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| 1 | Outbreak of Dengue Fever in Central China,2013显示文摘In 2013,the first dengue fever(DF) outbreak in central China was reported in the central of Henan province,northern temperate regions,although they have been sequentially recorded in Southern China.106 suspected DF cases were reported and 73 patients were confirmed dengue virus type 3(DEN-3) infections.62/392(15.8%) local health persons showed DEN antibodies positive.To this day Henan is the northernmost province in China which has been reported about outbreak of DF and what is important is that it warns us the endemic range of DF has been expanded geographically in China. | HUANG Xue Yong MA Hong Xia WANG Hai Feng DU Yan Hua SU Jia LI Xing Le TANG Xiao Yan MA Hong Peng ZU Bing Can ZHANG Qiao Hong CHEN Hao Min XU Bian Li | 2014 | Biomedical and Environmental Sciences2014，27，11： | 30 |
| 2 | Antisense to cyclin D1 reverses the transformed phenotype of human gastric cancer cells显示文摘INTRODUCTIONStudiesonthefunctionsofcelularprotooncogenesandtumorsuppresorgenesindicatethatmostofthesegenesmediatesignaltrans... | CHEN Bing 1, ZHANG Xue Yong 2, ZHANG Yu Jing 3, ZHOU Ping 3, GU Yan 4 and FAN Dai Ming 2 | 1999 | World Journal of Gastroenterology1999，5，1： | 23 |
| 3 | EXPERIMENTAL STUDY OF FLOWFIELD STRUCTURE AROUND AN OGIVE-CYLINDER显示文摘The flowfield structure and their aerodynamic characteristics over an ogive cylinder were studied by means of flow visualization and surface pressure measurement in a water tunnel and a wind tunnel. The existence of multi asymmetric vortices over long slender bodies was experimentally confirmed at large angles of attack and in the subcritical Reynolds number range. The spatial 3 D characteristics of the multi vortices system were analyzed and a physical model was developed. The topological structure of different patterns in cross flow plane was studied and the mechanism governing the formation of asymmetric vortices and multi vortices was discussed from the viewpoint of stability of the topological structure. It was concluded that the maximum in the sectional side force distribution curve are not caused by the shedding of higher position vortex, but by the cross over to the symmetric plane of the lower position vortex. | Ph.D.Candidate:Wang Gang Fluid Mechanics Institute, Beijing University of Aeronautics and Astronautics, Beijing 100083, China,Supervisor: Deng Xue ying (Beijing University of Aeronautics and Astronautics) Members of Dissertation Defense Committee: Tong Bing gang (Graduate School of the Chinese Academy of Sciences),Chairman Gu Zhi fu (Peking University) Yang Qi de (China Aerodynamics Research and Development Center) Lv Zhi yong (Beijing University of Aeronautics and Astronautics) Liu Pei qing (Beijing University of Aeronautics and Astronautics) | 2003 | Journal of Hydrodynamics2003，15，5： | 18 |
| 4 | Impact of alanyl-glutamine dipeptide on severe acute pancreatitis in early stage显示文摘AIM:To evaluate the therapeutic effect of alanyl- glutamine dipeptide (AGD) in the treatment of severe acute pancreatitis (SAP) in early and advanced stage. METHODS: Eighty patients with SAP were randomized and received 100 mL/d of 20% AGD intravenously for 10 d starting either on the day of (early treatment group) or 5 d after (late treatment group) admission. Groups had similar demographics, underlying diseases, Ranson score, Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ) score, and Balthazar’s computed tomography (CT) score at the beginning of the study and underwent similar other medical and nutritional management. RESULTS: The duration of acute respiratory distress syndrome (2.7 ± 3.3 d vs 12.7 ± 21.0 d, P < 0.01), renal failure (1.3 ± 0.5 d vs 5.3 ± 7.3 d, P < 0.01), acute hepatitis (3.2 ± 2.3 d vs 7.0 ± 7.1 d, P < 0.01), shock (1.7 ± 0.4 d vs 4.8 ± 3.1 d, P < 0.05), encephalopathy (2.3 ± 1.9 d vs 9.5 ± 11.0 d, P < 0.01) and enteroparalysis (2.2 ± 1.4 d vs 3.5 ± 2.2 d, P < 0.01) and hospital stay (28.8 ± 9.4 d vs 45.2 ± 27.1 d, P < 0.01) were shorter in the early treatment group than in the late treatment group. The 15-d APACHE Ⅱ score was lower in the early treatment group than in the late treatment group (5.0 ± 2.4 vs 8.6 ± 3.6, P < 0.01). The infection rate (7.9% vs 26.3%, P < 0.05), operation rate (13.2% vs 34.2%, P < 0.05) and mortality (5.3% vs 21.1%, P < 0.05) in the early treatment group were lower than in the late treatment group.CONCLUSION: Early treatment with AGD achieved a better clinical outcome in SAP patients. | Ping Xue Li-Hui Deng Qing xia Zhao-Da Zhang Wei-Ming Hu Xiao-Nan Yang Bing Song Zong-Wen Huang | 2008 | World Journal of Gastroenterology2008，14，3： | 15 |
| 5 | Using Fuzzy Theory and Variable Weights for Water Quality Evaluation in Poyang Lake, China显示文摘Achieving water purity in Poyang Lake has become a major concern in recent years, thus appropriate evaluation of spatial and temporal water quality variations has become essential. Variations in 11 water quality parameters from 15 sampling sites in Poyang Lake were investigated from 2009 to 2012. An integrative fuzzy variable evaluation(IFVE) model based on fuzzy theory and variable weights was developed to measure variations in water quality. Results showed that: 1) only chlorophyll-a concentration and Secchi depth differed significantly among the 15 sampling sites(P < 0.01), whereas the 11 water quality parameters under investigation differed significantly throughout the seasons(P < 0.01). The annual variations of all water quality variables except for temperature, electrical conductivity, suspended solids and total phosphorus were considerable(P < 0.05). 2) The IFVE model was reasonable and flexible in evaluating water quality status and any possible ′bucket effect′. The model fully considered the influences of extremely poor indices on overall water quality. 3) A spatial analysis indicated that anthropogenic activities(particularly industrial sewage and dredging) and lake bed topography might directly affect water quality in Poyang Lake. Meanwhile, hydrological status and sewage discharged into the lake might be responsible for seasonal water quality variations. | LI Bing YANG Guishan WAN Rongrong ZHANG Lu ZHANG Yanhui DAI Xue | 2017 | Chinese Geographical Science2017，27，1： | 15 |
| 6 | An improved association-mining research for exploring Chinese herbal property theory: based on data of the Shennong's Classic of Materia Medica显示文摘Knowledge Discovery in Databases is gaining attention and raising new hopes for traditional Chinese medicine(TCM)researchers.It is a useful tool in understanding and deciphering TCM theories.Aiming for a better understanding of Chinese herbal property theory(CHPT),this paper performed an improved association rule learning to analyze semistructured text in the book entitled Shennong’s Classic of Materia Medica.The text was firstly annotated and transformed to well-structured multidimensional data.Subsequently,an Apriori algorithm was employed for producing association rules after the sensitivity analysis of parameters.From the confirmed 120 resulting rules that described the intrinsic relationships between herbal property(qi,flavor and their combinations)and herbal efficacy,two novel fundamental principles underlying CHPT were acquired and further elucidated:(1)the many-to-one mapping of herbal efficacy to herbal property;(2)the nonrandom overlap between the related efficacy of qi and flavor.This work provided an innovative knowledge about CHPT,which would be helpful for its modern research. | Rui Jin Zhi-jian Lin Chun-miao Xue Bing Zhang | 2013 | Journal of Integrative Medicine2013，11，5： | 14 |
| 7 | High glucose stimulates TNFα and MCP-1 expression in rat microglia via ROS and NF-KB pathways显示文摘 | Yi QUAN Chang-tao JIANG Bing XUE Shi-gong ZHU Xian WANG | 2011 | Acta Pharmacologica Sinica2011，32，2： | 12 |
| 8 | Surgical operation and re-operation for hepatocellular carcinoma with bile duct thrombosis显示文摘很少报告评估了的背景为在为有这研究的 .The 目的是调查起始的外科的功效的胆汁管血栓( BDT )的 hepatocellular 癌( HCC )的起始的外科以后的恶化的重新操作和为有 BDT 的 HCC 的随后的重新操作的功效,并且他们 prognosis.Methods 上的效果包括在我们的医院里经历了在 1998 和 2008 之间的激进的 hepatectomy 的有 BDT 的 28 个病人,有 HCC 的 880 个病人的临床的数据是 BDT 的 reviewed.The | WANG Ya-dong XUE Huan-zhou JIANG Qing-feng SHEN Quan WANG Lian-cai ZHANG Xiao LU Bing YU Miao LI Ke | 2010 | Chinese Medical Journal2010，，16： | 11 |
| 9 | ζ-Carotene Isomerase Suppresses Tillering in Rice through the Coordinated Biosynthesis of Strigolactone and Abscisic Acid显示文摘Rice tillering is an important agronomic trait affecting grain yield.Here,we identified a high-tillering mutant tillering20(t20),which could be restored to the wild type by treatment with the strigolactone(SL)analog rac-GR24.T20 encodes a chloroplast ζ-carotene isomerase(Z-ISO),which is involved in the biosynthesis of ca-rotenoids and their metabolites,SL and abscisic acid(ABA).The t20 mutant has reduced SL and ABA,raising the question of how SL and ABA biosynthesis is coordinated,and whether they have overlapping functions in tillering.We discovered that rac-GR24 stimulated T20 expression and enhanced all-trans-p-carotene biosynthesis.Importantly,rac-GR24 also stimulated expression of Oryza sativa 9-CIS-EPOXY-CAROTENOID DIOXYGENASE 1(OsNCED1)through induction of Oryza sativa HOMEOBOX12(0sHOX12),promoting ABA biosynthesis in shoot base.On the other hand,ABA treatment significantly repressed SL biosynthesis and the ABA biosynthetic mutants displayed elevated SL biosynthesis.ABA treatment reduced the number of basal tillers in both t20 and wild-type plants.Furthermore,while ABA-deficient mu-tants aba1 and aba2 had the same number of basal tillers as wild type,they had more unproductive upper tillers at maturity.This work demonstrates complex interactions in the biosynthesis of carotenoid,SLs and ABA,and reveals a role for ABA in the regulation of rice tillering. | Xue Liu Qingliang Hu Jijun Yan Kai Sun Yan Liang Meiru Jia Xiangbing Meng Shuang Fang Yiqin Wang Yanhui Jing Guifu Liu Dianxing Wu Chengcai Chu Steven M.Smith Jinfang Chu Yonghong Wang Jiayang Li Bing Wang | 2020 | Molecular Plant2020，13，12： | 11 |
| 10 | NIR-II ?uorescence in vivo confocal microscopy with aggregation-induced emission dots显示文摘Significantly reduced tissue scattering of fluorescence signals in the second near-infrared(NIR-Ⅱ,1,000–1,700 nm)spectral region offers opportunities for large-depth in vivo bioimaging.Nowadays,most reported works concerning NIR-II fluorescence in vivo bioimaging are realized by wide-field illumination and 2D-arrayed detection(e.g.,via InGaAs camera),which has high temporal resolution but limited spatial resolution due to out-of-focus signals.Combining NIR-II fluorescence imaging with confocal microscopy is a good approach to achieve high-spatial resolution visualization of biosamples even at deep tissues.In this presented work,a NIR-II fluorescence confocal microscopic system was setup.By using a kind of aggregation-induced emission(AIE)dots as NIR-II fluorescent probes,800 lm-deep 3D in vivo cerebrovascular imaging of a mouse was obtained,and the spatial resolution at 700 lm depth could reach 8.78 lm.Moreover,the time-correlated single photon counting(TCSPC)technique and femtosecond laser excitation were introduced into NIR-II fluorescence confocal microscopy,and in vivo confocal NIR-II fluorescence lifetime microscopic imaging(FLIM)of mouse cerebral vasculature was successfully realized. | Wenbin Yu Bing Guo Hequn Zhang Jing Zhou Xiaoming Yu Liang Zhu Dingwei Xue Wen Liu Xianhe Sun Jun Qian | 2019 | Science Bulletin2019，64，6： | 10 |
| 11 | Role of neuronal nitric oxide synthase and inducible nitric oxide synthase in intestinal injury in neonatal rats显示文摘瞄准:与肠的损害在新生的老鼠调查神经元的氮的氧化物 synthase ( nNOS )和可诱导的氮的氧化物 synthase ( i NOS )的动态变化和角色并且定义引起坏死小肠结肠炎( NEC )是否在粘膜与氮的氧化物 synthase ( NOS )的层次被联系影响的肠织物。方法:Wistar 老鼠在年龄的不到 24 h 与 5 mg/kg 收到了腹膜内注射脂肪的多糖(LPS ) 。回肠纸巾为 NEC 的组织学的评估并且为 nNOS 和 i NOS 的大小在 1, 3, 6, 12 和 24 h 追随者 LPS 挑战被收集。在肠的损害的度和 NOS 的层次之间的关联是坚定的。结果:注射 LPS 的小狗在损害分数对控制显示出重要增加。nNOS 蛋白质和 mRNA 的表示在 LPS 注射以后被减少。在 nNOS 蛋白质和在 24 h 以内的中部的肠的损害的等级之间有否定重要关联。i NOS 蛋白质和 mRNA 的表示显著地在肠的损害的山峰被增加。结论:nNOS 和 i NOS 在导致 LPS 的肠的损害起不同作用。小心应该在 NEC 有关 NOS 禁止者的潜在的治疗学的使用被施加。 | Hui Lu Bing Zhu Xin-Dong Xue | 2006 | World Journal of Gastroenterology2006，12，27： | 10 |
| 12 | The Craniofacial Morphology in Adult Patients with Unoperated Isolated Cleft Palate显示文摘Objective:To address the effect of intrinsic factors on craniofacial growth by analyzing the craniofacial morphology of unoperated isolated cleft palate in Chinese adult.Materials and Methods:This study included 37 nonsyndromic isolated cleft palate and 39 age and gender matched non-clefts.Twenty-six cephalometric measurements were employed to evaluate the facial morphology.Independent samples T test and Mann-Whitney U were used for comparison.Significant difference was defined at 95% level.Results:Data from this study showed patients with unoperated isolated cleft palate have a reduced maxillary sagittal length(ANS-PMP,A-PMP,P<0.05),a smaller ANB angle(ANB,P<0.05) and a retrusive ANS point(S-N-ANS,P<0.05;Ba-N-ANS,P<0.05).Measurements descripted position of maxilla(S-Ptm,P>0.05),depth of bony pharynx(Ba-PMP,P>0.05),anterior and posterior maxillary height(N-ANS,P>0.05;R-PMP,P>0.05) and mandible morphology(including linear measurements and angle measurements) did not show any significant difference between case and control groups.Conclusions:Patients with isolated cleft palate were characterized by maxillary retrusion.Mandible morphology and cranial basal morphology in isolated cleft palate showed no significant difference with nonclefts.Patients with isolated cleft palate are more vulnerable to cross bite than nonclefts.Intrinsic deficiencies did detrimental effect on maxilla sagittal length,but did no detrimental effect on maxilla position,mandible size and position. | Zhongtai Ye Xue Xu Adalet Ahmatjian Bing Shi | 2013 | Bone Research2013，1，2： | 9 |
| 13 | A Facile Synthetic Route to L-Phosphinothricin显示文摘A convenient and effective method for synthesis of L-phosphinothricin was described.The highlight was involved in a simple access to the key intermediate L-2-amino-4-chlorobutyricacid derivative from the inexpensive L-methionine. | Xue Song XU Han Bing TENG Guo Fu QIU Shu Cai LIANG Xian Ming HU | 2006 | Chinese Chemical Letters2006，17，2： | 9 |
| 14 | Puerarin prevents high glucose-induced apoptosis of Schwann cells by inhibiting oxidative stress显示文摘Oxidative stress may be the unifying factor for the injury caused by hyperglycemia in diabetic peripheral neuropathy. Puerarin is the major isoflavonoid derived from Radix puerariae and has been shown to be effective in increasing superoxide dismutase activity. This study sought to investigate the neuroprotective effect of puerarin on high glucose-induced oxidative stress and Schwann cell apoptosis in vitro. Intracellular reactive oxygen radicals and mitochondrial transmembrane potential were detected by flow cytometry analysis. Apoptosis was confirmed by TUNEL and oxidative stress was monitored using an enzyme-linked immunosorbent assay for the DNA marker 8-hydroxy-2-deoxyguanosine. The expression levels of bax and bcl-2 were analyzed by quantitative real-time reverse transcriptase-PCR, while protein expression of cleaved caspase-3 and -9 were analyzed by means of western blotting. Results suggested that puerarin treatment inhibited high glucose-induced oxidative stress, mitochondrial depolarization and apoptosis in a dose-dependent manner. Furthermore, puerarin treatment downregulated Bax expression, upregulated bcl-2 expression and attenuated the activation of caspase-3 and -9. Overall, our results indicated that puerarin antagonized high glucose-induced oxidative stress and apoptosis in Schwann cells. | Yingying Wu Bing Xue Xiaojin Li Hongchen Liu | 2012 | Neural Regeneration Research2012，7，33： | 8 |
| 15 | Accidental conus medullaris injury following combined epidural and spinal anesthesia in a pregnant woman with unknown tethered cord syndrome显示文摘In most adults,the conus medullaris ends at around the inferior margin of the first lumbar (L1) vertebral body)However,location of terminus of the conus medullaris is variable and even extends more distally in patients with diseases such as tethered cord syndrome (TCS).Here,we reported a conus medullaris injury following combined spinal and epidural anesthesia (CSEA) in a pregnant woman with unknown TCS. | XUE Ji-xiu LI Bing LAN Fei | 2013 | Chinese Medical Journal2013，，6： | 8 |
| 16 | Identification of quantitative trait loci for four morphologic traits under water stress in rice (Oryza sativa L.)显示文摘Late season drought coinciding with the rice booting to heading stage affects the development of plant height, panicle exsertion, and flag leaf size, and causes significant yield loss. In this study, a recombinant inbred line population derived from a cross between paddy and upland cultivars was used for data collection of the morphologic traits under well water and drought stress conditions. Drought stress was applied at the stage of panicle initiation in the field in 2002 and at the booting stage in PVC pipes in 2003. The data from stress conditions and their ratios (trait measured under stress condition/trait measured under well water condition) or differences (trait measured under stress condition minus trait measured under well water condition) were used for QTL analysis. Totally, 17 and 36 QTLs for these traits were identified in 2002 and 2003, respectively, which explained a range of 2.58%-29.82% of the phenotypic variation. Among them, six QTLs were commonly identified in the two years, suggesting that the drought stress in the two years was different. The genetic basis of these traits will provide useful information for improving rice late season drought resistance, and their application as indirect indices in rice late season drought resistance screening was also discussed. | Bing Yue Weiya Xue Lijun Luo Yongzhong Xing | 2008 | Journal of Genetics and Genomics2008，35，9： | 7 |
| 17 | Synthesis and plant-growth regulatory activities of novel imine derivatives containing 1H-1,2,4-triazole and thiazole rings显示文摘Eleven new imine derivatives 6 containing 1H-1,2,4-triazole and thiazole rings were synthesized by the condensation of 5-((1H- 1,2,4-triazol-1-yl)methyl)-4-tert-butylthiazol-2-amine with various substituted benzaldehydes.The structures of the title compounds were characterized by ~1H NMR,MS and elemental analysis.The plant-growth regulatory activities of these compounds were evaluated.The primary bioassay results indicated that these target compounds exhibited promising plant-growth regulatory activities... | Qin, Xue Yu, Hai Bo Dai, Hong Qin, Zhen Fang Zhang, Xin Bing, Gui Fang Wang, Ting Ting Fang, Jian Xin | 2010 | Chinese Chemical Letters2010，21，3： | 6 |
| 18 | Effect of Dandelion Extracts on the Proliferation of Ovarian Granulosa Cells and Expression of Hormone Receptors显示文摘 | Tong Wang Bing Xue Hui Shao Shu-Yu Wang Li Bai Cheng-Hong Yin Huan-Ying Zhao Yong-Chao Qi Le-Le Cui Xin He Yan-Min Ma | 2018 | Chinese Medical Journal2018，，14： | 6 |
| 19 | Epidemics of overweight and obesity among growing childhood in China between 1997 and 2009: Impact of Family Income, Dietary Intake, and Physical Activity Dynamics显示文摘 | Chang Su Bing Zhang You-Fa Wang Xiao-Fang Jia Hong Xue Hui-Jun Wang | 2015 | Chinese Medical Journal2015，，14： | 6 |
| 20 | 无声放电和电晕放电转化温室气体比较研究显示文摘在无声放电和电晕放电条件下 ,研究了温室气体甲烷和二氧化碳的转化特性 .实验结果表明 ,甲烷和二氧化碳在不同放电形式下反应得到不同的产物 .甲烷、二氧化碳电晕放电反应的主要产物是合成气 ,无声放电反应的产物包括合成气、烃、含氧化物和高聚物等 ,类似于Fischer- Tropsch合成的产物 ,但分布不符合 Schulz- Flory方程 .在实验条件下 ,电晕放电反应体系的能量产率是 2 .2 6 mol/ (k W· h) ,无声放电反应体系的为 0 .34 mol/ (k W· h) .输入功率对等离子体反应影响较显著 ,甲烷和二氧化碳转化率随体系输入功率的提高而很快增加 .将 13X分子筛催化剂引入无声放电反应 ,提高了烃类产物选择性 ,抑制了炭黑和高聚物的生成 ,但甲烷和二氧化碳转化率分别由 6 4.3%和 5 5 .4%降低至 5 1.6 %和 41.7% ,合成气的H2 / CO比由 1.7降至 1. | 姜涛 李明伟 李阳 许根慧 刘昌俊 Baldur Eliasson Xue Bing zhang | 2002 | 天津大学学报(自然科学与工程技术版)2002，35，1： | 6 |
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