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| 1 | Transcriptome Sequencing Reveals Astrocytes as a Therapeutic Target in Heat-Stroke显示文摘Heat-stroke is a serious form of hyperthermia with high mortality, and can induce severe central nervous system disorders. The neurovascular unit(NVU), which consists of vascular cells, glial cells, and neurons, controls blood-brain barrier(BBB) permeability and cerebral blood flow, and maintains the proper functioning of neuronal circuits. However, the detailed function of each BBB component in heat-stroke remains unknown. In order to interpret alterations caused by heat stress, we performed transcriptome comparison of neuron and astrocyte primary cultures after heat treatment. Differentially-expressed genes were then selected and underwent Gene Ontology annotation and Kyoto Encyclopedia of Genes and Genomes pathway analysis. Gene-act networks were also constructed, and the expression of pivotal genes was validated by quantitative PCR, as well as single-cell q PCR in heatstroke rats. Our work provides valuable information on the transcriptional changes in NVU cells after heat stress,reveals the diverse regulatory mechanisms of two of these cellular components, and shows that a cell-type-specificapproach may be a promising therapeutic strategy for heatstroke treatments. | Bing Niu Tao Zhang Huaiqiang Hu Bingzhen Cao | 2017 | Neuroscience Bulletin2017，33，6： | 8 |
| 2 | Inhibitory effect of icariin on expression of myelin inhibitory factors in the central nervous system of rats with focal cerebral ischemia显示文摘Icariin, the major active component of Chinese medicinal herb epimedium brevicornum maxim, is used widely in traditional Chinese medicine for the treatment of neurological diseases. However, the effects of icariin on myelin inhibitory factors are as yet unclear. In the present study, administration of icariin at 20 mg/kg showed a marked reduction in neurological deficit of middle cerebral artery occlusion rats. Icariin exhibited better inhibitory effects on myelin inhibitory factors: Nogo-A, myelin-associated glycoprotein and oligodendrocyte myelin glycoprotein in ischemia regions of middle cerebral artery occlusion rats compared with monosialotetrahexosylganglioside. These results indicate that icariin exhibits potent inhibitory effects on expression of myelin inhibitors after middle cerebral artery occlusion-induced focal cerebral ischemia in vivo. This effect may be mediated, at least in part, by the inhibition of both Nogo-A, myelin-associated glycoprotein and oligodendrocyte myelin glycoprotein activation, followed by the enhancement of axonal sprouting and regeneration, resulting in neurological functional recovery. | Huaiqiang Hu Yonghong Zhou Bingzhen Cao Xinlu Wang | 2010 | Neural Regeneration Research2010，5，16： | 7 |
| 3 | International experience of green development in Western China:an overall review of policy and practice显示文摘Green development emphasizes co-development between economic and environmental dimensions,and is a peoplecentered sustainable development approach.Western China demands green development,and international experience could provide necessary,unique and important help and support for Western China to achieve its green development goals.This paper has made a comprehensive overall review and analysis of international experience in green development policy and its implementation,in particular,OECD countries'(mostly Australia and Canada) experience have been analyzed following the major policy foci defined by the Task Force on Strategy and Policies on Environment and Development in Western China initiated by China Council for International Cooperation on Environment and Development(CCICED).Data and information were gathered from the field surveys and investigations,expert meetings,as well as literature review.The main sessions include policy framework and road map establishment,implementation and performance assessment,co-development between economic development and environmental protection,as well as green employment and poverty alleviation.The paper has addressed five policy considerations for the future promotion of green development in Western China. | Lin Zhen Jie Hu Bingzhen Du Jiyuan Liu Chuanzhun Sun Ruizi Wu Xin Long Qiang Zhang | 2015 | Chinese Journal of Population,Resources and Environment2015，13，4： | 5 |
| 4 | Process optimization with consideration of uncertainties——An overview显示文摘Optimization under uncertainty is a challenging topic of practical importance in the Process Systems Engineering.Since the solution of an optimization problem generally exhibits high sensitivity to the parameter variations, the deterministic model which neglects the parametric uncertainties is not suitable for practical applications. This paper provides an overview of the key contributions and recent advances in the field of process optimization under uncertainty over the past ten years and discusses their advantages and limitations thoroughly. The discussion is focused on three specific research areas, namely robust optimization, stochastic programming and chance constrained programming, based on which a systematic analysis of their applications, developments and future directions are presented. It shows that the more recent trend has been to integrate different optimization methods to leverage their respective superiority and compensate for their drawbacks. Moreover, data-driven optimization, which combines mathematical programming methods and machine learning algorithms, has become an emerging and competitive tool to handle optimization problems in the presence of uncertainty based on massive historical data. | Ying Chen Zhihong Yuan Bingzhen Chen | 2018 | Chinese Journal of Chemical Engineering2018，26，8： | 5 |
| 5 | A Fuzzy Rough Set Approach to Emergency Material Demand Prediction Over two Universes显示文摘 | Sun Bingzhen Ma Weimin Zhao Haiyan | 2013 | Applied Mathe- matical Modeling2013，37，1011： | 1 |
| 6 | Heterogeneous junctions of magnetic Ni core@binary dielectric shells toward high-efficiency microwave attenuation显示文摘Metal-organic-frameworks(MOFs)derived carbon-based composites with balanced impedance matching and synergistic dielectric/magnetic loss are considered as promising microwave absorbers.With the aim to promote interfacial polarization,herein,heterogeneous junctions composed of magnetic Ni core and binary dielectric shells(C and PEDOT)are synthesized by annealing Ni-MOFs precursors and an in-situ polymerization strategy,forming Ni@C@PEDOT spheres with multilayer heterogeneous interfaces.The results indicate that the final absorption attenuation is sensitive to the thickness of the dielectric PEDOT layer,when the thickness of the PEDOT layer is 224 nm,an optimal reflection loss of-72.4 d B is achieved at 2 mm and the effective absorption bandwidth reaches 6.4 GHz with a thickness of only 1.85 mm,the excellent absorption attenuation is accredited to the promoted impedance matching,enhanced conduction loss as well as the synergistic interfacial polarization induced by magnetic core and binary dielectric shells.Meanwhile,this work offers a simple and significant strategy in preparation for ideal microwave absorbers by rational design of multilayer heterogeneous interfaces. | Jijun Wang Songlin Yu Qingqing Wu Yan Li Fangyuan Li Xiao Zhou Yuhua Chen Bingzhen Li Panbo Liu | 2022 | Journal of Materials Science & Technology2022，，20： | 1 |
| 7 | Rough set theory for the interval-valued fuzzy information systems显示文摘 | Gong Zengtai Sun Bingzhen Chen Degang | 2008 | Information Sciences2008，178，： | 1 |
| 8 | Association of tumor necrosis factor-α gene promoter polymorphisms (-308G/A, -238G/A) with recurrent spontaneous abortion: a meta-analysis显示文摘 | Bingzhen Zhang Tiecheng Liu Zhiping Wang | 2012 | Human Immunology2012，，5： | 1 |
| 9 | Layered diagraph model for HAZOP analysis of chemical processes 显示文摘 | Cui Lin Zhao Jinsong Qiu Tong Chen Bingzhen | 2008 | Process Safety Progress2008，27，4： | 1 |
| 10 | Fuzzy rough set the- ory for the interval-valued fuzzy information systems显示文摘 | Sun Bingzhen Gong Zengtai Chen Degang | 2008 | Informa- tion Sciences2008，178，13： | 1 |
| 11 | Rough set theory for the interval-valued fuzzy information systems显示文摘 | Gong Zengtai Sun Bingzhen Chen Degang | 2008 | Infor- mation Sciences2008，178，： | 1 |
| 12 | Fuzzy rough set theory for the interval-valued fuzzy information sys- tems显示文摘 | Sun Bingzhen Gong Zengtai Chen Degang | 2008 | Information Sciences2008，178，： | 1 |
| 13 | Application of steady-state detection method based on wavelet transform显示文摘 | Jiang Taiwen Chen Bingzhen He Xiaorong | 2003 | Computers and Chemical Engineering2003，27，4： | 1 |
| 14 | A study of the LCA based biofuel supply chain multi-objective opti- mization model with multi-conversion paths in China显示文摘 | Liu Zhexuan Qiu Tong Chen Bingzhen | 2014 | Applied Energy2014，126，： | 1 |
| 15 | Rough set theory for the interval-valued fuzzy information systems显示文摘 | Gong Zengtai Sun Bingzhen Chen Degan | 2008 | Infor?mation Science2008，178，8： | 1 |
| 16 | Instabili- ty of fluid flow and level fluctuation in continuous thin slab casting mould显示文摘 | Shen Bingzhen Shen Houfa Liu Baicheng | 2007 | ISIJ Int2007，47，3： | 1 |
| 17 | Changing patterns of basic household consumption in the Inner Mongolian grasslands : a case study of policy-oriented adoptive changes in the use of grasslands 显示文摘 | DU Bingzhen ZHEN Lin DE GROOT R | 2014 | The Rangeland Journal2014，36，： | 1 |
| 18 | Application of steady-state detection method based on wavelet transform显示文摘 | Taiwen Jiang Bingzhen Chen Xiaorong He Paul Stuart | 2002 | Computers and Chemical Engineering2002，，4： | 1 |
| 19 | Best Mutation Coefficient Genetic Algorithm for ANN Training显示文摘 | Zhou Xiang He Xiaorong Chen Bingzhen | 2002 | Journal of Tsinghua University2002，42，5： | 1 |
| 20 | Applications of Shannon 's entropy theory to naphtha pyrolysis simulation 显示文摘 | ZHANG Lei CHEN Bingzhen | 2012 | Chemical Engineering & Technology2012，35，2： | 1 |
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