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| 1 | 屋尘螨脱敏治疗对变应性鼻炎及哮喘患者血清粉尘螨特异性IgG_4抗体的影响显示文摘目的探讨屋尘螨特异性免疫治疗对血清屋尘螨和粉尘螨特异性IgG_4水平的影响。方法32例接受安脱达屋尘螨特异性免疫治疗4~14个月的变应性鼻炎和支气管哮喘患者,抽取其治疗前后血清共64份。采用四层双抗夹心酶联免疫吸附法测定患者血清特异性IgG_4抗体。结果脱敏治疗后的患者血清中屋尘螨和粉尘螨特异性IgG_4抗体水平均有显著上升(P<0.0001),且IgG_4抗体的增长水平与治疗时间呈正相关。结论使用屋尘螨脱敏疫苗治疗所产生的IgG_4抗体能同时识别屋尘螨和粉尘螨两种抗原,从而使机体产生对这两种致敏原的免疫保护作用。 | 肖晓雄 黄东明 崔碧云 赖旭新 Birgitte Gjesing Michael Spangfort 钟南山 | 2009 | 中华临床免疫和变态反应杂志2009，3，1： | 38 |
| 2 | Indoor Allergen Levels and Household Distributions in Nine Cities Across China显示文摘Objective Chinese allergic subjects have high levels of sensitization to house dust mite(HDM) and other indoor allergens. This study quantifies common indoor allergen levels in Chinese households. Methods Dust samples were collected from nine cities. Major allergens Der p 1 and Der f 1 from Dermatophagoides pteronyssinus and D. farinae, and specific antigens of Blomia tropicalis, Tyrophagus putrescentiae, Acarus siro, and cockroach species Blattella germanica and Periplaneta americana were measured by ELISA. Results HDM allergens were found in dust samples from bedding in 95% of the Chinese households. The median levels varied from <0.006 to 9.2 μg/g of dust, depending on the city. The percentages of households having HDM allergen levels associated with the risk of developing allergy sensitization and asthma were 65% and 25%, respectively. Specific antigens of the storage mite and cockroach were only found in samples from the southern and tropical regions of China. Levels of mite allergens were generally higher in samples from bedding compared to samples from the living room, even for storage mites, whereas levels of cockroach antigens were higher in the living room samples. Conclusion HDM allergens are present in bedding dust samples from most Chinese households. Cities in southern and central China have relatively high levels of HDM major allergens compared to cities in northern and western China. Antigens of storage mites and cockroaches are not as common as HDM allergens. | ZHENG Yi Wu LAI Xu Xin ZHAO De Yu ZHANG Chun Qing CHEN Jian Jun ZHANG Luo WEI Qing Yu CHEN Shi LIU En Mei NORBACK Dan GJESING Birgitte ZHONG Nan Shan SPANGFORT D.Michael | 2015 | Biomedical and Environmental Sciences2015，28，10： | 24 |
| 3 | 海南变态反应性疾病患儿对屋尘螨/粉尘螨和仓储螨的特异性IgE显示文摘目的探讨海南变态反应性疾病患儿对尘螨和仓储螨的特异性IgE水平。方法对海南变态反应性疾病患儿进行13种常见变应原皮肤点刺和7种螨的体外特异性IgE检测。结果 121例患儿中对屋尘螨和粉尘螨的皮肤点刺阳性率为100%,而对热带无爪螨的阳性率为85.8%。7种螨的体外特异性IgE依次为屋尘螨99.2%、粉尘螨95.0%、热带无爪螨87.6%、家嗜甜螨79.7%、害嗜鳞螨67.8%、腐食酪螨59.5%和粗脚粉螨52.9%。对仓储螨过敏的患儿同时都对屋尘螨和热带无爪螨过敏,并且IgE水平更高。除热带无爪螨外,其他仓储螨的特异性IgE有很好的相关性。结论除屋尘螨和粉尘螨外,热带无爪螨也是海南地区的重要致敏原,其他仓储螨亦有可能引起慢性变态反应性疾病。 | 陈实 郑轶武 王灵 陈冰 林小珍 Birgitte Gjesing 钟南山 Michael D.Spangfort | 2010 | 中华临床免疫和变态反应杂志2010，4，3： | 20 |
| 4 | Allergen micro-array detection of specific IgE-reactivity in Chinese allergy patients显示文摘背景变应原微数组是为浆液 IgE-reactivity.In 屏蔽这学习变应原的强大的工具微数组被用来鉴别在选择中国过敏症 patients.Methods 之中统治IgE有约束力的变应原和跨反应的模式学习从广州的城市用耐心的 sera 被进行,南京,有 Dermatophagoides pteronyssinus ( Der p )的 Chengdu 和 Shenyang.In 总数 100 sera 比 50 kU/L 高的特定的IgE水平为对 103 | ZHENG Yi-wu LI Jing LAI Xu-xin ZHAO De-yu LIU Xiao-fan LIN Xiao-ping Birgitte Gjesing Paola Palazzo Adriano Mari ZHONG Nan-shan Michael D Spangfort | 2011 | Chinese Medical Journal2011，，24： | 16 |
| 5 | Prevalence of sensitization to weed pollens of Humulus scandens,Artemisia vulgaris,and Ambrosia artemisiifolia in northern China显示文摘Objective:Weed pollens are common sources of allergens worldwide.The prevalence of weed pollen sensitization is not yet fully known in China.The purpose of this study was to investigate the prevalence of sensitization to weed allergens from Artemisia,Ambrosia,and Humulus in northern China.Methods:A total of 1144 subjects(aged from 5 to 68 years) visiting our clinic from June to October 2011 underwent intradermal testing using a panel of 25 allergen sources.Subjects with positive skin responses to any pollen were further tested for their serum concentrations of IgE antibodies against Artemisia vulgaris,Ambrosia artemisiifolia,and Humulus scandens,and against the purified allergens,Art v 1 and Amb a 1.Results:Of 1144 subjects,170 had positive intradermal reactions to pollen and 144 donated serum for IgE testing.The prevalence of positive intradermal responses to pollens of Artemisia sieversiana,Artemisia annua,A.artemisiifolia,and H.scandens was 11.0%,10.2%,3.7%,and 6.6%,respectively.Among the intradermal positive subjects,the prevalence of specific IgE antigens to A.vulgaris was 58.3%,to A.artemisiifolia 14.7%,and to H.scandens 41.0%.The prevalence of specific IgE antigens to the allergen Art v 1 was 46.9%,and to Amb a 1 was 11.2%.The correlation between the presence of IgE antibodies specific to A.vulgaris and to the Art v 1 antigen was very high.Subjects with A.artemisiifolia specific IgE also had A.vulgaris specific IgE,but with relatively high levels of A.vulgaris IgE antibodies.There were no correlations between the presence of IgE antibodies to H.scandens and A.vulgaris or to H.scandens and A.artemisiifolia.Conclusions:The intradermal prevalence of weed pollen sensitization among allergic subjects in northern China is about 13.5%.Correlations of specific IgE antibodies suggest that pollen allergens from Artemisia and Humulus are independent sources for primary sensitization. | Guo-dong HAO Yi-wu ZHENG Birgitte GJESING Xing-ai KONG Jing-yuan WANG Zhi-jing SONG Xu-xin LAI Nan-shan ZHONG Michael D.SPANGFORT | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，3： | 5 |
| 6 | Prevalence of sensitivity to cockroach allergens and IgE crossreactivity between cockroach and house dust mite allergens in Chinese patients with allergic rhinitis and asthma显示文摘背景蟑螂是引起过敏鼻炎和气喘的重要室内的变应原来源。这研究的目的是在中国的大陆调查蟑螂流行并且在在蟑螂促进感受性模式基于的中国 patients.Methods 的蟑螂和皮肤刺测试( SPT )从国家 multicenter 流行研究获得了的房子灰尘螨变应原之间的 IgE 跨反应,在哪个从越过参与的中国的 25 个过敏症中心的 6304 个病人。在美国、德国的蟑螂和房子灰尘螨 Der p 之间的因素,中国的包括的不同区域,年龄,性和关联被调查。十八从从华南的 1236 临床的 sera 被选择完全执行在房子灰尘螨和 cockroaches.Results 之间的跨抑制的试金 25.7% 病人是对美国蟑螂积极的 SPT (Periplaneta 有关美国的史料,每一) 并且对德国蟑螂积极的 18.7% SPT (Blattella germanica, Bla g ) 。积极蟑螂 SPT 的流行是更高的在比在北中国南部,在成年人更高比在孩子,并且更高在男性比在相对有的 females.Patients 蟑螂 SPT 反应的底层,主要班 1 或 2。SPT 积极蟑螂病人, 88% 也是对房子灰尘螨积极的 SPT (Dermatophagoides pteronyssinus, Der p ) 。IgE 跨抑制的研究证实 Der P 促进感受性能对蟑螂敏感的相对高的流行在中国的大陆被发现的 cockroach.Conclusions 引起假积极 SPT 反应。然而,跨抑制的研究证明仅仅病人的一个小号码看起来有 Bla g 或每同样主要的敏化来源。为在中国的大陆的过敏症状的促进感受性和扳机的一个风险因素需要进一步被调查的蟑螂的重要性。 | SUN Bao-qing LAI Xu-xin Birgitte Gjesing Michael Dho Spangfort ZHONG Nan-shan | 2010 | Chinese Medical Journal2010，，24： | 5 |
| 7 | Indoor mite allergen levels, specific IgE prevalence and IgE cross-inhibition pattern among asthmatic children in Haikou, southern China显示文摘 | ZHENG Yi-wu CHEN Shi LAI Xu-xin Birgitte Gjesing ZHONG Nan-shan Michael D Spangfort | 2012 | Chinese Medical Journal2012，，17： | 3 |
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