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| 1 | Endoscopic ultrasound-guided vs endoscopic retrograde cholangiopancreatography biliary drainage for obstructed distal malignant biliary strictures: A systematic review and meta-analysis显示文摘BACKGROUND For palliation of malignant biliary obstruction(MBO), the gold-standard method of biliary drainage is endoscopic retrograde cholangiopancreatography(ERCP)with the placement of metallic stents. Endoscopic ultrasound(EUS)-guided drainage is an alternative that is typically reserved for cases of ERCP failure.Recently, however, there have been robust randomized clinical trials(RCTs)comparing EUS-guided drainage and ERCP as primary approaches to MBO.AIM To compare EUS guidance and ERCP in terms of their effectiveness and safety in palliative biliary drainage for MBO.METHODS This was a systematic review and meta-analysis, in which we searched the MEDLINE, Excerpta Medica, and Cochrane Central Register of Controlled Trials databases. Only RCTs comparing EUS and ERCP for primary drainage of MBO were eligible. All of the studies selected provided data regarding the rates of technical and clinical success, as well as the duration of the procedure, adverse events, and stent patency. We assessed the risk of biases using the Jadad score and the quality of evidence using the Grading of Recommendations Assessment,Development and Evaluation criteria.RESULTS The database searches yielded 5920 records, from which we selected 3 RCTs involving a total of 222 patients(112 submitted to EUS and 110 submitted to ERCP). In the EUS and ERCP groups, the rate of technical success was 91.96%n and 91.81%, respectively, with a risk difference(RD) of 0.00%(95%CI:-0.07, 0.07;P = 0.97; I^2 = 0%). The clinical success was 84.81% and 85.53% in the EUS and ERCP groups, respectively, with an RD of-0.01%(95%CI:-0.12, 0.10; P = 0.90; I^2 =0%). The mean difference(MD) for the duration of the procedure was-0.12%(95%CI:-8.20, 7.97; P = 0.98; I^2 = 84%). In the EUS and ERCP groups, there were14 and 25 adverse events, respectively, with an RD of-0.06%(95%CI:-0.23, 0.12; P= 0.54; I^2 = 77%). The MD for stent patency was 9.32%(95%CI:-4.53, 23.18; P =0.19; I^2 = 44%). The stent dysfunction rate was significantly lower in the EUS t group(MD =-0.22%; 95 CI:-0.35,-0.08; P = 0.001; I^2 = 0%).CONCLUSION EUS represents an interesting alternative to ERCP for MBO drainage,demonstrating lower stent dysfunction rates compared with ERCP. Technical and clinical success, duration, adverse events and patency rates were similar. | Fernanda P Logiudice Wanderlei M Bernardo Facundo Galetti Vitor M Sagae Carolina O Matsubayashi Antonio C Madruga Neto Vitor O Brunaldi Diogo T H de Moura Tomazo Franzini Spencer Cheng Sergio E Matuguma Eduardo G H de Moura | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，4： | 6 |
| 2 | lnsulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment显示文摘 | Angiolillo gJ Bernardo E Ramirez C | 2006 | Journal of the American College of Cardiology2006，48，： | 1 |
| 3 | Pellet: A practical OWL-DL reasoner显示文摘 | SIRIN E PARSIA B BERNARDO E C | 2007 | Web Semantics: Science Services and A- gents on the World Wide Web2007，5，2： | 1 |
| 4 | Feasibility oftransapical aortic valve implantation guided by intracardiao ultrasoundwithout angiography 显示文摘 | FERRARI E MARCUCCI C DI BERNARDO S | 2010 | J Thorac Cardiovasc Surg2010，140，2： | 1 |
| 5 | Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment显示文摘 | Angiolillo D J Bernardo E Ramirez C | 2006 | J Am Coil Cardiol2006，48，2： | 1 |
| 6 | Cercical facet dislocation:techniques for ventral reduction and stabilization显示文摘 | Bernardo J Ordonez E C Benzel S N | 2000 | Neurosurgey2000，92，2： | 1 |
| 7 | Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment 显示文摘 | Angiolillo DJ Bernardo E Ramlrez C | 2006 | J Am Coil Cardiol2006，48，2： | 1 |
| 8 | Insulin therapy is associated with platelet dysfunction in patients with type 2diabetes mellitus on dual oral antiplatelet treatment显示文摘 | ANGIOLILLO D J BERNARDO E RAMIREZ C | 2006 | J Am Coll Cardiol2006，48，： | 1 |
| 9 | Insulin therapy is as- sociated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment 显示文摘 | Angiolillo D J Bernardo E Ramirez C | 2006 | J Am Coll Cardiol2006，48，2： | 1 |
| 10 | Platelet function profiles of clopidogrel hypo-responders identified following drug withdrawal (abstract)显示文摘 | Bernardo E Angiolillo DJ Ramirez-Guirao C | 2006 | Eur Heart J2006，27，： | 1 |
| 11 | Decolorization of molasses' wastewater using activated carbon prepared from cane bagasse 显示文摘 | BERNARDO E C EGASHIKA IL KAWASAKI J | 1997 | Carbon1997，35，9： | 1 |
| 12 | LAS glass-cera- mic scaffolds by three-dimensional printing 显示文摘 | Zocca A Comes C M Bernardo E | 2013 | J Eur Ce- ram Soc2013，33，9： | 1 |
| 13 | Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment 显示文摘 | Angiolillo DJ Bernardo E Ramirez C | 2006 | J Am Coll Cardiol2006，48，： | 1 |
| 14 | A genmne- wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia显示文摘 | Speedy H E Di Bernardo M C Sava G P | 2014 | Nat Genet2014，46，1： | 1 |
| 15 | Decolorization of molasses' wastewater using activated carbon prepared from cane bagasse显示文摘 | BERNARDO E C EGASHIRA R KAWASAKI J | 1997 | Carbon1997，35，9： | 1 |
| 16 | Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment显示文摘 | Angiolillo DJ Bernardo E Ramírez C | 2006 | J Am Coll Cardiol2006，48，2： | 1 |
| 17 | Decolorization of molasses' wastewater using activated carbon prepared from cane bagasse显示文摘 | Bernardo E C Egashira R Kawasaki J | 1997 | Carbon1997，35，9： | 1 |
| 18 | Decolorization of molasses wastewater using activated carbon prepared from cane bagasse显示文摘 | Bernardo E C Egashira R Kawasaki J | 1997 | Carbon1997，35，9： | 1 |
| 19 | Low-dose estrogen therapy does not change postexercise hypotension, sympathetic nerve activity reduction, and vasodilation in healthy postmenopausal women显示文摘 | Oneda B Forjaz C L Bernardo F R AratSjo T G Gusmao J L Labes E | 2008 | Am J Physiol Heart Circ Physiol2008，295，： | 1 |
| 20 | De-colorization of molasses' wastewater using activated carbon prepared from cane bagasse 显示文摘 | Bernardo E C Egashir A R Kawasakij | 1997 | Carbon1997，35，9： | 1 |
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