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| 1 | An-2 Encodes a Cytokinin Synthesis Enzyme that Regulates Awn Length and Grain Production in Rice显示文摘大量词法、生理的特点在驯服下面在栽培米饭 Oryza sativa 和野米饭 Oryza rufipogon 之间变化了。这里,我们报导 An-2 基因克隆,编码象蛋白质 6 一样的孤独的盖伊(OsLOGL6 ) ,它在 O 催化细胞激动素合成的最后的步。rufipogon。在 theawnless indica Guangluai 4 的基因背景怀有 An-2 的野等位基因的 near-isogenic 线证明 An-2 由由每植物每圆锥花序和 tillers 减少谷物提高房间分割,而是减少谷物生产支持芒延伸。我们表明在 An-2 地点的一个基因变化在减少芒长度并且在驯养的米饭增加 tiller 和谷物数字上有大影响。基因 expressionpatterns 的分析建议 An-1 调整芒的形成初发,并且 An-2 支持芒延伸。在栽培米饭的 theAn-2 地点的核苷酸差异被发现显著地与野米饭的相比被减少,建议 An-2 地点受到人工的选择。我们因此在 An-2 的基因变化的选择由于减少的芒长度并且增加的 proposethat 在栽培米饭的谷物产量。 | Benguo Gu Taoying Zhou Jianghong Luo Hui Liu Yongchun Wang Yingying Shangguan Jingjie Zhu Yan Li Tao Sang Zixuan Wang Bin Han | 2015 | Molecular Plant2015，8，11： | 22 |
| 2 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 3 | Generation of a monkey with MECP2 mutations by TALEN-based gene targeting显示文摘Gene editing in model organisms has provided critical insights into brain development and diseases. Here, we report the generation of a cynomolgus monkey(Macaca fascicularis) carrying MECP2 mutations using transcription activator-like effector nucleases(TALENs)-mediated gene targeting. After injecting TALENs mRNA into monkey zygotes achieved by in vitro fertilization and embryo transplantation into surrogate monkeys, we obtained one male newborn monkey with an MECP2 deletion caused by frameshifting mutation in various tissues. The monkey carrying the MECP2 mutation failed to survive after birth, due to either the toxicity of TALENs or the critical requirement of MECP2 for neural development. The level of MeCP2 protein was essentially depleted in the monkey's brain. This study demonstrates the feasibility of introducing genetic mutations in non-human primates by site-specific gene-editing methods. | Zhen Liu Xue Zhou Ying Zhu Zhi-Fang Chen Bin Yu Yan Wang Chen-Chen Zhang Yan-Hong Nie Xiao Sang Yi-Jun Cai Yue-Fang Zhang Chen Zhang Wen-Hao Zhou Qiang Sun Zilong Qiu | 2014 | Neuroscience Bulletin2014，30，3： | 17 |
| 4 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 5 | Intraportal mesenchymal stem cell transplantation prevents acute liver failure through promoting cell proliferation and inhibiting apoptosis显示文摘BACKGROUND: Transplantation of mesenchymal stem cells(MSCs) has been regarded as a potential treatment for acute liver failure(ALF), but the optimal route was unknown. The present study aimed to explore the most effective MSCs transplantation route in a swine ALF model.METHODS: The swine ALF model induced by intravenous injection of D-Gal was treated by the transplantation of swine MSCs through four routes including intraportal injection(In P group), hepatic intra-arterial injection(AH group), peripheral intravenous injection(PV group) and intrahepatic injection(IH group). The living conditions and survival time were recorded. Blood samples before and after MSCs transplantation were collected for the analysis of hepatic function. The histology of liver injury was interpreted and scored in terminal samples. Hepatic apoptosis was detected by TUNEL assay. Apoptosis and proliferation related protein expressions including cleaved caspase-3, survivin, AKT, phospho-AKT(Ser473), ERK and phospho-ERK(Tyr204) were analyzed by Western blotting.RESULTS: The average survival time of each group was 10.7 ±1.6 days(In P), 6.0±0.9 days(AH), 4.7±1.4 days(PV), 4.3±0.8 days(IH), respectively, when compared with the average survival time of 3.8±0.8 days in the D-Gal group. The survival rates between the In P group and D-Gal group revealed a statistically significant difference(P<0.01). Pathological and biochemical analysis showed that liver damage was the worst in the D-Gal group, while less injury in the In P group. Histopathological scores revealed a significant decrease in the In P group(3.17±1.04, P<0.01) and AH group(8.17±0.76, P<0.05) as compared with that in the D-Gal group(11.50±1.32). The apoptosis rate in the In P group(25.0%±3.4%, P<0.01) and AH group(40.5%±1.0%, P<0.05) was lower than that in the D-Gal group(70.6%±8.5%). The expression of active caspase-3 was inhibited, while the expression of survivin, AKT, phosphoAKT(Ser473), ERK and phospho-ERK(Tyr204) was elevated in the In P group.CONCLUSIONS: Intraportal injection was superior to other pathways for MSC transplantation. Intraportal MSC transplantation could improve liver function, inhibit apoptosis and prolong the survival time of swine with ALF. The transplanted MSCs may participate in liver regeneration via promoting cell proliferation and suppressing apoptosis during the initial stage of ALF. | Jian-Feng Sang Xiao-Lei Shi Bin Han Tao Huang Xu Huang Hao-Zhen Ren Yi-Tao Ding | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，6： | 9 |
| 6 | A Pyramid Breeding of Eight Grain-yield Related Quantitative Trait Loci Based on Marker-assistant and Phenotype Selection in Rice(Oryza sativa L.)显示文摘1000 谷物重量和小穗状花小穗数字每圆锥花序是为米饭谷物产量的二个重要部件。在我们的以前的学习,每圆锥花序和 1000 谷物重量授与小穗状花小穗数字的八量的特点 loci (QTL ) 通过 150 米饭 recombinant 的基于顺序的 genotyping 被印射生来的线(RIL ) 。在这研究,我们用染色体片断替换线(CSSL ) 从 Nipponbare 验证了四 QTL 的效果,并且节节上升八谷物收益联系了 QTL。与积极效果包含八 QTL 的新线作为与父母变化 93-11 相比显示出增加的圆锥花序和小穗状花小穗尺寸。我们进一步建议了基于标记助手和显型选择(地图) 引起计划的一座新奇金字塔。没有巨大的生气工作,这个计划允许在单个杂交象 24 QTL 一样同样多节节上升。这研究提供了卓见进 high-yielding 米饭繁殖的直接财富的米饭谷物产量的分子的基础。 | Guo Zong Ahong Wang Lu Wang Guohua Liang Minghong Gu Tao Sang Bin Han | 2012 | Journal of Genetics and Genomics2012，39，7： | 9 |
| 7 | Timing of upper gastrointestinal endoscopy does not influence short-term outcomes in patients with acute variceal bleeding显示文摘AIM To examine the association between the timing of endoscopy and the short-term outcomes of acute variceal bleeding in cirrhotic patients.METHODS This retrospective study included 274 consecutive patients admitted with acute esophageal variceal bleeding of two tertiary hospitals in Korea. We adjusted confounding factors using the Cox proportional hazards model and the inverse probability weighting(IPW) method. The primary outcome was the mortality of patients within 6 wk.RESULTS A total of 173 patients received urgent endoscopy(i.e., ≤ 12 h after admission), and 101 patients received nonurgent endoscopy(> 12 h after admission). The 6-wk mortality rate was 22.5% in the urgent endoscopy group and 29.7% in the non-urgent endoscopy group, and there was no significant difference between the two groups before(P = 0.266) and after IPW(P = 0.639). The length of hospital stay was statistically different between the urgent group and non-urgent group(P = 0.033); however, there was no significant difference in the inhospital mortality rate between the two groups(8.1% vs 7.9%, P = 0.960). In multivariate analyses, timing of endoscopy was not associated with 6-wk mortality(hazard ratio, 1.297; 95% confidence interval, 0.806-2.089; P = 0.284).CONCLUSION In cirrhotic patients with acute variceal bleeding, the timing of endoscopy may be independent of short-term mortality. | Jeong-Ju Yoo Young Chang Eun Ju Cho Ji Eun Moon Sang Gyune Kim Young Seok Kim Yun Bin Lee Jeong-Hoon Lee Su Jong Yu Yoon Jun Kim Jung-Hwan Yoon | 2018 | World Journal of Gastroenterology2018，24，44： | 8 |
| 8 | Studies on wind environment around high buildings in urban areas显示文摘High buildings or architectural complex in urban areas remarkably distort the urban surface wind fields. As the air flow approaches,local strong wind may appear around the buildings. The strong wind makes the pedestrians on sidewalks, entrances and terrace very uncomfortable and causes the pedestrian level wind environment problem. In this studies, hot-wire wind measurement, wind scouring in wind tunnel and numerical computation were carried out to evaluate the wind environment of tall buildings in the prevailing flow conditions in Beijing areas. The results obtained by three techniques were compared and mutually verified. The conclusions drawn from three approaches agree with each other. Also the advantages and limitations of each method were analyzed. It is suggested that the combination of different techniques may produce better assessment of wind environment around high buildings. | LIU Huizhi, JIANG Yujun, LIANG Bin, ZHU Fengrong, ZHANG Boyin & SANG Jianguo LAPC, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China Department of Atmospheric Sciences, School of Physics, Peking University, Beijing 1000871, China State Key Laboratory of Turbulence and Complex System, Peking University, Beijing 1000871, China | 2005 | Science China Earth Sciences2005，48，z2： | 5 |
| 9 | Pattern of instent neointimal formation compared to native atherosclerosis in the coronary bifurcation lesions: volumetric intravascular ultrasound analysis显示文摘 | XU Jian-qiang Young Bin Song Joo-Yong Hahn Seung-Hyuk Choi Jin-Ho Choi LU Cheng-zhi Sang Hoon Lee Kyung Pyo Hong Jeung Euy Park Hyeon-Cheol Gwon | 2013 | Chinese Medical Journal2013，，18： | 3 |
| 10 | DFOS Applications to Geo-Engineering Monitoring显示文摘Optical fiber sensing technology has developed rapidly since the 1980s with the development of the optical fiber and fiber optical communication technology.It is a new type of sensing technology that uses light as a carrier and optical fiber as a medium to sense and transmit external signals(measurands).Distributed fiber optical sensors(DFOS)can continuously measure the external physical parameters distributed along the geometric path of the optical fiber.Meanwhile,the spatial distribution and change information of the measured physical parameters over time can be obtained.This technology has unmatched advantages over traditional point-wise and electrical measurement monitoring technologies.This paper summarizes the state-of-the-art research of the application of the distributed optical fiber sensing tech no logy in geo-engineering in the past 10 years,mainly including the advantages of DFOS,the challenges in geo-engineering monitoring,related fundamental theoretical issues,sensing performance of the optical sensing cables,distributed optical fiber monitoring system for geo-engineering,and applications of optical fiber sensing technology in geo-engineering. | Bin SHI Dan ZHANG Honghu ZHU Chengcheng ZHANG Kai GU Hongwei SANG Heming HAN Mengya SUN Jie LIU | 2021 | Photonic Sensors2021，11，2： | 3 |
| 11 | Population genetics and evolutionary history of Miscanthus species in China显示文摘Miscanthus species have received considerable attention as a potential biomass source for renewable energy production because of their ability to produce high yields of biomass and adapt to a wide range of climates and soils. To explore the genetic diversity and phylogenetic relationship of Miscanthus species in China, we used 24 simple sequence repeat markers to genotype 100 natural populations representing all four Chinese Miscanthus species (M. sinensis Andersson, M. floridulus (Lab.) Warb. ex K. Schum.& Lauterb., M. sacchariflorus (Maxim.) Hack., and M. lutarioriparius L. Liu ex Renvoize & S. L. Chen). Based on phylogenetic, principal coordinate, and STRUCTURE analyses, we found that the 100 populations formed two major groups corresponding to sect. Triarrhena and sect. Miscanthus. Group 1 (i.e., sect. Triarrhena) was further subdivided into two subgroups corresponding to M. sacchariflorus and M. lutarioriparius;Group 2 (i.e., sect. Miscanthus) was subdivided into three subgroups, group 2a (M. sinensis populations in southern China), group 2b (M. sinensis populations in northern China), and group 2c (all the M. floridulus populations). Population genetics analyses indicated high levels of the genetic diversity at both population (HE = 0.468–0.599) and species (HE = 0.559–0.708) levels, indicative of the potential of these wild resources in future breeding programs. The species distribution modeling showed that M. sacchariflorus and M. lutarioriparius have experienced population reductions during the last glacial maximum and population expansion afterward;in contrast, M. sinensis and M. floridulus both underwent gradual population expansions from the last interglaciation to the present. We also suggest that M. floridulus originated from M. sinensis in southeast China through ecological speciation. The understanding of the evolutionary history and population dynamics of these species not only provides valuable information for further genetic improvement and breeding of this energy crop but also gives important insights into the origin and speciation processes of the Miscanthus species. | Shan-Shan Li Hai-Fei Zhou Wen-Li Chen Juan Yan Zhe Cai Ruo-Xun Wei Chih-Hui Chen Bin Han Jian-Qiang Li Tao Sang Song Ge | 2019 | Journal of Systematics and Evolution2019，57，5： | 2 |
| 12 | Comparison of litterfall production in three forest types in Jeju Island, South Korea显示文摘Litterfall, which is influenced by physical and biological factors, is a major pathway for carbon and nutrient cycling in forest ecosystems. The purpose of this study was to investigate monthly litterfall production in three forests in Jeju Island differentiated by forest composition and precipitation: Cheongsu(Quercus glauca as the dominant species;low precipitation), Seonheulb(Q. glauca as the dominant species;high precipitation), and Seonheulm(Q. glauca and Pinus thunbergii as the dominant species;high precipitation). Litterfall was collected monthly from April to December 2015 and divided into leaf litter, twig, bark, seeds, and unidentified materials.Seasonal patterns of litterfall production varied across stands according to their species composition. However,the amount of leaf litterfall and total litterfall were comparable among stands, ranging from 362 to 375 g m-2 for leaf litter and 524 g m-2 to 580 g m-2 for total litterfall.Oak leaf litter in May was the highest in all stands, while needle litter was the highest in December in Seonheulm.High twig litterfall in July may be attributable to high rainfall with strong winds and storms during the rainy season. Although forest type and climate factor had no influence on litterfall amounts in this study, the pattern of litterfall production was species dependent, suggesting diverse effects on carbon and nutrient cycling in these forests. | Ji Young An Si Ho Han Woo Bin Youn Sang Ick Lee Afroja Rahman Huong Thi Thuy Dao Jeong Min Seo Aung Aung Hyung-Soon Choi Hwa Ja Hyun Byung Bae Park | 2020 | Journal of Forestry Research2020，31，3： | 2 |
| 13 | High-efficiency green micro-LEDs with GaN tunnel junctions grown hybrid by PA-MBE and MOCVD显示文摘We fabricated p-i-n tunnel junction(TJ)contacts for hole injection on c-plane green micro-light-emitting diodes(micro-LEDs)by a hybrid growth approach using plasma-assisted molecular beam epitaxy(PA-MBE)and metal–organic chemical vapor deposition(MOCVD).The TJ was formed by an MBE-grown ultra-thin unintentionally doped In Ga N polarization layer and an n^(++)∕n^(+)-GaN layer on the activated p^(++)-Ga N layer prepared by MOCVD.This hybrid growth approach allowed for the realization of a steep doping interface and ultrathin depletion width for efficient inter-band tunneling.Compared to standard micro-LEDs,the TJ micro-LEDs showed a reduced device resistance,enhanced electroluminescence intensity,and a reduced efficiency droop.The size-independent J-V characteristics indicate that TJ could serve as an excellent current spreading layer.All these results demonstrated that hybrid TJ contacts contributed to the realization of high-performance micro-LEDs with long emission wavelengths. | YAOZHENG WU BIN LIU FEIFAN XU YIMENG SANG TAO TAO ZILI XIE KE WANG XIANGQIAN XIU PENG CHEN DUNJUN CHEN HAI LU RONG ZHANG YOUDOU ZHENG | 2021 | Photonics Research2021，9，9： | 2 |
| 14 | Application of the health risk assessment of acetochlor in the development of water quality criteria显示文摘Acetochlor is a widely used herbicide in agricultural production. Studies have shown that acetochlor has obvious environmental hormone effects, and long-term exposure may pose a threat to human health. To quantify the hazards of acetochlor in drinking water, a health risk assessment of acetochlor was conducted in major cities of China based on the data of acetochlor residue concentrations in drinking water. The approach of the Species Sensitivity Distributions(SSD) method is used to extrapolate from animal testing data to reflect worst case human toxicity. Results show that hazard quotients related to acetochlor residues in drinking water for different age groups range from 1.94 × 10-4 to 6.13 × 10-4, so, there are no indication of human risk. Compared to the total estimated hazard quotient from oral intake of acetochlor, the chronic exposure imputed to acetochlor residues in drinking water in China accounts for 0.4%. This paper recommends 0.02 mg/L to be the maximum acetochlor residue concentration level in drinking water and source water criteria. | Wei An Chenhui Sang Kristian Marienlund Jensen Peter Borgen Sørensen Bin Zhang Min Yang | 2021 | Journal of Environmental Sciences2021，33，12： | 2 |
| 15 | Treatment of bum scarusing a carbon dioxide fractional laser显示文摘 | Sung Bin Cho MD Sang Ju Lee Ph D | 2010 | J Drugs Dermatol2010，9，2： | 1 |
| 16 | Do antiplatelets increase the risk of bleeding after endoscopic submucosal dissection of gastric neoplasms?显示文摘 | Joo Hyun Lim Sang Gyun Kim Ji Won Kim Yoon Jin Choi Jieun Kwon Ji Yeon Kim Yun Bin Lee Jeongmin Choi Jong Pil Im Joo Sung Kim Hyun Chae Jung In Sung Song | 2012 | Gastrointestinal Endoscopy2012，，4： | 1 |
| 17 | Effects of atorvastatin pretreatment on infarct size in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention显示文摘 | Joo-Yong Hahn Hyun-Joong Kim Yu Jeong Choi Sang-Ho Jo Hak Jin Kim Sahng Lee Kyoung-Ju Ahn Young Bin Song Jin-Ho Choi Seung-Hyuk Choi Young-Jin Choi Kyung-Han Lee Sang Hoon Lee Hyeon-Cheol Gwon | 2011 | American Heart Journal2011，，6： | 1 |
| 18 | Melanoma-associated antigen genes – An update显示文摘 | Meixiang Sang Lifang Wang Chunyan Ding Xinliang Zhou Bin Wang Ling Wang Yishui Lian Baoen Shan | 2010 | Cancer Letters2010，，： | 1 |
| 19 | Stock Index Futures Listing and Structural Change In Time - Varying Volatility显示文摘 | Sang Bin Lee Ki Yool Ohk | 1992 | Journal of Futures Markets1992，12，5： | 1 |
| 20 | Freeway Slope Stability E- valuation Based on Multi -Level Fuzzy Neural Network 显示文摘 | Wu Yankai Sang Xiansong Niu Bin | 2012 | Advanced Materials Research2012，430，： | 1 |
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