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| 1 | PI 3-kinase pathway is responsible for antiapoptotic effects of atrial natriuretic peptide in rat liver transplantation显示文摘AIM:To investigate the in vivo effect of atrial natriureticpeptide(ANP)and its signaling pathway during ortho-topic rat liver transplantation.METHODS:Rats were infused with NaCl,ANP(5 μg/kg),wortmannin(WM,16 μg/kg),or a combination ofboth for 20 min.Livers were stored in UW solution(4°C)for 24 h,transplanted and reperfused.Apoptosis wasexamined by caspase-3 activity and TUNEL staining.Phosphorylation of Akt and Bad was visualized by West-ern blotting and phospho-Akt-localization by confocalmicroscopy.RESULTS:ANP-pretreatment decreased caspase-3activity and TUNEL-positive cells after cold ischemia,indicating antiapoptotic effects of ANP in vivo.The an-tiapoptotic signaling of ANP was most likely caused byphosphorylation of Akt and Bad,since pretreatment withPI 3-kinase inhibitor WM abrogated the ANP-inducedreduction of caspase-3 activity.Interestingly,analysis ofliver tissue by confocal microscopy showed translocationof phosphorylated Akt to the plasma membrane of hepa-tocytes evoked by ANP.CONCLUSION:ANP activates the PI-3-kinase pathwayin the liver in vivo leading to phosphorylation of Bad, an event triggering antiapoptotic signaling cascade inischemic liver. | Uwe Grutzner Melanie Keller Michael Bach Alexandra K Kiemer Herbert Meissner Manfred Bilzer Stefan Zahler Alexander L Gerbes Angelika M Vollmar | 2006 | World Journal of Gastroenterology2006，12，7： | 3 |
| 2 | Evaluation of serum Cystatin C concentration as a marker of renal function in patients with cirrhosis of the liver显示文摘 | Gerbes AL Gulberg V Bilzer M | | 0，，： | 1 |
| 3 | Glutathione protects the rat liver against reperfusion injury after hypothermic preservation显示文摘 | Bilzer M Paumgartner G Gerbes A L | 1999 | Gastroenterol1999，117，： | 1 |
| 4 | Evaluation of serum cystatin C concentration as a marker of renal function in patients with cirrhosis of the liver显示文摘 | Gerbes A L Gulberg V Bilzer M | 2002 | Gut2002，50，1： | 1 |
| 5 | Role of Kupffer cells in host defense and liver disease 显示文摘 | Bilzer M Roggel F Gerbes AL | 2006 | Liver Int2006，26，10： | 1 |
| 6 | Glutathione treatment protectsthe rat liver against injury after warm ischemia and Kupffercell activation显示文摘 | Bilzer M Baron A Schauer R | 2002 | Digestion2002，66，1： | 1 |
| 7 | Long-term therapy and retreatment of hepatorenal syndrome type I with ornipressin and opamine显示文摘 | Gulberg V Bilzer M C erbes AL | 1999 | Hepatology1999，30，4： | 1 |
| 8 | Role of Kupffer cells in host defense and liver disease显示文摘 | Bilzer M Roggel F Gerbes A L | | 0，，10： | 1 |
| 9 | Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver显示文摘 | Beuers U Bilzer M Chittattu A | 2001 | Hepatology2001，33，5： | 1 |
| 10 | Evaluation of serum cystatin C coneentration as a marker of rnal function inpatients with cirrhosis of the oiver显示文摘 | Gerbes AL Gulberg V Bilzer M | 2002 | Gut2002，50，50： | 1 |
| 11 | Role of Kupffer cells in host defense and liver disease 显示文摘 | Bilzer M Roggel F Gerbes AL | 2006 | Liver Int2006，26，10： | 1 |
| 12 | Transjugular intrahepatic portosystemic shunt for cirrhosis and ascites: Effects in patients with organic or functional renal failure显示文摘 | Michl P Gulberg V Bilzer M | 2000 | Scand J Gastroenterol2000，35，6： | 1 |
| 13 | Long-termtherapy and reteratment of hepatorenal syndrome type Ⅰ with ornipressin and dopamine显示文摘 | GULBERG V BILZER M GERBESAL | 1999 | Hepatology1999，30，4： | 1 |
| 14 | Improved quality of life in patients with refractory or recidivant ascites after insertion of transjugular intrahepatic portosystemic shunts显示文摘 | Gulberg V Liss I Bilzer M | 2002 | Digestion2002，66，2： | 1 |
| 15 | Kupffer cell acttivation by hydro- gen peroxide: a new mechanism of portal pressure increase 显示文摘 | Steib C J Bilzer M Htirtl JM | 2010 | Shock2010，33，4： | 1 |
| 16 | Kupffer cell activation by hydrogen peroxide: a new mechanism of portal pressure increase 显示文摘 | Steib C J Bilzer M Htirtl JM | 2010 | Shock2010，33，4： | 1 |
| 17 | Treatment tdth the leukotriene inhibitor montelukast for 10 days tttenuates portal hypertension in rat liver cirrhosis 显示文摘 | Steib C J Bilzer M op den Winkel M | 2010 | Hepatology2010，51，6： | 1 |
| 18 | Glutathione treat- ment protects the rat liver against injury after warm is- chemia and Kupffer cell activation显示文摘 | Bilzer M Baron A Schauer R | 2002 | Digestion2002，66，1： | 1 |
| 19 | Evaluation of serum cystatin C concentration as a marker of renal function in patients with cirrhosis of the liver显示文摘 | Gerbes AL Gtilberg V Bilzer M | 2002 | Gut2002，，50： | 1 |
| 20 | Preservation injury of the liver:mecha- nisms and novel therapeutic strategies显示文摘 | Bilzer M Gerbes AL | 2000 | J Hepatol2000，32，3： | 1 |
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