|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Obstructive sleep apnea is independently associated with insulin resistance显示文摘 | Marys MIP Bing LAM Matthew MTNG | 2002 | Respir Crit Care Med2002，165，5： | 1 |
| 2 | Femtosecond laser-induced surface wettability modification of polystyrene surface显示文摘In this paper, we demonstrated a simple method to create either a hydrophilic or hydrophobic surface. With femtosecond laser irradiation at different laser parameters, the water contact angle (WCA) on polystyrene’s surface can be modified to either 12.7° or 156.2° from its original WCA of 88.2°. With properly spaced micro-pits created, the surface became hydrophilic probably due to the spread of the water droplets into the micro-pits. While with properly spaced micro-grooves created, the surface became rough and more hydrophobic. We investigated the effect of laser parameters on WCAs and analyzed the laser-treated surface roughness, profiles and chemical bonds by surface profilometer, scanning electron microscope (SEM) and X-ray photoelectron spectroscopy (XPS). For the laser-treated surface with low roughness, the polar (such as C—O, C=O, and O—C=O bonds) and non-polar (such as C—C or C—H bonds) groups were found to be responsible for the wettability changes. While for a rough surface, the surface roughness or the surface topography structure played a more significant role in the changes of the surface WCA. The mechanisms involved in the laser surface wettability modification process were discussed. | Bing Wang XinCai Wang HongYu Zheng YeeCheong Lam | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，12： | 1 |
| 3 | Isolation of Nipah virus from Malaysian Island flying-foxes显示文摘 | Kaw Bing Chua Chong Lek Koh Poh Sim Hooi Kong Fatt Wee Jenn Hui Khong Beng Hooi Chua Yee Peng Chan Mou Eng Lim Sai Kit Lam | 2002 | Microbes and Infection2002，，： | 1 |
| 4 | Obstructive sleep ap- nea and the metabolic syndrome in community - based Chinese a- dults in Hong Kong显示文摘 | Jamie C M Lam Bing Lam Chi-leung Lam | 2006 | Respiratory Medicine2006，100，： | 1 |
| 5 | Obst ructive sleep apnea is independently associated wit h insulin resistance显示文摘 | Marys MIP Bing LAM Matt hew MTNG | 2002 | Am J Respir Crit Care Med2002，165，5： | 1 |
| 6 | Application of biomarkers in sentinel lymph node biopsy for the management of breast cancer显示文摘Objective Sentinel lymph node in breast cancer is a predictor of the tumor's metastatic potential.Cytokines emerging from antitumor immune response might also target sentinel lymph node (SLN).In this study,we evaluated the cytokine profile including interleukin-8 (IL-8),interleukin-12 (IL-12),interferon-gamma (IFN-γ),and tumor necrosis factor alpha (TNF-α) for the T-cell response.Methods From January 2008 to August 2010,35 patients with breast mass underwent SLN biopsy in UNIMED Medical Institute.The specimens were formalin-fixed and paraffin-embedded for hematoxylin and eosin staining and immunohistochemistry with following markers:IL-8,IL-12,IFN-γ and TNF-α.The staining intensity was scored according to four grades:negative (-),weak expression (+),moderately positive expression (+ +),strong positive expression (+ + +).The correlation between the expression of cytokines and pathological characteristics were also analyzed using the Spearman Rank Correlation test.Results Out of 35 patients,SLN metastases were observed in 20 patients and among them,75% (15 /20) were strongly stained (+ + +) with IL-8 and moderately stained (+ +) with IL-12,but only 25% (5 /20) were strongly stained (+ + +) with IFN-γ and TNF-α.The expression of IL-8 was significantly associated with all tumor grades (r=0.639,P=0.00),estrogen receptor (r=0.778,P=0.01),progesterone receptor (r=0.759 P=0.00) and HER-2 /neu receptor (r=0.863 P=0.00).Conclusion The strong association between IL-8 expression and SLN metastases might highlight the prognostic significance of IL-8 in SLN. | Qing Liu Wings Tjing Yung Loo Adrian Yun San Yip Louis Wing Cheong Chow Elizabeth Lam Yan Ng Mary Ngan Bing Cheung | 2012 | 中华乳腺病杂志(电子版)2012，6，6： | 1 |
| 7 | Obstructive sleep apnea is independently associated with insulin resistance 显示文摘 | Marys MIP Bing LAM Matthew MTNG | 2002 | Am J Respir Crit Care Med2002，165，5： | 1 |
| 8 | Artificial intelligence-driven radiomics study in cancer:the role of feature engineering and modeling显示文摘Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’anatomy.However,the interpretation of medical images can be highly subjective and dependent on the expertise of clinicians.Moreover,some potentially useful quantitative information in medical images,especially that which is not visible to the naked eye,is often ignored during clinical practice.In contrast,radiomics performs high-throughput feature extraction from medical images,which enables quantitative analysis of medical images and prediction of various clinical endpoints.Studies have reported that radiomics exhibits promising performance in diagnosis and predicting treatment responses and prognosis,demonstrating its potential to be a non-invasive auxiliary tool for personalized medicine.However,radiomics remains in a developmental phase as numerous technical challenges have yet to be solved,especially in feature engineering and statistical modeling.In this review,we introduce the current utility of radiomics by summarizing research on its application in the diagnosis,prognosis,and prediction of treatment responses in patients with cancer.We focus on machine learning approaches,for feature extraction and selection during feature engineering and for imbalanced datasets and multi-modality fusion during statistical modeling.Furthermore,we introduce the stability,reproducibility,and interpretability of features,and the generalizability and interpretability of models.Finally,we offer possible solutions to current challenges in radiomics research. | Yuan-Peng Zhang Xin-Yun Zhang Yu-Ting Cheng Bing Li Xin-Zhi Teng Jiang Zhang Saikit Lam Ta Zhou Zong-Rui Ma Jia-Bao Sheng Victor CWTam Shara WYLee Hong Ge Jing Cai | 2024 | Military Medical Research2024，11，1： | 0 |
| 9 | Cancer cell employs a microenvironmental neural signal transactivating nucleus-mitochondria coordination to acquire stemness显示文摘Cancer cell receives extracellular signal inputs to obtain a stem-like status,yet how tumor microenvironmental(TME)neural signals steer cancer stemness to establish the hierarchical tumor architectures remains elusive.Here,a pan-cancer transcriptomic screening for 10852 samples of 33 TCGA cancer types reveals that cAMP-responsive element(CRE)transcription factors are convergent activators for cancer stemness.Deconvolution of transcriptomic profiles,specification of neural markers and illustration of norepinephrine dynamics uncover a bond between TME neural signals and cancer-cell CRE activity.Specifically,neural signal norepinephrine potentiates the stemness of proximal cancer cells by activating cAMP-CRE axis,where ATF1 serves as a conserved hub.Upon activation by norepinephrine,ATF1 potentiates cancer stemness by coordinated trans-activation of both nuclear pluripotency factors MYC/NANOG and mitochondrial biogenesis regulators NRF1/TFAM,thereby orchestrating nuclear reprograming and mitochondrial rejuvenating.Accordingly,single-cell transcriptomes confirm the coordinated activation of nuclear pluripotency with mitochondrial biogenesis in cancer stem-like cells.These findings elucidate that cancer cell acquires stemness via a norepinephrine-ATF1 driven nucleus-mitochondria collaborated program,suggesting a spatialized stemness acquisition by hijacking microenvironmental neural signals. | Bin He Rui Gao Shasha Lv Ailin Chen Junxiu Huang Luoxuan Wang Yunxiu Feng Jiesi Feng Bing Liu Jie Lei Bing Deng Bin He Bai Cui Fei Peng Min Yan Zifeng Wang Eric W-F Lam Bilian Jin Zhiming Shao Yulong Li Jianwei Jiao Xi Wang Quentin Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，8： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员