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| 1 | Near-infrared fluorescence imaging of a solitary fibrous tumor of the pancreas using methylene blue显示文摘A 67-year-old female presented with unexplained abdominal pain. A contrast-enhanced computed tomography scan of the abdomen incidentally revealed a mass in the uncinate process of the pancreas. This mass was resected and based on histopathological findings, diagnosed as a solitary fibrous tumor (SFT) of the pancreas. A SFT is an extremely rare benign mesenchymal tumor that in 65% of cases affects the visceral pleura but can also affect extra-pleural sites. The intraoperative demarcation of pancreatic tumors, such as SFTs, can bechallenging. In this report, the first clear intraoperative identification of a SFT of the pancreas in a human was shown using near-infrared fluorescence and methylene blue. | Joost R van der Vorst Alexander L Vahrmeijer Merlijn Hutteman Tjalling Bosse Vincent THBM Smit Cornelis JH van de Velde John V Frangioni Bert A Bonsing | 2012 | World Journal of Gastrointestinal Surgery2012，4，7： | 7 |
| 2 | Diagnosis of focal liver lesions with deep learning-based multichannel analysis of hepatocyte-specific contrast-enhanced magnetic resonance imaging显示文摘BACKGROUND The nature of input data is an essential factor when training neural networks.Research concerning magnetic resonance imaging(MRI)-based diagnosis of liver tumors using deep learning has been rapidly advancing.Still,evidence to support the utilization of multi-dimensional and multi-parametric image data is lacking.Due to higher information content,three-dimensional input should presumably result in higher classification precision.Also,the differentiation between focal liver lesions(FLLs)can only be plausible with simultaneous analysis of multisequence MRI images.AIM To compare diagnostic efficiency of two-dimensional(2D)and three-dimensional(3D)-densely connected convolutional neural networks(DenseNet)for FLLs on multi-sequence MRI.METHODS We retrospectively collected T2-weighted,gadoxetate disodium-enhanced arterial phase,portal venous phase,and hepatobiliary phase MRI scans from patients with focal nodular hyperplasia(FNH),hepatocellular carcinomas(HCC)or liver metastases(MET).Our search identified 71 FNH,69 HCC and 76 MET.After volume registration,the same three most representative axial slices from all sequences were combined into four-channel images to train the 2D-DenseNet264 network.Identical bounding boxes were selected on all scans and stacked into 4D volumes to train the 3D-DenseNet264 model.The test set consisted of 10-10-10 tumors.The performance of the models was compared using area under the receiver operating characteristic curve(AUROC),specificity,sensitivity,positive predictive values(PPV),negative predictive values(NPV),and f1 scores.RESULTS The average AUC value of the 2D model(0.98)was slightly higher than that of the 3D model(0.94).Mean PPV,sensitivity,NPV,specificity and f1 scores(0.94,0.93,0.97,0.97,and 0.93)of the 2D model were also superior to metrics of the 3D model(0.84,0.83,0.92,0.92,and 0.83).The classification metrics of FNH were 0.91,1.00,1.00,0.95,and 0.95 using the 2D and 0.90,0.90,0.95,0.95,and 0.90 using the 3D models.The 2D and 3D networks'performance in the diagnosis of HCC were 1.00,0.80,0.91,1.00,and 0.89 and 0.88,0.70,0.86,0.95,and 0.78,respectively;while the evaluation of MET lesions resulted in 0.91,1.00,1.00,0.95,and 0.95 and 0.75,0.90,0.94,0.85,and 0.82 using the 2D and 3D networks,respectively.CONCLUSION Both 2D and 3D-DenseNets can differentiate FNH,HCC and MET with good accuracy when trained on hepatocyte-specific contrast-enhanced multi-sequence MRI volumes. | Róbert Stollmayer Bettina K Budai Ambrus Tóth IldikóKalina Erika Hartmann Péter Szoldán Viktor Bérczi Pál Maurovich-Horvat Pál N Kaposi | 2021 | World Journal of Gastroenterology2021，27，35： | 6 |
| 3 | Surgical stress and cytoskeletal changes in lens epithelial cells following manual and femtosecond laser-assisted capsulotomy显示文摘AIM:To study the effect of mechanical stress on the cytoskeleton in lens epithelial cells following conventional phacoemulsification surgery(CPS)and femtosecond laserassisted cataract surgery(FLACS).METHODS:The cytoskeleton of the epithelial cells of the anterior lens capsules(ALC)removed by CPS and FLACS was examined by immunohistochemistry.Expression of the intermediate filament,glial fibrillary acidic protein(GFAP),and glutamine synthetase(GS)immunoreactivity were detected.In order to map the actin network of cells,fluorescently labeled phalloidin was used.The samples were examined using confocal laser scanning microscopy.RESULTS:GFAP expression was visible in a larger number of the epithelial cells after CPS compared to FLACS.In CPS sample’s epithelial cells,GFAP immunoreactivity indicated robust morphological change.Regarding the actin filaments,the presence of tubular elements connecting epithelial cells,regular actin pattern and marked cortical network after CPS were found.Following FLACS,the actin cytoskeleton of the epithelial cells remained densely structured,and the tubular elements were undetectable,however,the above-mentioned regular actin pattern and the marked cortical network were visible.CONCLUSION:The conventional removal of the ALC induces more robust changes of the cytoskeleton of the lens epithelial cells. | ANDrea Krisztina Sükosd Krisztina Szabadfi Edina Szabó-Meleg Beáta Gáspár Pavel Stodulka Gyorgy SétálóJr Róbert Gábriel Miklós Nyitrai Zsolt Biró Hajnalka Abrahám | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 2 |
| 4 | Dioxin emissions after installation of a polishing wet scrubber in a hazardous waste incineration facility显示文摘 | Carl-Johan L Bert B V | 2005 | Chemosphere2005，61，3： | 1 |
| 5 | From gut to kidney: Transporting and metabolizing calcineurin-inhibitors in solid organ transplantation显示文摘 | No?l Knops Elena Levtchenko Bert van den Heuvel Dirk Kuypers | 2013 | International Journal of Pharmaceutics . 2013 (1-2)2013，，1： | 1 |
| 6 | Evaluating laboratory perform-ance on quality indicators with the six sigma scale 显示文摘 | NevalainenD Berte L Kraft C | 2000 | Arch PatholLab Med2000，124，4： | 1 |
| 7 | Early diagnosis of extrapul- monary tuberculosis by a new procedure combining broth culture and PCR 显示文摘 | Noussair L Bert F Leflon-Guibout V | 2009 | Journal of Clinical Microbiology2009，47，5： | 1 |
| 8 | Physical and bioticdrivers of plant distribution across estuarine salinity gradients显示文摘 | Crain C M Silliman B R Bertness S L | 2004 | Ecology2004，85，： | 1 |
| 9 | Modulation of transforming growth factor β response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts显示文摘 | Steven D Bert D Birgit L | 2000 | Hepatology2000，31，5： | 1 |
| 10 | Risk of hip/femur fracture afterstroke:a population-based case-control study显示文摘 | Sander P Arief L Bert L | 2009 | Stroke2009，40，： | 1 |
| 11 | Pharmacological pfinciplesunderlying oxygen-ozone therapy显示文摘 | Chelmi P Valdenassi L Berte F | 2001 | Riv Neuroradio12001，14，： | 1 |
| 12 | Agenoralized model for the prediction of lead body burdens 显示文摘 | BERT J L Van DUSEN L J GRACE J E | 1989 | Environ Res1989，48，： | 1 |
| 13 | Zinc tolerance and accumulation in metallicolons and nonmetallicolons populations of Arabidopsis halleri(brassicaceae)显示文摘 | Stafan L Bert V B | | 0，，： | 1 |
| 14 | Evaluating laboratoryperformance on quality indicators with the six scale 显示文摘 | Nevalainen D Berte L Kraft C | 2000 | Arch Pathol Lab Med2000，124，4： | 1 |
| 15 | Oxalipatin,in combination with 5-fluorouracil(5-Fu)and lencovorin(LV)in patients with advanceA or metastatic gastric cancer(A/MOC)显示文摘 | Cavanna L Berte R Bernuzzi P | 2003 | Proc Am Soc Clin Oncol2003，22，： | 1 |
| 16 | Music improves sleep quality in students显示文摘 | László Harmat Johanna Takács Róbert Bódizs | | 0，，03： | 1 |
| 17 | Pressure-volume relationship for rat dermis: Compression studies显示文摘 | Bert J L Reed R K | 1997 | Acta physiologica Scan- dinavica1997，160，1： | 1 |
| 18 | A fracture mechanics ap- proach to fatigue of heavily drawn steel wires显示文摘 | Kasper L Martine W Bert V | 2011 | Procedia Engi- neering2011，10，7： | 1 |
| 19 | BlockadeofNMDA-receptors or calcium - channels attemuates the ischaemia- evoked efflux of glutamate and phosphoethanolamine and depression of neuronal activity in rat organotypic hippocampal slice cultures显示文摘 | Robert F Bert L Stoppini L | 2002 | C R Biol2002，325，4： | 1 |
| 20 | The mir-200 family and mir-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1显示文摘 | GREGORY P A BERT A G PATERSON E L | 2008 | Nature Cell Biolo- gy2008，10，5： | 1 |
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