Recycling2009，54，3： | 1 |
| 15 | Coaxial metal and magnetic alloy nanotubes in polycarbonate templates by electroless deposition 显示文摘 | F R James P C Declan M A Bernadette | 2008 | Electrochemistry Communications2008，10，： | 1 |
| 16 | Protection from pulmonary hypertension with an orally active endothelin receptor antagonist in hypoxic rats显示文摘 | Saadla E Bernadette R Martine C | 1995 | Am J Physiol Heart Circ Physiol1995，268，： | 1 |
| 17 | Protection from pulmonary hypertension with an orally active endothelin receptor antagonist in hypoxic rats 显示文摘 | Saadla E Bernadette R Martine C | 1995 | Am J Physiol Heart Circ Physiol1995，268，： | 1 |
| 18 | Cystic struma ova- rii presenting with ascitesand all elevated CA125 level a case report显示文摘 | Aqiba B Ginin S R Bernadette C | 2003 | Journal of Reproductive Medicine2003，48，： | 1 |
| 19 | Long-term outcomes after endoscopic removal of malignant colorectal polyps:Results from a 10-year cohort显示文摘BACKGROUND Choosing an optimal post-polypectomy management strategy of malignant colorectal polyps is challenging,and evidence regarding a surveillance-only strategy is limited.AIM To evaluate long-term outcomes after endoscopic removal of malignant colorectal polyps.METHODS A single-center retrospective cohort study was conducted to evaluate outcomes after endoscopic removal of malignant colorectal polyps between 2010 and 2020.Residual disease rate and nodal metastases after secondary surgery and local and distant recurrence rate for those with at least 1 year of follow-up were invest-igated.Event rates for categorical variables and means for continuous variables with 95%confidence intervals were calculated,and Fisher’s exact test and Mann-Whitney test were performed.Potential risk factors of adverse outcomes were RESULTS In total,135 lesions(mean size:22.1 mm;location:42%rectal)from 129 patients(mean age:67.7 years;56%male)were enrolled.The proportion of pedunculated and non-pedunculated lesions was similar,with en bloc resection in 82%and 47%of lesions,respectively.Tumor differentiation,distance from resection margins,depth of submucosal invasion,lymphovascular invasion,and budding were reported at 89.6%,45.2%,58.5%,31.9%,and 25.2%,respectively.Residual tumor was found in 10 patients,and nodal metastasis was found in 4 of 41 patients who underwent secondary surgical resection.Univariate analysis identified piecemeal resection as a risk factor for residual malignancy(odds ratio:1.74;P=0.042).At least 1 year of follow-up was available for 117 lesions from 111 patients(mean follow-up period:5.59 years).Overall,54%,30%,30%,11%,and 16%of patients presented at the 1-year,3-year,5-year,7-year,and 9-10-year surveillance examinations.Adverse outcomes occurred in 9.0%(local recurrence and dissemination in 4 patients and 9 patients,respectively),with no difference between patients undergoing secondary surgery and surveillance only.CONCLUSION Reporting of histological features and adherence to surveillance colonoscopy needs improvement.Long-term adverse outcome rates might be higher than previously reported,irrespective of whether secondary surgery was performed. | Anna Fábián Renáta Bor Béla Vasas Mónika Szűcs Tibor Tóth Zsófia Bősze Kata Judit Szántó Péter Bacsur Anita Bálint Bernadett Farkas Klaudia Farkas Ágnes Milassin Mariann Rutka Tamás Resál Tamás Molnár Zoltán Szepes | 2024 | World Journal of Gastrointestinal Endoscopy2024，16，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员