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| 1 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 2 | Physical activity and breast cancer risk among Asian-American women in LosAngeles: a case-control study显示文摘 | Yang D Bernstein L Wu AH | 2003 | Cancer2003，97，107： | 2 |
| 3 | Robust stability for sampled-data system显示文摘 | BERNSTEIN D S HOLLOT C V | 1989 | System & Control Letters1989，，13： | 2 |
| 4 | 生理性线粒体破碎是心脏适应能量需求增加的正常现象显示文摘线粒体在心脏中起着双重作用:负责满足能量需求和调节细胞凋亡。通常认为,线粒体的分裂和碎裂是病理性应激(如缺血)的结果,是线粒体质量差的指标,并导致线粒体自噬和细胞死亡。然而,最近的研究表明,抑制裂变也导致线粒体功能减弱和心脏损害,说明裂变对维持心脏和线粒体生物能量平衡十分重要。 | 刘莉 叶鹏 Coronado M Fajardo G Nguyen K Zhao M Kooiker KB Jung G Hu DQ Reddy S Sandoval E Stotland A Gottlieb RA Bernstein D | 2018 | 中华高血压杂志2018，26，1： | 2 |
| 5 | AML1,AML2 and AML3,the human members of the runt domain gene-family:cDNA structure,expression and chromosomal localization显示文摘 | Levanon D Negreanu V Bernstein Y | 1994 | Genomics1994，23，： | 1 |
| 6 | On uniqueness of entire functions in C^n and their partial differential polynomials显示文摘 | BERNSTEIN C A CHANG D C LIB Q | 1996 | Forum Math1996，8，： | 1 |
| 7 | A method of uniform stratification of risk for evaluating the results of surgery in acquired adultheartdisease显示文摘 | Parsonnet V Dean D Bernstein A D | 1989 | Circulation1989，79，62： | 1 |
| 8 | An RNA-directod nuclease mediates post-transcriptional gone silencing in Drosophila cells显示文摘 | Hammond SM Bernstein E Beach D | | 0，，6757： | 1 |
| 9 | The complexity of decentralized control of Markov decision processes显示文摘 | BERNSTEIN D S GIVAN R | 2002 | Mathematics of operations Research2002，27，4： | 1 |
| 10 | Compartmental Modeling and Second-moment Analysis of State Space Systems 显示文摘 | BERNSTEIN D S HYLAND D C | 1993 | SIAM J Matrix Anal1993，14，4： | 1 |
| 11 | Finite-time stability of continuous autonomous systems显示文摘 | Bhat S P Bernstein D S | 2000 | SIAM Journal of Control and Optimization2000，38，8： | 1 |
| 12 | An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells显示文摘 | Hammond S M Bernstein E Beach D | 2000 | Nature2000，404，： | 1 |
| 13 | Some map matching algorithms for personal navigation assistants 显示文摘 | WHITE C E BERNSTEIN D KORNHAUSER A L | 2000 | Transportation Research: Part C Emergency Technology2000，8，1： | 1 |
| 14 | Geometric homogeneity with applications to finite time stability显示文摘 | Bhat S Bernstein D | 2005 | Mathematics of Control Signals and Systems2005，17，2： | 1 |
| 15 | An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells显示文摘 | Hammond SM Bernstein E Beach D | 2000 | Nature2000，404，6775： | 1 |
| 16 | The genetic basis for the antigenicity of the VP2 protein of the infectious bursal disease virus显示文摘 | Schnitzler D Bernstein F Muller H | 1993 | J GenVirol1993，74，： | 1 |
| 17 | Finite-time stability of continuous autonomous systems显示文摘 | BHAT BERNSTEIN D | 2000 | SIAM Journal of Control and Optimization2000，38，3： | 1 |
| 18 | The traffic equilibrium problem with nonadditive path costs 显示文摘 | GABRIEL S BERNSTEIN D | 1997 | Transportation Science1997，31，4： | 1 |
| 19 | Continuous finite-time stabilization of the translational and rotational double integrators显示文摘 | Bhat S P Bernstein D S | 1998 | IEEE Transactions on Automatic Control1998，43，5： | 1 |
| 20 | Continuous finite-time stabilization of the translational and rotational double integrators 显示文摘 | Bhat S P Bernstein D S | 1998 | IEEE Transactions on Automatic Control1998，43，5： | 1 |
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