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| 1 | The role of general anesthetics and the mechanisms of hippocampal and extra-hippocampal dysfunctions in the genesis of postoperative cognitive dysfunction显示文摘Postoperative cognitive dysfunction(POCD) is a multifactorial process with a huge number of predisposing, causal, and precipitating factors. In this scenario, the neuroinflammation and the microglial activation play a pivotal role by triggering and amplifying a complex cascade involving the immuno-hormonal activation, the micro circle alterations, the hippocampal oxidative stress activation and, finally, an increased blood-brain barrier's permeability. While the role of anesthetics in the POCD's genesis in humans is debated, a huge number of preclinical studies have been conducted on the topic and many mechanisms have been proposed to explain the potential neurodegenerative effects of general anesthetics. Probably, the problem concerns on what we are searching for and how we are searching and, surprisingly, preclinical studies showed that anesthetics may also manifest neuroprotective properties. The aim of this paper is to offer an overview on the potential impact of general anesthetics on POCD. Mechanisms of hippocampal and extra-hippocampal dysfunction due to neuroinflammation are discussed, whereas further research perspectives are also given. | Marco Cascella Sabrina Bimonte | 2017 | Neural Regeneration Research2017，12，11： | 15 |
| 2 | Towards a better understanding of anesthesia emergence mechanisms: Research and clinical implications显示文摘Emergence from anesthesia(AE) is the ending stage of anesthesia featuring the transition from unconsciousness to complete wakefulness and recovery of consciousness(RoC). A wide range of undesirable complications, including coughing, respiratory/cardiovascular events, and mental status changes such as emergence delirium, and delayed RoC, may occur during this critical phase. In general anesthesia processes, induction and AE represent a neurobiological example of 'hysteresis'. Indeed, AE mechanisms should not be simply considered as reverse events of those occurring in the induction phase. Anesthesia-induced loss of consciousness(LoC) and AE until RoC are quite distinct phenomena with, in part, a distinct neurobiology. Althoughanaesthetics produce LoC mostly by affecting cortical connectivity, arousal processes at the end of anesthesia are triggered by structures deep in the brain, rather than being induced within the neocortex. This work aimed to provide an overview on AE processes research, in terms of mechanisms, and EEG findings. Because most of the research in this field concerns preclinical investigations, translational suggestions and research perspectives are proposed. However, little is known about the relationship between AE neurobiology, and potential complications occurring during the emergence, and after the RoC. Thus, another scope of this review is to underline why a better understanding of AE mechanisms could have significant clinical implications, such as improving the patients' quality of recovery, and avoiding early and late postoperative complications. | Marco Cascella Sabrina Bimonte Maria Rosaria Muzio | 2018 | World Journal of Methodology2018，8，2： | 6 |
| 3 | 火力发电厂电子监控技术显示文摘电厂远程监控和诊断是提高效率、降低成本、延长设备寿命、在行业竞争中保持优势的有效方法。结合法国燃煤电厂的实践,详细介绍了电厂电子监控系统的组成、功能和应用情况。 | Gerard Bimont | 2008 | 华东电力2008，36，2： | 2 |
| 4 | Age-related deficits as working memory load increases: relationships with growth factors显示文摘 | Bimonte HA Nelson ME Granholm AC | 2003 | Neurobiology of Aging2003，24，1： | 2 |
| 5 | Spatial ()nline Analytical Processing of Geographic Data through the Google Earth Interface显示文摘 | Martin() S D Bimonte S Bertolotto M | 2011 | Geoeomputation Sustainability and Envi- ronmental Planning2011，348，： | 1 |
| 6 | Tourism,residents'attitudes and perceived carrying capacity with an experimental study in five Tuscan destinations显示文摘 | Bimonte S Punzo L F | 2011 | International Journal of Sustainable Development2011，14，3： | 1 |
| 7 | Happiness and nature-based vacations显示文摘 | Bimonte S Faralla V | 2014 | Annals of Tourism Research2014，46，： | 1 |
| 8 | Effects of a saturated fat and high cholesterol diet on memoryand hippocampal morphology in the middle - aged rat 显示文摘 | GRANHOLM A C BIMONTE NELSON H A MOORE A B etal | 2008 | JAlzheimers Dis2008，14，2： | 1 |
| 9 | Tourism, residents' attitudes and perceived carrying capacity with an experimental study in five tuscan destinations 显示文摘 | Bimonte Salvatore Punzo Lionello F | 2011 | International Journal of Sustainable Development2011，14，3： | 1 |
| 10 | Ofdl is required in limb bud patterning and endochondral bone development 显示文摘 | Bimonte S De Angelis A Quagliata L | 2011 | Dev Biol2011，349，2： | 1 |
| 11 | Curcumin Inhibits Tumor Growth and Angiogenesis in an Orthotopic Mouse Model of Human Pancreatic Cancer显示文摘 | Bimonte S Barbieri A Palma G | 2013 | BioMed Research International2013，2013，： | 1 |
| 12 | The“tragedyoftourismresources”astheoutcomeofastrategicgame:Anewanalyticalframework显示文摘 | BimonteS | 2008 | EcologicalEconomics2008，67，3： | 1 |
| 13 | Information Access, Income Distribution, and the Environmental Kuznets Curve显示文摘 | Bimonte S | 2002 | Ecological Economic2002，41，1： | 1 |
| 14 | Advantages and issues of concern regarding approaches to peripheral nerve block for total hip arthroplasty显示文摘In older patients with comorbidities,hip fractures are both an important and debilitating condition.Since multimodal and multidisciplinary perioperative strategies can hasten functional recovery after surgery improving clinical outcomes,the choice of the most effective and safest pathway represents a great challenge.A key point of concern is the anesthetic approach and above all the choice of the locoregional anesthesia combined with general or neuraxial anesthesia. | Marco Crisci Arturo Cuomo Cira Antonietta Forte Sabrina Bimonte Gennaro Esposito Maura C Tracey Marco Cascella | 2021 | World Journal of Clinical Cases2021，9，36： | 1 |
| 15 | Interleukin 18: friend or foe in cancer 显示文摘 | Palma G Barbieri A Bimonte S | 2013 | Biochim Biophys Acta2013，1836，2： | 1 |
| 16 | Information Access, Income Distribution, and the Environmental Kuznets Curve 显示文摘 | Bimonte | 2002 | Ecological Economics2002，，41： | 1 |
| 17 | Information access,income distri- bution,and the Environmental Kuznets Curve显示文摘 | Salbatore Bimonte | 2002 | Ec- ological Economics2002，41，： | 1 |
| 18 | Information Access, Income Distribution, and the Environmental Kuznets Curve 显示文摘 | BIMONTE S | 2002 | Ecological Economics2002，41，1： | 1 |
| 19 | Age-related deficits as working memory load increase: relationships with growth factors 显示文摘 | Bimonte HA Nelson ME Granholm AC | 2003 | Neurobiolaging2003，24，1： | 1 |
| 20 | Information Access, Income Distribution, and the Environmental Kuznets Curve 显示文摘 | Bimonte S | 2002 | Ecological Economics2002，41，1： | 1 |
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