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| 1 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 2 | Lactation curve in Malabari goats and their Saanen half-breds显示文摘 | MUKUNDAN G BHAT P N | 1983 | Indian Journal of Animal Sciences1983，53，： | 1 |
| 3 | Efficient Prins cyclization in environmentally benign method using ion exchange re- sin catalyst显示文摘 | More G P Rane M Bhat S V | 2012 | Green Chem Lett Rev2012，5，1： | 1 |
| 4 | The protein data bank显示文摘 | Berman H M Westbrook J Feng Z K Gilliland G Bhat T N Weissig H Shindyalov L N Bourne P E | | 0，，01： | 1 |
| 5 | Safety and efficacy of low-fluence, high-repetition rate versus high-fluence, low- repetition rate 810-nm diode laser for permanent hair remov- al--a split-face comparison study 显示文摘 | Pal G S Bhat P S Mallya H | 2011 | J Cosmet Laser Ther2011，13，4： | 1 |
| 6 | Valuable components of raw and ripe peels from two Indian mango varieties显示文摘 | AJILA C M BHAT S G UJ S P RAO | 2007 | Food Chemistry2007，，102： | 1 |
| 7 | Discovery of intense gamma-ray flashes of atmospheric origin 显示文摘 | Fishman G I Bhat P N Mallozzi R | 1994 | Science1994，264，： | 1 |
| 8 | Novel anticancer compounds induce apoptosis in melanoma cells 显示文摘 | Bhat U G Zipfel P A Tyler D S | 2008 | Cell Cycle2008，，： | 1 |
| 9 | Development of a graded TiCN coating for cemented carbide cutting tools-a design approach显示文摘 | Boppana P S Bhat D G | 1995 | Wear1995，188，12： | 1 |
| 10 | A preliminary in- vestigation of the effect of post-deposition polishing of dia- mond films on the machining behavior of diamond-coated cutting tools 显示文摘 | Bhat D G Johnson D G Malshe A P | 1995 | Diamond & Related Materials1995，4，7： | 1 |
| 11 | NF - kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4 显示文摘 | Helbig G Christopherson KW 2nd Bhat - Nakshatri P | 2003 | J Biol Chem2003，278，21： | 1 |
| 12 | Monitoring trace metal contaminants in green mussel, Perna viridis from the coastal waters of Karnataka, southwest coast of India 显示文摘 | Sasikumar G Krishnakumar P K Bhat G S | 2006 | Archives of Environmental Contamination and Toxicology2006，51，： | 1 |
| 13 | Effect of surfac treat mixing on partitioning of model hydrophobic drug, naproxen, between aqueous and micellar phases显示文摘 | Bhat P A Rather G M Dar A A | 2009 | J Plays Chem B2009，113，： | 1 |
| 14 | In vitro assessment of photocatalytic titanium oxide surface modified stainless steel orthodontic brackets for antiadherent and antibacterial properties againstLactobacillusacidophilus显示文摘 | Shah A G Shetty P C Ramachandra C S Bhat N S Laxmikanth S M | 2011 | Angle Orthod2011，81，： | 1 |
| 15 | Spring warming of the Eastern Arabian Sea and Bay of Bengal from buoy data显示文摘 | SENGUPTA D RAY P K BHAT G S | | 0，，15： | 1 |
| 16 | Aloe vera: Natures soothing healer to periodontal disease显示文摘 | Bhat G Kudva P Dodwad V | 2011 | Journal of Indian Soci- ety Periodontology2011，15，3： | 1 |
| 17 | Effect of Enzymatic Hydrolysis of Proteins on Reduction in Antigenicity (allergenicity) and Enhancement of Nutritional Quality of Milk显示文摘 | PUSHPA B P SHOBHA B BHAT G S | 2002 | The Ind J Nutr Dietet2002，，39： | 1 |
| 18 | Discovery of intense gamma-ray flashes of atmospheric origin显示文摘 | Fishman G J Bhat P N Mallozzi R | 1994 | Science1994，264，： | 1 |
| 19 | In vitro antimalarial activity of extracts of three plants used in the traditional medicine of India 显示文摘 | Bhat G P Surolia N | 2001 | Am J Trop Med Hyg2001，65，4： | 1 |
| 20 | A Comparative Study of Cell Death using Electrical Capacitance Measurements and Dielectrophoresis显示文摘 | Patel P M Bhat A Markx G H | 2008 | Enzyme and Microbial Technology2008，43，7： | 1 |
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