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| 1 | Smoothelin,a new marker to determine the origin of liver fibrogenic cells显示文摘AIM:To explore this hypothesis that smooth muscle cells may be capable of acquiring a myofibroblastic phenotype,we have studied the expression of smoothelin in fibrotic conditions.METHODS:Normal liver tissue(n=3)was obtained from macroscopically normal parts of hepatectomy,taken at a distance from hemangiomas.Pathological specimens included post-burn cutaneous hypertrophic scars(n=3),fibrotic liver tissue(n=5),cirrhotic tissue(viral and alcoholic hepatitis)(n=5),and hepatocellular carcinomas(n=5).Tissue samples were fixed in 10%formalin and embedded in paraffin for immunohistochemistry or were immediately frozen in liquid nitrogen-cooled isopentane for confocal microscopy analysis.Sections were stained with antibodies against smoothelin,which is expressed exclusively by smooth muscle cells,andα-smooth muscle actin,which is expressed by both smooth muscle cells and myofibroblasts.RESULTS:In hypertrophic scars,α-smooth muscle actin was detected in vascular smooth muscle cells and in numerous myofibroblasts present in and around nodules,whereas smoothelin was exclusively expressed in vascular smooth muscle cells.In the normal liver,vascular smooth muscle cells were the only cells that expressα-smooth muscle actin and smoothelin.In fibrotic areas of the liver,myofibroblasts expressingα-smooth muscle actin were detected.Myofibroblasts co-expressingα-smooth muscle actin and smoothelin were observed,and their number was slightly increased in parallel with the degree of fibrosis(absent in liver with mild or moderate fibrosis;5%to 10%positive in liver showing severe fibrosis).In cirrhotic septa,numerous myofibroblasts co-expressedα-smooth muscle actin and smoothelin(more than 50%).In hepatocellular carcinomas,the same pattern of expression forα-smooth muscle actin and smoothelin was observed in the stroma reaction surrounding the tumor and around tumoral cell plates.In all pathological liver samples,α-smooth muscle actin and smoothelin were co-expressed in vascular smooth muscle cells.CONCLUSION:During development of advanced liver fibrosis,a subpopulation of myofibroblasts expressing smoothelin may be derived from vascular smooth muscle cells,illustrating the different cellular origins of myofibroblasts. | Sébastien Lepreux Christelle Guyot Fabrice Billet Chantal Combe Charles Balabaud Paulette Bioulac-Sage Alexis Desmoulière | 2013 | World Journal of Gastroenterology2013，19，48： | 2 |
| 2 | Adapative control of flexural waves propagating in a beam 显示文摘 | Elliott S J Billet L | 1993 | Journal of Sound and Vibration:1993，163，2： | 1 |
| 3 | Tetrachlorodibenzodioxin isomer differentiation by micro diffuse reflectance fourier transform infrared spectrometry at the low nanogram level显示文摘 | Gurka D F Billets S Brasch J W | 1985 | Anal Chem1985，57，9： | 1 |
| 4 | The theologies of transparency in Europe: The limits and possibilities of 'fusion' in the EU transparency regime 显示文摘 | Billet S | 2007 | Public Affairs2007，7，4： | 1 |
| 5 | Interleukin-1B-mediated induction of COX-2 in the CNS contribution to inflammatory pain hypersensitivity显示文摘 | Samad TA Moore KA Sapirstein A Billet S Allchorne A Poole S | 2001 | Nature2001，410，： | 1 |
| 6 | Role of nuclear factor-kappa B activation in the adverse effects induced by air pollution particulate matter ( PMz 5 ) in human epithelial lung cells (L132) in culture 显示文摘 | Dagher Z Garcon G Billet S | 2007 | J Appl Toxieol2007，27，3： | 1 |
| 7 | A review of the export of carbon in river water: fluxes and processes 显示文摘 | Hope D Billet M F Cresser M S | 1994 | Environmental Pollution1994，84，： | 1 |
| 8 | Experimental design considerations for verifying the performance of screening technologies for dioxin and dioxin-like compounds in soils and sediments显示文摘 | DINDAL A BILLETS S | 2008 | Chemcophere2008，，： | 1 |
| 9 | Thermodynamic effects on developed cavitation显示文摘 | Holl J W Billet M L Weir D S | 1975 | Journal of Fluids Engineering1975，97，4： | 1 |
| 10 | Role of angiotensin II AT1 receptor activation in cardiovascular diseases 显示文摘 | Billet S | 2008 | Kidney Int2008，74，11： | 1 |
| 11 | A review of the export of carbon in river water:fluxes and processes显示文摘 | Hope D Billet M F Cresser M S | 1994 | Environmental Pollution1994，84，： | 1 |
| 12 | Neurologic complications of cardiac surgery and interventional cardiology 显示文摘 | Hocker S Wijdicks EF Billet J | 2014 | Handb Clin N eurol2014，119，： | 1 |
| 13 | The lower trapexins islandmyocutaneous flap显示文摘 | Baek S Billet HF Drespi YP | 1980 | Ann Plas! Surg1980，5，2： | 1 |
| 14 | A review of the export of carbon in river water: fluxes and processes 显示文摘 | Hope D Billet M F Cresser M S | 1994 | Environmental Pollution1994，84，3： | 1 |
| 15 | Role of angiotensin 11 AT1 receptor activation in cardiovascular diseases显示文摘 | Billet S Aguilar F Baudry C | 2008 | Kidney Int2008，74，11： | 1 |
| 16 | Experience multiple loss of persons with AIDS: Grief and bBereavement issues显示文摘 | Billet R Rice S | 1990 | Health and Social Work1990，1，： | 1 |
| 17 | Sequential improvements in organ procurement increase the organ donation rate显示文摘 | Billeter A T Sklare S Franklin G A | 2012 | Injury2012，43，11： | 1 |
| 18 | Experimental infection by capillary tube feeding of Rhipicephalus san- guineus with Bartonella vinsonii subspecies berkhoffi 显示文摘 | Billeter S A Kasten R W Killmaster L F | 2012 | Comp Immunol Microbiol Infec Dis2012，，： | 1 |
| 19 | Role of angiotenain Ⅱ AT1 receptor activation in cardiovascular diseases显示文摘 | Billet S Aguilar F | 2008 | Kidney Int2008，74，11： | 1 |
| 20 | Adaptive control of flexural waves propagating in a beam显示文摘 | Elliot S J Billet L | 1993 | Journal of Sound and Vibration1993，163，2： | 1 |
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