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| 1 | 高级别胶质瘤放、化疗耐药性可能与microRNAs相关(英文)显示文摘High-grade gliomas(HGGs) are malignant primary brain tumors of glial cell origin.Despite optimal course of treatment,including maximal surgical resection followed by adjuvant chemo-and/or radiotherapy,the prognosis still remains poor.The main reason is the commonly occurring chemo-and radioresistance of these tumors.In recent years,several signaling pathways,especially PI3K/AKT and ATM/CHK2/p53,have been linked to the resistance of gliomas.Moreover,additional studies have shown that these pathways are significantly regulated by microRNAs(miRNAs),short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis,proliferation,cell cycle,invasivity,and angiogenesis.MiRNAs are not only highly deregulated in gliomas,their expression signatures have also been shown to predict prognosis and therapy response.Therefore,they present promising biomarkers and therapeutic targets that might overcome the resistance to treatment and improve prognosis of glioma patients.In this review,we summarize the current knowledge of the functional role of miRNAs in gliomas resistance to chemo-and radiotherapy. | Besse A Sana J Fadrus P Slaby O | 2013 | 中华神经外科疾病研究杂志2013，12，2： | 3 |
| 2 | General self- imaging properties in NxN multimode interference couplers including phase relations显示文摘 | BACHMANN M BESSE P A MEICHIOR H | 1994 | Applied Optics1994，33，18： | 1 |
| 3 | A Review of Transparent and Artificial Boundary Conditions Techniques for Linear and Nonlinear Schrtidinger Equations 显示文摘 | Antoine X Arnold A Besse C | 2008 | Commun Comput Phys2008，4，4： | 1 |
| 4 | Applied ecology, in melon fly control显示文摘 | Nishida T Bess H A | 1950 | Journal of Economic Entomology1950，43，6： | 1 |
| 5 | Three distinct types of hotspots in the Earth's mantle显示文摘 | Courtillot V Davaille A Besse J | 2003 | Earth and Planetary Science Letters2003，205，： | 1 |
| 6 | Tracking system with five degrees of freedom using a 2d-array of hall sensors and a permanent magnet显示文摘 | Schlageter V Besse P A Popovic R S | 2001 | Sensors and Actuators A-Physical2001，92，13： | 1 |
| 7 | Pharmacokinetics and tolerability of anagrelide hydrochloride in young ( 18 - 50 years) and elderly ( 1> 65 years) patients with essential thrombocy- themia显示文摘 | Besses C Zeller W Alvarez - Larr6n A | 2012 | Int J Clin Pharmacol Ther2012，50，： | 1 |
| 8 | Differential regulation of matrix metalloproteinase associated with aging and hypertension in the rat heart显示文摘 | ROBERT V BESSES S SABRI A | 1997 | Lab Invest1997，76，5： | 1 |
| 9 | Pharmacokinetics and tolerability of anagrelide hydrochloride in young (18-50 years) and elderly ( >: 65 years) patients with essential thrombocythemia 显示文摘 | Besses C Zeller W Alvarez-Larrrn A | 2012 | Int J Clin Pharmacol Ther2012，50，11： | 1 |
| 10 | The evolving role of histology in the management of advanced non-small-cell lung cancer 显示文摘 | Langer C J Besse B Gualberto A | 2010 | J Clin Oncol2010，28，36： | 1 |
| 11 | 3xP3-EGFP maker facilitates screening for transgenic silkworm Bombyx moriL, from the embryonic stage onwards 显示文摘 | THOMAS J L DA ROCHA M BESSE A | 2002 | Insect Biochemistry and Molecular Biology2002，32，： | 1 |
| 12 | Recent studies on the abundance of the oriental and mediterranean fruit flies and the status of their parasites显示文摘 | Haramoto G H Bess H A | 1970 | Proceeding Hawaii Entomolog Society1970，20，： | 1 |
| 13 | Comparison of screening methods in the detection of bladder cancer显示文摘 | Ramakumar S Bhuiyan J Besse J A | 1999 | J Urol1999，161，： | 1 |
| 14 | Differential regulation of matrix metalloproteinases associated with aging and hypertension in the rat heart显示文摘 | ROBERT V BESSE S SABRI A | 1997 | Lab Inv1997，76，： | 1 |
| 15 | Major vascular complications in essential thrombocythemia:a study of the predictive factors in a series of 148 patients显示文摘 | Besses C Cervantes F Pereira A | 1999 | Leukemia1999，13，： | 1 |
| 16 | Cerebrovascular disease as the initial clinical presentation of haematological disorders显示文摘 | Arboix A Besses C | 1997 | Eur Neurol1997，37，4： | 1 |
| 17 | The future of magnetic sensors 显示文摘 | Popovie R S Flanagan J A Besse P A | 1996 | Sensors Actuators A1996，56，： | 1 |
| 18 | Three distinct types of hotspots in the Earth' s mantle显示文摘 | Courtillot V Davaille A Besse J | 2003 | Earth and Planetary Science Letters2003，205，3： | 1 |
| 19 | The Future of Magnetic Sensors显示文摘 | Popovic R S Flanagan J A Besse P A | 1996 | Sensors and Actuators A1996，56，12： | 1 |
| 20 | Outcomes After Treatment of High-energy Tibial Plafond Fractures显示文摘 | Pollak A W McCarthy M L Bess R S | 2003 | J Boue Joint Surg (Am)2003，85，： | 1 |
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