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| 1 | Expression of HER2 and bradykinin B_1 receptors in precursor lesions of gallbladder carcinoma显示文摘AIM:To determine the expression of HER2 and bradykinin B 1 receptors(B 1 R) in the two pathogenic models of gallbladder cancer:the metaplasia-dysplasia-carcinoma and the adenoma-carcinoma pathways.METHODS:Receptor proteins were visualized by immunohistochemistry on 5-μm sections of paraffin-embedded tissue.Expression of both receptors was studied in biopsy samples from 92 patients(6 males and 86 females;age ranging from 28 to 86 years,mean 56 years).High HER2 expression in specimens was additionally investigated by fluorescence in situ hybridiza-tion.Cell proliferation in each sample was assessed by using the Ki-67 proliferation marker.RESULTS:HER2 receptor protein was absent in adenomas and in normal gallbladder epithelium.On the contrary,there was intense staining for HER2 on the basolateral membrane of epithelial cells of intestinal metaplasia(22/24;91.7%) and carcinoma in situ(9/10;90%),the lesions that displayed a significantly high proliferation index.Protein up-regulation of HER2 in the epithelium with metaplasia or carcinoma in situ was not accompanied by HER2 gene amplification.A similar result was observed in invasive carcinomas(0/12).The B 1 R distribution pattern mirrored that of HER2 except that B 1 R was additionally observed in the adenomas.The B 1 R appeared either as cytoplasmic dots or labeling on the apical cell membrane of the cells composing the epithelia with intestinal metaplasia(24/24;100%) and carcinoma in situ(10/10;100%) and in the epithelial cells of adenomas.In contrast,both HER2(4/12;33%) and B 1 R(1/12;8.3%) showed a low expression in invasive gallbladder carcinomas.CONCLUSION:The up-regulation of HER2 and B1R in precursor lesions of gallbladder carcinoma suggests cross-talk between these two receptors that may be of importance in the modulation of cell proliferation in gallbladder carcinogenesis. | Cesar Toledo Carola E Matus Ximena Barraza Pamela Arroyo Pamela Ehrenfeld Carlos D Figueroa Kanti D Bhoola Maeva del Pozo Maria T Poblete | 2012 | World Journal of Gastroenterology2012，18，11： | 6 |
| 2 | Bioregulation of kinins:kallikreins,kininogens,and kininases显示文摘 | Bhoola K D Figueroa C D Worthy K | 1992 | Pharmacol Rev1992，44，1： | 1 |
| 3 | Expression of the tissue kallikrein-kinin cascade in granulosa ceils of the ovary 显示文摘 | Plendl J Snyman C Bhoola KD | 2002 | Biol Chem2002，383，12： | 1 |
| 4 | Immune responses in caneer显示文摘 | Adam JK Odhav B Bhoola KD | | 0，，01： | 1 |
| 5 | Diagnosis and management of epithelial o- varian cancer 显示文摘 | Bhoola S Hoskins WJ | 2006 | Obstet Gyneco12006，107，6： | 1 |
| 6 | Macrodactyly in the foot显示文摘 | DennysonWG Bear JN Bhoola KD | 1977 | J Bone Joint Surg2Br1977，59，： | 1 |
| 7 | Genealogy,expression,and cellular function of transforming growth factor-beta显示文摘 | Govinden R Bhoola KD | 2003 | Pharmacol Ther2003，98，2： | 1 |
| 8 | Experimental evalua- tion of collagen sponge as a dural graft显示文摘 | Narotam PK Van Dellen JR Bhoola K | 1993 | BrJ Neurosurg1993，7，6： | 1 |
| 9 | Kallikrein and kinin receptor genes显示文摘 | Mahabeer R Bhoola KD | 2000 | Pharmacol Ther2000，88，1： | 1 |
| 10 | Bioregulation of kinins:kallikreins, kininogens, and kininases 显示文摘 | Bhoola KD Figueroa CD Worthy K | 1992 | Pharmacol Rev1992，44，： | 1 |
| 11 | Natural products for cancer prevention: a global perspective显示文摘 | Reddy L Odhav B Bhoola K D | 2003 | Pharmacology & Therapeutics2003，99，1： | 1 |
| 12 | Genealogy expression,and cellular function of transforming growth factor-beta显示文摘 | GOVINDEN R BHOOLA K D | 2003 | Pharmacol Ther2003，98，2： | 1 |
| 13 | Modulating effects of fumonisin BI and ochratoxin A on leukocytes and mes- senger cytokines of the human immune system显示文摘 | Odhav B Adam J K Bhoola K D | 2008 | International Immunopharmacol2008，8，6： | 1 |
| 14 | Genealogy,expression,and cellular function of transforming growth factor-β显示文摘 | Govinden R Bhoola KD | 2003 | Pharmacology & Therapeutics2003，98，6： | 1 |
| 15 | The association of anticardiolipin antibodies with severe early-onset preeclampsia显示文摘 | Moodley J Bhoola V Duursma J | 1995 | S Afr Med J1995，85，： | 1 |
| 16 | Bioregulation of kinins: kallikreins, kininogens, and kininases显示文摘 | Bhoola K D Figueroa C D Worthy K | 1992 | Pharmacol Rev1992，44，1： | 1 |
| 17 | Genealogy, expression, and cellular function of transforming growth factor-J3 显示文摘 | Govinden R Bhoola K D | 2003 | Pharmacol Therapcut2003，98，： | 1 |
| 18 | Kallikrein and kinin receptor expression in inflammation and cancer显示文摘 | Bhoola K Ramsaroop R Plendl J | 2001 | Biol chem2001，382，1： | 1 |
| 19 | Bioregulation of kinins : kallikreins, kininogens, and kininases 显示文摘 | Bhoola KD Figueroa CD Worthy K | 1992 | Pharmacol Rev1992，44，2： | 1 |
| 20 | Genealogy,expression,and cellular function of transforming growth factor-beta显示文摘 | Govinden R Bhoola KD | 2003 | Pharmacol Ther2003，98，2： | 1 |
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