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| 1 | Esophageal tissue engineering:A new approach for esophageal replacement显示文摘A number of congenital and acquired disorders require esophageal tissue replacement.Various surgical techniques,such as gastric and colonic interposition,are standards of treatment,but frequently complicated by stenosis and other problems.Regenerative medicine approaches facilitate the use of biological constructs to replace or regenerate normal tissue function.We review the literature of esophageal tissue engineering,discuss its implications,compare the methodologies that have been employed and suggest possible directions for the future.Medline,Embase,the Cochrane Library,National Research Register and ClinicalTrials.gov databases were searched with the following search terms:stem cell and esophagus,esophageal replacement,esophageal tissue engineering,esophageal substitution.Reference lists of papers identified were also examined and experts in this field contacted for further information.All full-text articles in English of all potentially relevant abstracts were reviewed.Tissue engineering has involved acellular scaffolds that were either transplanted with the aim of being repopulated by host cells or seeded prior to transplantation.When acellular scaffolds were used to replace patch and short tubular defects they allowed epithelial and partial muscular migration whereas when employed for long tubular defects the results were poor leading to an increased rate of stenosis and mortality.Stenting has been shown as an effective means to reduce stenotic changes and promote cell migration,whilst omental wrapping to induce vascularization of the construct has an uncertain benefit.Decellularized matrices have been recently suggested as the optimal choice for scaffolds,but smart polymers that will incorporate signalling to promote cell-scaffold interaction may provide a more reproducible and available solution.Results in animal models that have used seeded scaffolds strongly suggest that seeding of both muscle and epithelial cells on scaffolds prior to implantation is a prerequisite for complete esophageal replacement.Novel approaches need to be designed to allow for peristalsis and vascularization in the engineered esophagus.Although esophageal tissue engineering potentially offers a real alternative to conventional treatments for severe esophageal disease,important barriers remain that need to be addressed. | Giorgia Totonelli Panagiotis Maghsoudlou Jonathan M Fishman Giuseppe Orlando Tahera Ansari Paul Sibbons Martin A Birchall Agostino Pierro Simon Eaton Paolo De Coppi | 2012 | World Journal of Gastroenterology2012，18，47： | 5 |
| 2 | Copolymerization of peptide derived monomers and methyl methacrylate 显示文摘 | Birchall A C Bush S M Noah M | 2001 | Polymer2001，42，： | 1 |
| 3 | Copolymerization of peptide derived monomers and methyl methacrylate显示文摘 | A C Birchall S M Bush M North | | 0，，2： | 1 |
| 4 | Laryngectomees' views on laryngeal transplantation显示文摘 | POTTER C P BIRCHALL M A | 1998 | Transpl Int1998，11，： | 1 |
| 5 | Copolymerization of peptide derived monomers and methyl methacrylate 显示文摘 | Birchall A C Bush S M North M | 2001 | Polymer2001，42，： | 1 |
| 6 | Laryngeal abductor mus- cle relnnervation in a pig mode显示文摘 | Birchall M Idowu B Jones A | 2004 | Acta Otolaryngol2004，124，： | 1 |
| 7 | Clinical transplantation of a tissue-engineered airway显示文摘 | Paolo Macchiarini Philipp Jungebluth Tetsuhiko Go M Adelaide Asnaghi Louisa E Rees Tristan A Cogan Amanda Dodson Jaume Martorell Silvia Bellini Pier Paolo Parnigotto Sally C Dickinson Anthony P Hollander Sara Mantero Maria Teresa Conconi Martin A Birchall | 2008 | The Lancet2008，，9655： | 1 |
| 8 | Airway tissue engineering显示文摘 | Jonathan M Fishman Paolo De Coppi Martin J Elliott Anthony Atala Martin A Birchall Paolo Macchiarini | 2011 | Expert Opinion on Biological Therapy2011，，12： | 1 |
| 9 | A preclinical model for laryngeal transplantation:anatomy and mucosal immunology of the porcine larynx显示文摘 | GORTI G K BIRCHALL M A HAVERSON K | 1999 | Transplantation1999，68，： | 1 |
| 10 | Laryngeal transplantation in 2005:a review显示文摘 | BIRCHALL M A LORENZ R R BERKE G S | 2006 | Am J Transplant2006，6，1： | 1 |
| 11 | Laryngeal transplantation in 2005:a review显示文摘 | BIRCHALL M A LORENZ R R BERKE G S | 2006 | Am J Transplant2006，6，1： | 1 |
| 12 | Recurrence and malig-nant degeneration of 89 cases of inverted papilloma diagnosed in a non-tertiary referral population between 1975 and 1995:clinical predictors and p53 studies显示文摘 | Jardine A H Davies G R Birchall M A | 2000 | Clin Otolaryngol Allied Sci2000，25，： | 1 |
| 13 | Racial differences in nasal fossa dimensions determined by acoustic rhinometry显示文摘 | Morgan N J MacGregor F B Birchall M A | 1995 | Rhinology1995，33，4： | 1 |
| 14 | Laryngeal transplantation in 2005:a review显示文摘 | Birchall M A Lorenz R R Berke G S | 2006 | Am J Transplant2006，6，1： | 1 |
| 15 | Primary CD4+ T- cell responses provide both helper and cytotoxic functions during Epstein-Barr virus infection and transformation of fetal cord blood B cells显示文摘 | Macarthur G J Wilson A D Birchall M A | 2007 | J Virol2007，81，9： | 1 |
| 16 | Laryngeal transplantation in 2005:a review显示文摘 | Birchall M A Lorenz R R Berke G S | 2006 | Am J Transplant2006，6，1： | 1 |
| 17 | Laryngeal reinnervation for bilateral vocal fold paralysis显示文摘 | Marina M B Marie J P Birchall M A | 2011 | Curr Opin Otolaryngol Head Neck Surg2011，19，6： | 1 |
| 18 | Morphometry of paranasal sinus anatomy in chronic rhinosinusitis: a pilot study显示文摘 | Birchall M A Amstrong S J | 1998 | Arch Otolaryngol Head Neck Surg1998，124，6： | 1 |
| 19 | 组织工程气管临床移植显示文摘背景失去正常气道会造成灾难性的后果,而大气道置换的各种尝试均遇到严重问题,组织工程气管置换的先决条件是该组织工程材料必须具备合适的基质、细胞、理想的机械性能而且无抗原性。本文中,作者旨在利用组织工程的原理和技术,通过生物工程气管基质的临床应用,评估该技术在一例患有终末期气道疾病患者中的应用情况。方法通过特定的技术去除供体一段气管的细胞和主要组织相容性复合体(MHC)抗原,将来源于受体(一名30岁患有终末期支气管软化的女性患者)的上皮细胞和间充质干细胞源性软骨细胞经细胞培养后种植于该段移植物基质中,然后用该移植物置换受体的左主支气管。结果术后该移植物立即建立了功能性气道,患者的生活质量得到了改善,在术后4个月时该段气管外观和机械性能保持正常,患者未产生抗供体的抗体,也未接受任何抗排异药物治疗。结论结果表明,该生物组织工程气管具有良好的机械性能,具备气管的正常功能,并且无免疫排异反应。这一结果提示自体细胞与适当生物材料结合的移植物可成功治疗某些严重的临床疾病。 | Paolo Macchiarini Philipp Jungebluth Tetsuhiko Go M Adelaide Asnaghi Louisa E Rees Tristan A Cogan Amanda Dodson Jaume Martorell Silvia Bellini Pier Paola Pamigotto Sally C Dickinson Anthony P Hollander Sara Mantero Maria Teresa Conconi Martin A Birchall 哈肖别克·卡斯木(译) | 2009 | 世界临床医学2009，3，2： | 0 |
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