| 1 | Chinese herbal medicines for prostate cancer therapy: From experimental research to clinical practice显示文摘Prostate cancer remains the second most common malignancy in men worldwide, is a global health issue,and poses a huge health burden. Precision medicine provides more treatment options for prostate cancer patients, but its popularity, drug resistance, and adverse reactions still need to be focused on. Chinese herbal medicines(CHMs) have been widely accepted as an alternative therapy for cancer, with the advantages of multiple targets, multiple pathways, and low toxicity. We searched the experimental research and clinical practice of CHMs for prostate cancer treatment published in Pub Med, Embase, and Web of Science in the last five years. We found five CHM formulas and six single CHM extracts as well as 12 CHM-derived compounds, which showed induction of apoptosis, autophagy, and cell cycle arrest, suppression of angiogenesis, proliferation, and migration of prostate cancer cells, reversal of drug resistance,and enhancement of anti-tumor immunity. The mechanisms of action include the PI3K/Akt/mTOR, AR,EGFR and Wnt/β-catenin signaling pathways, which are commonly implicated in the development of prostate cancer. We also summarized the advantages of CHMs in patients with hormone-sensitive and castration-resistant prostate cancer and provided ideas for their further experimental design and application. | Fanming Kong Chaoran Wang Jing Zhang Xiaoqun Wang Binxu Sun Xian Xiao Haojian Zhang Yanqi Song Yingjie Jia | 2023 | Chinese Herbal Medicines2023，15，4： | 0 |
| 2 | Traditional Chinese medicines for non-small cell lung cancer: Therapies and mechanisms显示文摘The most common subtype of lung cancer is non-small cell lung cancer(NSCLC), which has a poor prognosis and seriously threatens the health of human beings. The multidisciplinary comprehensive treatment model has gradually become the mainstream of NSCLC treatment. Traditional Chinese medicine(TCM) can be used effectively either as an adjunctive therapy or alone throughout the NSCLC therapy,which has a significant impact on survival, quality of life, and reduction of toxicity. Therefore, this paper reviewed the theoretical basis, the latest clinical application, and combined treatment mechanisms in order to explore the advantage stage of TCM treatment and the synergistic therapeutic mechanisms. | Fanming Kong Chaoran Wang Linlin Zhao Dongying Liao Xiaoqun Wang Binxu Sun Peiying Yang Yingjie Jia | 2023 | Chinese Herbal Medicines2023，15，4： | 0 |
| 3 | Modification Mechanism and Uniaxial Fatigue Performances of A356.2 Alloy Treated by Al-Sr-La Composite Refinement-Modification Agent显示文摘Modification mechanism and uniaxial fatigue properties of A356.2 alloy treated by Al-6Sr-7La and traditional Al-5Ti-1B/Al-10Sr(hereinafter refers to traditional treated alloy) were investigated by constant stress amplitude method. Microstructure, dislocation and Si twinning of the alloys were studied by thermal analysis, scanning electron microscopy(SEM) and transmission electron microscopy(TEM). The results showed that Al-6Sr-7La possesses better refining and modification effect than Al-5Ti-1B/Al-10Sr. Meanwhile, fatigue properties of the alloy treated by Al-6Sr-7La are higher than traditional treated alloy, and this is mainly owing to that Al-6Sr-7La treated alloy has more twins in eutectic Si and lower twin spacing. In addition, higher density of nanophases formed on twin faces and La-rich clusters appear at multiple twin intersections. Stacking faults and entrapped nanophases appeared on growing Si twin faces. Impurity induced twinning(IIT) mechanism and twin plane re-entrant edge(TPRE) mechanism are valid for eutectic Si which are important for mechanical optimization of A356.2 alloy. | Liang Chang Qingfeng Zhao Xingchuan Xia Yuming Ding Binxu Guo Jian Ding Ying Tang Zan Zhang Chong Li Xiaomian Sun Junjie Guo Kaihong Song Yongchang Liu | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员