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| 1 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 2 | Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma显示文摘AIM: To assess the clinical features and prognosis of 151 patients with extrahepatic metastases from primary hepatocellular carcinoma (HCC), and describe the treatment strategy for such patients. METHODS: After the diagnosis of HCC, all 995 consecutive HCC patients were followed up at regular intervals and 151 (15.2%) patients were found to have extrahepatic metastases at the initial diagnosis of primary HCC or developed such tumors during the follow-up period. We assessed their clinical features, prognosis, and treatment strategies. RESULTS: The most frequent site of extrahepatic metastases was the lungs (47%), followed by lymph nodes (45%), bones (37%), and adrenal glands (12%). The cumulative survival rates after the initial diagnosis of extrahepatic metastases at 6, 12, 24, and 36 mo were 44.1%, 21.7%, 14.2%, 7.1%, respectively. The median survival time was 4.9 mo (range, 0-37 mo). Fourteen patients (11%) died of extrahepatic HCC, others died of primary HCC or liver failure. CONCLUSION: The prognosis of HCC patients with extrahepatic metastases is poor. With regard to the cause of death, many patients would die of intrahepatic HCC and few of extrahepatic metastases. Although most of HCC patients with extrahepatic metastases should undergo treatment for the primary HCC mainly, treatment of extrahepatic metastases in selected HCC patients who have good hepatic reserve, intrahepatictumor stage (T0-T2), and are free of portal venous invasion may improve survival. | Kiminori Uka Hiroshi Aikata Shintaro Takaki Hiroo Shirakawa Soo Cheol Jeong Keitaro Yamashina Akira Hiramatsu Hideaki Kodama Shoichi Takahashi Kazuaki Chayama | 2007 | World Journal of Gastroenterology2007，13，3： | 44 |
| 3 | Long-term result of endoscopic Histoacryl (N-butyl-2-cyanoacrylate)injection for treatment of gastric varices显示文摘AIM:To evaluate the long-term efficacy and safety of endoscopic obliteration with Histoacryl for treatment of gastric variceal bleeding and prophylaxis.METHODS:Between January 1994 and March 2010 at SoonChunHyang University Hospital,a total of 127 patients with gastric varices received Histoacryl injections endoscopically.One hundred patients underwent endoscopic Histoacryl injections because of variceal bleeding,the other 27 patients received such injections as a prophylactic procedure.RESULTS:According to Sarin classification,56 patients were GOV1,61 patients were GOV2 and 10 patients were IGV.Most of the varices were large(F2 or F3,111 patients).The average volume of Histoacryl per each session was 1.7±1.3 cc and mean number of sessions was 1.3±0.6.(1 session-98 patients,2 sessions-25 patients,≥3 sessions-4 patients).Twenty-seven patients with high risk of bleeding(large or fundal or RCS+or Child C) received Histoacryl injection as a primary prophylactic procedure.In these patients,hepatitis B virus was the major etiology of cirrhosis,25 patients showed GOV1 or 2(92.6%)and F2 or F3 accounted for 88.9%(n=24).The rate of initial hemostasis was 98.4%and recurrent bleeding within one year occurred in 18.1%of patients.Successful hemostasis during episodes of rebleeding was achieved in 73.9%of cases.Median survival was 50 mo (95%CI 30.5-69.5).Major complications occurred in 4 patients(3.1%).The rebleeding rate in patients with hepatocellular carcinoma or GOV2 was higher than in those with other conditions.None of the 27 subjects who were treated prophylactically experienced treatment-related complications.Cumulative survival rates of the 127 patients at 6 mo,1,3,and 5 years were 92.1%,84.2%,64.2%,and 45.3%,respectively.The 6 mo cumulative survival rate of the 27 patients treated prophylactically was 75%.CONCLUSION:Histoacryl injection therapy is an effective treatment for gastric varices and also an effective prophylactic treatment of gastric varices which carry high risk of bleeding. | Eun Jung Kang Soung Won Jeong Jae Young Jang Joo Young Cho Sae Hwan Lee Hyun Gun Kim Sang Gyune Kim Young Seok Kim Young Koog Cheon Young Deok Cho Hong Soo Kim Boo Sung Kim | 2011 | World Journal of Gastroenterology2011，17，11： | 41 |
| 4 | Gene expression profiling:Canonical molecular changes and clinicopathological features in sporadic colorectal cancers显示文摘瞄准:为了调查其他或辅助的小径,在颜色包含了表面的肿瘤发生和肿瘤生长,可能决定在风险人口并且预言回答到治疗。方法:用微数组基因表示分析,我们在 84 分散的颜色相对正规分子的变化和 clinicopathological 特征分析了基因表示的模式表面的癌症病人,由肿瘤地点标准化了。差别的子集表示了基因被即时反向抄本的聚合酶链反应(RT-PCR ) 证实。结果:作为差别正在被表示识别的基因的最大的数字由 lymphovascular 或肿瘤房间并且由失配修理(MMR ) 的神经侵略由肿瘤地点,和下一个最大的数字缺点。在生物过程之中,有免疫力的反应显著地在在颜色期间观察的全部分子的变化被含有表面的肿瘤发生(P <
0.001 ) 。在 47 之中,差别表示了基因,(PISD, NIBP, BAI2, STOML1, MRPL21, MRPL16,和 MKKS ) 七最新被发现与肿瘤发生和肿瘤生长相关。最联系地点的分子的变化在基因表示上有不同效果,但是后者的效果有时是矛盾的。结论:我们证明几差别表示了基因在分散的颜色与正规分子的变化被联系表面的癌症,可能组成肿瘤发生的其他或辅助的小径。因为肿瘤地点是影响微分基因表示的主导的因素,地点特定的分析可以识别联系地点的小径并且提高班预言的精确性。 | Jin Cheon Kim Seon Young Kim Seon Ae Roh Dong-Hyung Cho Dae Dong Kim Jeong Hyun Kim Yong Sung Kim | 2008 | World Journal of Gastroenterology2008，14，43： | 36 |
| 5 | 目标定向的因素结构及其与自我效能感、目标设置和绩效关系的初步研究显示文摘 | 孟慧 Steve Jeong 范津砚 祝靖媛 肖承丽 | 2003 | 心理科学2003，26，1： | 31 |
| 6 | Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways显示文摘Wogonin is a plant flavonoid compound extracted from Scutellaria baicalensis(Huang-Qin or Chinese skullcap) and has been studied thoroughly by many researchers till date for its anti-viral, anti-oxidant, anti-cancerous and neuro-protective properties. Numerous experiments conducted in vitro and in vivo have demonstrated wogonin's excellent tumor inhibitory properties. The anticancer mechanism of wogonin has been ascribed to modulation of various cell signaling pathways, including serine-threonine kinase Akt(also known as protein kinase B) and AMP-activated protein kinase(AMPK) pathways, p53-dependent/independent apoptosis, and inhibition of telomerase activity. Furthermore, wogonin also decreases DNA adduct formation with a carcinogenic compound 2-Aminofluorene and inhibits growth of drug resistant malignant cells and their migration and metastasis, without any side effects. Recently, newly synthesized wogonin derivatives have been developed with impressive anti-tumor activity. This review is the succinct appraisal of the pertinent articles on the mechanisms of anti-tumor properties of wogonin. We also summarize the potential of wogonin and its derivatives used alone or as an adjunct therapy for cancer treatment. Furthermore, pharmacokinetics and side effects of wogonin and its analogues have also been discussed. | Do Luong Huynh Neelesh Sharma Amit Kumar Singh Simrinder Singh Sodhi ZHANG Jiao-Jiao Raj Kumar Mongre Mrinmoy Ghosh Nameun Kim Yang Ho Park Dong Kee Jeong | 2017 | Chinese Journal of Natural Medicines2017，15，1： | 32 |
| 7 | Anatomical resection of hepatocellular carcinoma: A critical review of the procedure and its benefits on survival显示文摘Hepatocellular carcinoma(HCC) is the sixth most common type of cancer and the third most frequent cause of cancer-related death. Advances in preoperative assessment of HCC(e.g., imaging studies and liver function tests), surgical techniques, and postoperative care have improved the surgical outcomes and survival of patients who undergo hepatic resection for HCC. However, in the last 20 years, the long-term survival after hepatectomy has remained unsatisfactory owing to the high rates of local recurrence and multicentric occurrence. Anatomical liver resection(AR) was introduced in the 1980 s. Although several studies have revealed tangible benefits of AR for HCC, these benefits are still debated. Because most HCCs occur in patients with liver cirrhosis and poor hepatic function, there are many factors that affect survival, including the surgical method. Nevertheless, many studies have documented the perioperative and long-term benefits of AR in various conditions. In this article, we review the results of several recently published, well-designed comparative studies of AR, to investigate whether AR provides real benefits on survival outcomes. We also discuss the potential pitfalls associated with this approach. | Koo Jeong Kang Keun Soo Ahn | 2017 | World Journal of Gastroenterology2017，23，7： | 32 |
| 8 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 9 | Diurnal Variations of Summer Precipitation in the Beijing Area and the Possible Effect of Topography and Urbanization显示文摘The present study examined the diurnal variations of summer precipitation in the Beijing area by using subdaily precipitation and wind observations. A combined effect of topography and urbanization on the characteristics of diurnal variations was suggested. It was shown that stations located in the plain areaexhibited typical night rain peaks, whereas those in the mountainous area exhibited clear afternoon peaks ofprecipitation diurnal variations. The precipitation peaks were associated with wind fields around the Beijing area, which were found to be highly modulated by mountain-valley circulation and urban-country circulation.The lower-tropospheric wind exhibited a clear diurnal shift in its direction from north at 0800 LST to southat 2000 LST, which reflected mountain-valley circulation. The transitions from valley to mountain windand the opposite generally happened after sunset and sunrise, respectively, and both occurred earlier for thestations located closer to mountains. By comparing the diurnal variations of precipitation at stations in anortheast suburb, an urban area, and a southwest suburb, it was revealed that the northeast suburb grouphad the highest normalized rainfall frequency, but the southwest group had the lowest from late afternoon tolate evening. On the contrary, in the early morning from about 0200 to 1000 LST, the southwest group andurban group had the highest normalized rainfall frequency. This pattern might originate from the combined effects of mountain-valley topography and urbanization. | 殷水清 李维京 Deliang CHEN Jee-Hoon JEONG 郭文利 | 2011 | Advances in Atmospheric Sciences2011，28，4： | 26 |
| 10 | YSDP102钻孔有孔虫动物群与南黄海东南部古水文重建显示文摘所研究的YSDP1 0 2钻孔岩心 (33°49.496′N ,1 2 5°45.0 0 9′E)是由韩国能源研究所和中国国土资源部海洋地质研究所于 1 995年 8月联合取自南黄海东南部水深 62m的巨厚泥质沉积区内 ,岩心长 60 65m。通过对岩心沉积物中浮游和底栖有孔虫动物群的分析 ,结合相应的AMS1 4 C测年数据 ,对黄海暖流及与其相伴生的南黄海东南部冷水体的形成及演化进行了初步的探讨。结果表明 ,黄海暖流及与其相伴生的南黄海东南部冷水体形成于距今约640 0日历年前。形成伊始 ,冷水体处于明显的强势状态 ,而暖流的强度却相对较弱 ,这一过程约持续了 2 2 0 0年左右 ,是南黄海东南部巨厚泥质沉积区的主要堆积期。直到距今 42 0 0日历年前后 ,黄海暖流的影响强度开始加强 ,冷水体相对减弱 ,直至达到现代的水文状态。 | 李铁刚 李绍全 苍树溪 刘健 Jeong Hae Chang | 2000 | 海洋与湖沼2000，31，6： | 25 |
| 11 | Effects of Momentum Ratio and Weber Number on Spray Half Angles of Liquid Controlled Pintle Injector显示文摘一个舵栓注射者为扼杀一台液体火箭引擎并且减少引擎重量是有益的。这研究为液体气体燃料在舵栓注射者的水花特征上以各种各样的注射条件探索动量比率和威伯数字的效果。一张液体表从一张中心舵栓嘴被注射,它被一口煤气的喷气从环形的差距打破。燃料的压力落下,和舵栓洞距离被看作控制变量;使用 0.1 1.0 液体注射作为为压力的一个酒吧落下,为为舵栓洞距离的煤气的喷气和 0.2 1.0 公里的压力落下的 0.010.2 酒吧。分泌物系数在 0.75 公里的舵栓洞距离前线性地被减少然后,系数稍微被增加。水花图象被一个互补金属氧化物半导体照相机与高分辨率捕获。然后,阴影和反映的图象被分析。水花分布被 patternator 从一个舵栓尖端与 50 公里的轴的距离测量。最后,角度有指数地减少的水花一半动量比率由威伯数字划分了的关联。另外,水花一半从水花分发的角度与从捕获的图象测量的那些相比被低估。 | Min Son Kijeong Yu Jaye Koo Oh Chae Kwon Jeong Soo Kim | 2015 | Journal of Thermal Science2015，24，1： | 26 |
| 12 | State-of-the-art preoperative staging of gastric cancer by MDCT and magnetic resonance imaging显示文摘Gastric cancer is one of the most common and fatal cancers.The importance of accurate staging for gastric cancer has become more critical due to the recent introduction of less invasive treatment options,such as endoscopic mucosal resection or laparoscopic surgery.The tumor-node-metastasis staging system is the generally accepted staging system for predicting the prognosis of patients with gastric cancer.Multidetector row computed tomography(MDCT)is a widely accepted imaging modality for the preoperative staging of gastric cancer that can simultaneously assess locoregional staging,including the gastric mass,regional lymph nodes,and distant metastasis.The diagnostic performance of MDCT for T-and N-staging has been improved by the technical development of isotropic imaging and 3D reformation.Although magnetic resonance imaging(MRI)was not previously used to evaluate gastric cancer due to the modality’s limitations,the development of high-speed sequences has made MRI a feasible tool for the staging of gastric cancer. | Joon-Il Choi Ijin Joo Jeong Min Lee | 2014 | World Journal of Gastroenterology2014，20，16： | 26 |
| 13 | Endoscopic removal of gastric ectopic pancreas:An initial experience with endoscopic submucosal dissection显示文摘AIM:To evaluate the therapeutic usefulness and safety of endoscopic resection in patients with gastric ectopic pancreas.METHODS:A total of eight patients with ectopic pancreas were included.All of them underwent endoscopic ultrasonography before endoscopic resection.Endo-scopic resection was performed by two methods:endo-scopic mucosal resection(EMR)by the injection-and-cut technique or endoscopic mucosal dissection(ESD).RESULTS:We planned to perform EMR in all eight cases but EMR was successful in only four cases.In the other four cases,saline spread into surrounding normal tissues and the lesions becameattened,which made it impossible to remove them by EMR.Inthose four cases,we performed ESD and removed the lesions without any complications.CONCLUSION:If conventional EMR is difficult to remove gastric ectopic pancreas,ESD is a feasible alternative method for successful removal. | Dong Yup Ryu Gwang Ha Kim Do Youn Park Bong Eun Lee Jae Hoon Cheong Dong Uk Kim Hyun Young Woo Jeong Heo Geun Am Song | 2010 | World Journal of Gastroenterology2010，16，36： | 24 |
| 14 | Cortex cinnamomi extract prevents streptozotocin- and cytokine-induced β-cell damage by inhibiting NF-κB显示文摘AIM: To clarify the mechanism underlying the anti-diabetic activities of cortex cinnamomi extract (CCE). METHODS: To induce in vivo diabetes, mice were injected with streptozotocin (STZ) via a tail vein (100 mg STZ/kg body weight). To determine the effects of CCE, mice were administered CCE twice daily for 7 d by oral gavage starting 1 wk before the STZ injection. Blood glucose and plasma insulin concentration were measured as an index of diabetes. Also, to induce cytotoxicity of RINm5F cells, we treated with cytokines (IL-1β(2.0 ng/mL) and IFN-γ(100 U/mL)). Cell viability and nitric oxide production were measured colorimetrically. Inducible nitric oxide synthase (iNOS) mRIMA and protein expression were determined by RT-PCR and Western blotting, respectively. The activation of NF-κB was assayed by using gel mobility shift assays of nuclear extracts. RESULTS: Treatment of mice with STZ resulted in hyperglycemia and hypoinsulinemia, which was further evidenced by immunohistochemical staining of islets. However, the diabetogenic effects of STZ were completely prevented when mice were pretreated with CCE. The inhibitory effect of CCE on STZ-induced hyperglycemia was mediated through the suppression of iNOS expression. In rat insulinoma RINm5F cells, CCE completely protected against interleukin-1βand interferon-γ-mediated cytotoxicity. Moreover, RINm5F cells incubated with CCE showed significant reductions in interleukin-lp and interferon-γ-induced nitric oxide production and in iNOS mRNA and protein expression, and these findings correlated well with in vivo observations. CONCLUSION: The molecular mechanism by which CCE inhibits iNOS gene expression appears to involve the inhibition of NF-κB activation. These results reveal the possible therapeutic value of CCE for the prevention of diabetes mellitus progression. | Kang-Beom Kwon Eun-Kyung Kim Eun-Sil Jeong Young-Hoon Lee Young-Rae Lee Jin-Woo Park Do-Gon Ryu Byung-Hyun Park | 2006 | World Journal of Gastroenterology2006，12，27： | 24 |
| 15 | Anti-fungal and anti-bacterial activities of ethanol extracts of selected traditional Chinese medicinal herbs显示文摘Objective:To evaluate in ritro antimicrobial activities of selected 58 ethno-medicinal plant extracts with a view to assess their therapeutic potential.Methods:A total of 58 traditional Chinese medicinal plants were carefully selected based on the literature review and their traditional use.The antimicrobial activities of ethanol extracts of these medicinal plants were tested against fungi(Aspergillus funigaius),yeast(Candida albicans),gram-negative(Acirelobacter haumannii and Pseudornnruis aeruginosa)and gram-positive bacteria(Staphglococcus aureus).The activities were tested at three different concentrations of 1.00,0.10 and 0.01 mg/mL.The data was analysed using Gene data Screener program.Results:The measured antimicrobial activities indicated that out of the 58 plant extracts,15 extracts showed anti-fungal activity and 23 extracts exhibited anti-bacterial activity.Eight plant extracts have exhibited both anti-bacterial and anti-fungal activities.For instance,Eucommia ulmoides,Pohgonum cuspidcrtum,Poria cocas and Uncaria rhineophylla showed activity against both bacterial and fungal strains,indicating their broad spectrum of activity.Conclusions:The results revealed that the ethanol extracts of 30 plants out of the selected 58 possess significant antimicrobial activities.It is interesting to note that the findings from the current study are consistent with the traditional use.A clear correlation has also been found between the antimicrobial activity and the flavonoid content of the plant extracts which is in agreement with the literature.Hence.the results presented here can be used to guide the selection of potential plant species for the isolation and structure elucidation of novel antimicrobial compounds in order to establish the structure-activity relationship.This in turn is expected to lead the way to the discovery of novel antimicrobial agents for therapeutic use. | Lin Zhang Anjaneya S.Ravipati Sundar R Koyyalamudi Sang Chul Jeong Narsimha Reddy John Bartlett Paul T.Smith Mercedes de la Cruz Maria Cndida Monteiro ngeles Melguizo Ester Jimnez Francisca Vicente | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，9： | 23 |
| 16 | Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells显示文摘AIM: The genes were divided into seven categories according to biological function; apoptosis-reiated, immune response-related, signal transduction-related, cell cyclerelated, cell growth-related, stress response-related and transcription-related genes.METHODS: We compared the gene expression profiles of SNU-C4 cells between amygdalin-treated (5 mg/mL,24 h) and non-treated groups using cDNA microarray analysis. We selected genes downregulated in cDNA microarray and investigated mRNA levels of the genes by RT-PCR. RESULTS: Microarray showed that amygdalin downregulated especially genes belonging to cell cycle category: exonuclease 1 (EXO1), ATP-binding cassette, sub-family F, member 2 (ABCF2), MRE11 meiotic recombination 11 homolog A (MRE114), topoisomerase (DNA) I (TOP1), and FK506 binding protein 12-rapamycin-associated protein 1 (FRAP1). RT-PCR analysis revealed that mRNA levels of these genes were also decreased by amygdalin treatment in SNU-C4 human colon cancer cells.CONCLUSION: These results suggest that amygdalin have an anticancer effect via downregulation of cell cycle-related genes in SNU-C4 human colon cancer cells,and might be used for therapeutic anticancer drug. | Hae-Jeong Park Seo-Hyun Yoon Long-Shan Han Long-Tai Zheng Kyung-Hee Jung Yoon-Kyung Uhm Je-Hyun Lee Ji-Seon Jeong Woo-Sang Joo Sung-Vin Yim Joo-Ho Chung Seon-Pyo Hong | 2005 | World Journal of Gastroenterology2005，11，33： | 23 |
| 17 | Salinity intrusion characteristics analysis using EFDC model in the downstream of Geum River显示文摘As social interest in the environmental conservation and ecological restoration has recently increased,more research works have been done to resolve problems concerning environmental management of estuaries.In this study,a three-dimensional numerical model,Environmental Fluid Dynamics Code (EFDC) was used in the analysis of the salinity intrusion characteristics in the downstream of Geum River.The numerical simulation was performed to investigate the influence range for salinity intrusion when the gates were fully opened.The conditions used for simulation were the four flow regimes in Geum River Basin,Korea.Results indicated that the ranges of salinity intrusion from the barrage were 50.72 km (drought flow),48.87 km (low flow),46.56 km (normal flow) and 42.10 km (flood flow).These results indicated that the EFDC model used for numerical simulation has high accuracy.The result concluded in this study can be used as a basis in understanding the extent of salinity intrusion effects at different flow rates. | Sangman Jeong Kyusung Yeon Youngteck Hur Kukryul Oh | 2010 | Journal of Environmental Sciences2010，22，6： | 22 |
| 18 | Chronic gastrointestinal symptoms and quality of life in the Korean population显示文摘AIM: To evaluate the prevalence of chronic gastroin-testinal symptoms and their impact on health-related quality of life (HRQOL) in the Korean population. METHODS: A cross-sectional survey, using a reliable and valid Rome Ⅱ based questionnaire, was per-formed on randomly selected residents, between 18 and 69 years in age. All respondents were interviewed at their homes or offices by a team of interviewers. The impact of chronic gastrointestinal symptoms on HRQOL was assessed using the Korean version of the 36-item Short-Form general health survey (SF-36). RESULTS: Of the 1807 eligible subjects, 1417 (78.4%: male 762; female 655) were surveyed. Out of the respondents, 18.6% exhibited at least one chronic gastrointestinal symptom. The prevalence of gastro- esophageal reflux disease (GERD), defined as heart- burn and/or acid regurgitation experienced at least weekly, was 3.5% (95% CI, 2.6-4.5). The prevalence of uninvestigated dyspepsia, irritable bowel syndrome (IBS) and chronic constipation based on Rome Ⅱ cri- teria were 11.7% (95% CI, 10.1-13.5), 2.2% (95%CI, 1.5-3.1), and 2.6% (95% CI, 1.8-3.5) respectively. Compared with subjects without chronic gastrointesti- nal symptoms (n = 1153), those with GERD (n = 50), uninvestigated dyspepsia (n = 166) and IBS (n = 31) had signifi cantly worse scores on most domains of the SF-36 scales. CONCLUSION: The prevalence of GERD, uninvesti-gated dyspepsia and IBS were 3.5%, 11.7% and 2.2% respectively, in the Korean population. The health- related quality of life was signifi cantly impaired in sub-jects with GERD, uninvestigated dyspepsia and IBS in this community. | Jeong-Jo Jeong Myung-Gyu Choi Young-Seok Cho Seung-Geun Lee Jung-Hwan Oh Jae-Myung Park Yu-Kyung Cho In-Seok Lee Sang-Woo Kim Sok-Won Han Kyu-Yong Choi In-Sik Chung | 2008 | World Journal of Gastroenterology2008，14，41： | 21 |
| 19 | Mitophagy links oxidative stress conditions and neurodegenerative diseases显示文摘Mitophagy is activated by a number of stimuli, including hypoxia, energy stress, and increased oxidative phosphorylation activity. Mitophagy is associated with oxidative stress conditions and central neurodegenerative diseases. Proper regulation of mitophagy is crucial for maintaining homeostasis; conversely, inadequate removal of mitochondria through mitophagy leads to the generation of oxidative species, including reactive oxygen species and reactive nitrogen species, resulting in various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. These diseases are most prevalent in older adults whose bodies fail to maintain proper mitophagic functions to combat oxidative species. As mitophagy is essential for normal body function, by targeting mitophagic pathways we can improve these disease conditions. The search for effective remedies to treat these disease conditions is an ongoing process, which is why more studies are needed. Additionally, more relevant studies could help establish therapeutic conditions, which are currently in high demand. In this review, we discuss how mitophagy plays a significant role in homeostasis and how its dysregulation causes neurodegeneration. We also discuss how combating oxidative species and targeting mitophagy can help treat these neurodegenerative diseases. | Ulfuara Shefa Na Young Jeong In Ok Song Hyung-Joo Chung Dokyoung Kim Junyang Jung Youngbuhm Huh | 2019 | Neural Regeneration Research2019，14，5： | 21 |
| 20 | Imaging diagnosis of pancreatic cancer:A state-of-the-art review显示文摘Pancreatic cancer(PC)remains one of the deadliest cancers worldwide,and has a poor,five-year survival rate of 5%.Although complete surgical resection is the only curative therapy for pancreatic cancer,less than20%of newly-diagnosed patients undergo surgical resection with a curative intent.Due to the lack of early symptoms and the tendency of pancreatic adenocarcinoma to invade adjacent structures or to metastasize at an early stage,many patients with pancreatic cancer already have advanced disease at the time of their diagnosis and,therefore,there is a high mortality rate.To improve the patient survival rate,early detection of PC is critical.The diagnosis of PC relies on computed tomography(CT)and/or magnetic resonance imaging(MRI)with magnetic resonance cholangiopancreatography(MRCP),or biopsy or fine-needle aspiration using endoscopic ultrasound(EUS).Although multi-detector row computed tomography currently has a major role in the evaluation of PC,MRI with MRCP facilitates better detection of tumors at an early stage by allowing a comprehensive analysis of the morphological changes of the pancreas parenchyma and pancreatic duct.The diagnosis could be improved using positron emission tomography techniques in special conditions in which CT and EUS are not completely diagnostic.It is essential for clinicians to understand the advantages and disadvantages of the various pancreatic imaging modalities in order to be able to make optimal treatment and management decisions.Our study investigates the current role and innovative techniques of pancreatic imaging focused on the detection of pancreatic cancer. | Eun Sun Lee Jeong Min Lee | 2014 | World Journal of Gastroenterology2014，20，24： | 21 |
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