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| 1 | A low steady HBsAg seroprevalence is associated with a low incidence of HBV-related liver cirrhosis and hepatocellular carcinoma in Mexico: a systematic review显示文摘 | Sonia Roman Arturo Panduro Yadira Aguilar-Gutierrez Montserrat Maldonado Maclovia Vazquez-VanDyck Erika Martinez-Lopez Bertha Ruiz-Madrigal Zamira Hernandez-Nazara | 2009 | Hepatology International2009，，2： | 2 |
| 2 | 雌激素上调体外培养的子宫肌瘤平滑细胞中原纤维蛋白-1的表达显示文摘目的探讨卵巢激素是否影响体外培养的子宫肌瘤平滑肌细胞中(Fibrillin-1,FBN-1)mR-NA和蛋白的表达。方法10份子宫肌瘤及同源正常子宫平滑肌组织标本在术中被采集,游离的子宫肌瘤平滑肌细胞及同源正常子宫平滑肌细胞在含有10%的胎牛血清DMEM培养基中培养。在细胞达到70%融合时继续用无血清培养基培养48h,然后加入递增剂量的17β雌二醇(17-βestrodioal,E2)(0、0.1、1、10ng/ml)或E210ng/ml联合加入递增剂量的孕激素(0、1、10、100ng/ml)继续培养48h。采用实时荧光定量PCR、Western blot及荧光免疫组织化学方法探查FBN-1 mRNA和蛋白在体外培养的子宫肌瘤平滑肌细胞中的表达。结果免疫荧光组织化学染色显示FBN-1在子宫肌瘤平滑细胞及正常子宫平滑肌细胞中均有表达;E2呈剂量依赖性增加子宫肌瘤平滑细胞中FBN-1 mRNA和蛋白的表达,尤其在E2浓度增加为10ng/ml时,与对照组相比差异显著(P<0.05,P<0.01);而在E2联合不同剂量的孕激素的情况下对子宫平滑肌瘤细胞FBN-1 mRNA和蛋白表达无影响。结论雌激素增加体外培养的子宫肌瘤平滑细胞中FBN-1 mRNA和蛋白的表达。 | 赵扬玉 乔杰 Yan Wen Chen Bertha | 2007 | 中国妇产科临床杂志2007，8，2： | 2 |
| 3 | A novel method for evaluating microglial activation using ionized calcium-binding adaptor protein-1 staining:cell body to cell size ratio显示文摘Aim:The aim was to validate a newly developed methodology of semi-automatic image analysis to analyze microglial morphology as marker for microglial activation in ionized calcium-binding adaptor protein-1(IBA-1)stained brain sections.Methods:The novel method was compared to currently used analysis methods,visual characterization of activation stage and optical density measurement,in brain sections of young and aged rats that had undergone surgery or remained naïve.Results:The cell body to cell size ratio of microglia was strongly correlated to the visual characterization activation stage.In addition,we observed specific surgery and age-related changes in cell body size,size of the dendritic processes and cell body to cell size ratio.Conclusion:The novel analysis method provides a sensitive marker for microglial activation in the rat brain,which is quick and easy to perform and provides additional information about microglial morphology. | Iris Bertha Hovens Csaba Nyakas Regien Geertruida Schoemaker | 2014 | Neuroimmunology and Neuroinflammation2014，1，1： | 2 |
| 4 | Prevalence of sensitive skin and its biophysical response in a Mexican population显示文摘AIM: To describe the frequency and biophysical response of sensitive skin in Mexican subjects, using the lactic acid test.METHODS: The lactic acid stinging test was applied to 250 healthy volunteers, both sexes, 18 years of age or older, without any active dermatoses on the test site. Volunteers were university students, workers of public institutions, and general population from San Luis Potosi, Mexico. Participants were not excluded based on socioeconomic status. Demographic data were obtained through a questionnaire. Skin phototype was obtained through colorimetry. Subjects were randomized to receive 10% lactic acid on one nasolabial fold and placebo on the other side. The presence and intensity of adverse sensations, such as itching, burning, or stinging, was evaluated through a 10-point VisualAnalogue Scale(VAS) prior to treatment and at 3, 5, 8 and 10 min after the intervention. Subjects with a VAS of 2 or higher were considered positive for the test. A VAS lower than 2 was considered a normal response to skin manipulation. Simultaneously, biophysical changes and barrier function were assessed by colorimetry, transepidermal water loss(TEWL), and capacitance. To decrease measurement variations by skin manipulation, the nasolabial fold was segmented in four areas of 1 cm2 for each time measurement. Descriptive analyses were made using central tendency measures. Analyses of data were performed using two-tailed c2 test, Fisher's test, t-test, logistic regression, or Mann-Whitney U test for non-parametric values between groups. RESULTS: Of the included 246 subjects, 68% were women and the mean age was 32 years. The most frequent skin phototype was Ⅴ(ranges Ⅱ-Ⅴ). Thirty-six percent of the subjects identified themselves as having sensitive skin. Fifty-two percent of the subjects were positive to the lactic acid stinging test, with a mean VAS of 4.5 at 3 min. Subjects with the self-diagnosis of sensitive skin were more likely to be positive for the test(80% vs 36%, P < 0.001). Lighter skin phototypes(types Ⅱ and Ⅲ) showed a higher response to the test compared to darker skin tones(type Ⅴ; OR = 0.88, P < 0.001). There were no statistical differences in baseline biophysical measurements. At 3 min, TEWL was significantly higher in subjects positive to the test(27.5 vs 23.7, P < 0.05). At 5 min, TEWL and capacitance showed statistical differences(26.0 vs 22.4, P < 0.05, and 239 vs 179, P < 0.05, respectively). After 5 min, values tended to return to baseline levels in both groups.CONCLUSION: Sensitive skin is frequent in our population. Darker skin phototypes have a lower prevalence of this syndrome, probably due to inherent differences in skin barrier function. | Diana Hernández-Blanco Juan Pablo Castanedo-Cázares Adriana Ehnis-Pérez Isabel Jasso-ávila Luis Conde-Salazar Bertha Torres-álvarez | 2013 | World Journal of Dermatology2013，2，1： | 2 |
| 5 | 原纤维蛋白-1 mRNA和蛋白在子宫肌瘤组织中的表达显示文摘目的:探讨原纤维蛋白-1(fibrillin-1,FBN-1)mRNA和蛋白在子宫肌瘤组织中的表达及其与月经周期的关系。方法:50份子宫肌瘤及同源正常子宫平滑肌组织标本在术中被采集。根据月经周期及子宫内膜组织病理学检查分为增生期、分泌期及萎缩期。采用实时荧光定量PCR、Western blot分析及免疫组织化学方法检测FBN-1 mRNA和蛋白的表达。结果:免疫组织化学染色显示FBN-1在子宫肌瘤及正常子宫平滑肌组织的细胞外基质中均有较丰富的表达。FBN-1 mRNA和蛋白在增生期和分泌期中的子宫肌瘤组织中的表达均明显高于同源正常子宫平滑肌组织(P<0.01,P<0.05;P<0.01,P<0.05),而在绝经期中的子宫平滑肌瘤及正常子宫平滑肌组织的表达无明显差异。结论:FBN-1可能与子宫肌瘤的发生机制有关,并可能受激素调节的影响。 | 赵扬玉 乔杰 Yanwen Bertha Chen | 2007 | 实用妇产科杂志2007，23，1： | 1 |
| 6 | Elastolytic activity in women with stress urinary incontinence and pelvic organ prolapse显示文摘 | Bertha Chen Yah Wen Mary Lake Polan | 2004 | Neurourology and Urodynamics2004，23，： | 1 |
| 7 | Development of beta-cell mass in,fetuses of rats deprived of protein andlor energy in last trimester of pregnancy显示文摘 | Bertha E | 2002 | Am J Physiol Regul Integr Comp2002，283，3： | 1 |
| 8 | Eco - efficiency and SMEs in Nova Seotia,Canada显示文摘 | Raymond Aaron Booth Bertha Louis | 2006 | Journal of Clean- er Production2006，，27： | 1 |
| 9 | Food in early life stages of Dosidicus gigas (Cephalopoda: Ommastrephidae) from the Gulf of California, Mexico显示文摘 | Susana Camarillo-Coop César A. Salinas-Zavala Bertha E. Lavaniegos Unai Markaida | 2013 | Journal of the Marine Biological Association of the United Kingdom2013，，7： | 1 |
| 10 | Cervical cancer:screening and prevention显示文摘 | BERTHAS N MEHRDAD N | 2006 | Asian Pae J Cancer Prey2006，7，4： | 1 |
| 11 | Coping Strategies of Family Members of Hospitalized Psychiatric Patients显示文摘 | Phyllis M. Eaton Bertha L. Davis Pamela V. Hammond Esther H. Condon Zina T. McGee Demetrius Porche | 2011 | Nursing Research and Practice2011，，： | 1 |
| 12 | Regulatory T-Cell Generation and Kidney Allograft Tolerance Induced by Mesenchymal Stem Cells Associated With Indoleamine 2,3-Dioxygenase Expression显示文摘 | Wei Ge Jifu Jiang Jacqueline Arp Weihua Liu Bertha Garcia Hao Wang | 2010 | Transplantation2010，，12： | 1 |
| 13 | Recurrent hepatocellular carcinoma after transplantation: Use of a pathological score on explanted livers to predict recurrence显示文摘 | Jeremy R. Parfitt Paul Marotta Mohammed AlGhamdi William Wall Anand Khakhar Neville G. Suskin Douglas Quan Vivian McAllister Cam Ghent Mark Levstik Carolyn McLean Subrata Chakrabarti Bertha Garcia David K. Driman | 2007 | Liver Transpl2007，，4： | 1 |
| 14 | Electrochemical and spectroelectrochemical studies of cobalt salen and salophen as oxygen reduction catalysts 显示文摘 | Ortiz Bertha Su-Moon Park | 2000 | Bull Korean Chem Soc2000，21，4： | 1 |
| 15 | Lipid oxidative damage and distribution of inorganic arsenic and its metabolites in the rat nervous system after arsenite exposure: Influence of alpha tocopherol supplementation显示文摘 | Erika García-Chávez Ismael Jiménez Bertha Segura Luz M. Del Razo | 2006 | Neurotoxicology2006，，6： | 1 |
| 16 | Acupunc- ture for Postchemotherapy Fatigue: A Phase Ⅱ Study显示文摘 | Andrew J Vickers David J Straus Bertha Fearon | 2004 | J Clin Oncol2004，22，9： | 1 |
| 17 | Eco-efficiency and SMEs in Nova Scotia,Canada显示文摘 | Raymond C(o)té Aaron Booth Bertha Louis | | 0，，6： | 1 |
| 18 | Effect of introducing a cationic system into a thiol-ene photopolymerizable formulation显示文摘 | Ricardo Acosta Ortiz Bertha A Puente Urbina Liliana U Cabello Valdez | 2007 | J Polym Sci Part A: Polym Chem2007，45，： | 1 |
| 19 | Vehicle Operating, Accident and User Time Costs in Pavement Management Systems: Approach for Portuguese Conditions显示文摘 | Bertha Maria Batista dos Santos Luis Guilherme de Picado Santos Victor Manuel Pissarra Cavaleiro | 2011 | Journal of Civil Engineering and Architecture2011，5，8： | 1 |
| 20 | Endothelial dysfunction and cardiovascular risk factors显示文摘 | Femando GP Bertha ZG | 2009 | Diabetes Res Cli Pract2009，84，12： | 1 |
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