|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Treatment outcomes for multidrug-resistant tuberculosis under DOTS-Plus:a systematic review and meta-analysis of published studies显示文摘Background:Anti-tuberculosis drug resistance is a major public health problem that threatens the progress made in tuberculosis care and control worldwide.Treatment success rates of multidrug-resistant tuberculosis(MDR-TB)is a key issue that cannot be ignored.There is a paucity of evidence that assessed studies on the treatment of MDR-TB,which focus on the effectiveness of the directly observed treatment,short-course(DOTS)-Plus program.Therefore,it is crucial to assess and summarize the overall treatment outcomes for MDR-TB patients enrolled in the DOTS-Plus program in recent years.The purpose of this study was to thus assess and summarize the available evidence for MDR-TB treatment outcomes under DOTS-Plus.Methods:A systematic review and meta-analysis of published literature was conducted.Original studies were identified using the databases MEDLINE®/PubMed®,Hinari,and Google Scholar.Heterogeneity across studies was assessed using the Cochran’s Q test and I2 statistic.Pooled estimates of treatment outcomes were computed using the random effect model.Results:Based on the 14 observational studies included in the meta-analysis,it was determined that 5047 patients reported treatment outcomes.Of these,the pooled prevalence,63.5%(95%CI:58.4-68.5%)successfully completed full treatment(cured or treatment completed)with a pooled cure rate of 55.6%,whereas 12.6%(95%CI:9.0-16.2%)of the patients died,14.2%(95%CI:11.6-16.8%)defaulted from therapy,and 7.6%(95%CI:5.6-9.7%)failed therapy.Overall 35.4%(95%CI:30-40.8%)of patients had unsuccessful treatment outcomes.An unsatisfactorily high percentage 43%(95%CI:32-54%)of unsuccessful treatment outcomes was observed among patients who were enrolled in standardized treatment regimens.Conclusion:This study revealed that patients with MDR-TB exhibited a very low treatment success rate compared to the World Health Organization 2015 target of at least 75 to 90%.The high default rate observed by conducting this literature review could possibly explain the spread of the MDR-TB strain in various populations.A better treatment success rate was observed among patients in individualized treatment regimens than in standardized ones.Conducting further individual-based meta-analysis is recommended to identify potential factors for defaulting treatment using large-scale and multi-center studies. | Kelemu Tilahun Kibret Yonatan Moges Peter Memiah Sibhatu Biadgilign | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 2 | Mortality and associ-ated risk factors in a cohort of tuberculosis patients treated underDOTS programme in Addis Ababa,Ethiopia 显示文摘 | Getahun B Ameni G Biadgilign S | 2011 | BMC InfectDis2011，11，： | 1 |
| 3 | HIV-positive status disclosure among men and women receiving antiretroviral treatment in eastern Ethiopia显示文摘 | Reda AA Biadgilign S Deribe K et a/ | 2013 | AIDS Care2013，25，8： | 1 |
| 4 | Barriers and facilitators to antiretroviral medication adherence among HIV-infected paediatric patients in Ethiopia:A qualitative study显示文摘 | Biadgilign S Deribew A Amberbir A | | 0，，04： | 1 |
| 5 | Barriers and facilitatorsto antiretroviral medication adherence among HIV-infected paediatricpatients in Ethiopia:a qualitative study 显示文摘 | Biadgilign S Deribew A Amberbir A | 2009 | SAHARA J2009，6，4： | 1 |
| 6 | Mortality and associated risk factors in a cohort of tuberculosis patients treated under DOTS programme in Addis Ababa,Etheopia显示文摘 | Getahun B Ameni G Biadgilign S | 2011 | BMC infectious disease2011，11，： | 1 |
| 7 | Male involvement in family planning pro- gram in northern ethiopia: An application of the transtheoretical model 显示文摘 | Berhane A Biadgilign S Memiah P | 2015 | Pa- tient Educ Courts2015，98，4： | 1 |
| 8 | Experience of stigma and discrimination and the implications for healthcare seeking behavior among people living with HIV/AIDS in resource-limited setting显示文摘 | Alemu T Biadgilign S Deribe K | 2013 | SAHARA J2013，10，1： | 1 |
| 9 | Adherence to highly ac- tive antiretroviral therapy and its correlates among H1V infected pe- diatric patients in Ethiopia显示文摘 | Biadgilign S Deribew A Amberbir A | 2008 | BMC Pediatrics2008，8，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员