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| 1 | Italian survey on non-steroidal anti-inflammatory drugsand gastrointestinal bleeding in children显示文摘AIM: To investigate gastrointestinal complications associated with non-steroidal anti-inflammatory drug(NSAIDs) use in children.METHODS: A retrospective, multicenter study was conducted between January 2005 and January 2013, with the participation of 8 Italian pediatric gastroenterology centers. We collected all the cases of patients who refer to emergency room for suspected gastrointestinal bleeding following NSAIDs consumption, and underwent endoscopic evaluation. Previous medical history, associated risk factors, symptoms and signs at presentation, diagnostic procedures, severity of bleeding and management of gastrointestinal bleeding were collected. In addition, data regarding type of drug used, indication, dose, duration of treatment and prescriber(physician or selfmedication) were examined. RESULTS: Fifty-one patients, including 34 males, were enrolled(median age: 7.8 years). Ibuprofen was the most used NSAID [35/51 patients(68.6%)]. Pain was the most frequent indication for NSAIDs use [29/51 patients(56.9%)]. Seven patients had positive family history of Helicobacter pylori(H. pylori) infection or peptic ulcer, and 12 had associated comorbidities. Twenty-four(47%) out of 51 patients used medication inappropriately. Hematemesis was the most frequent symptom(33.3%). Upper gastrointestinal endoscopy revealed gastric lesions in 32/51(62%) patients, duodenal lesions in 17(33%) and esophageal lesions in 8(15%). In 10/51(19.6%) patients, a diagnosis of H. pylori gastritis was made. Forty-eight(94%) patients underwent medical therapy, with spontaneous bleeding resolution, while in 3/51(6%) patients, an endoscopic hemostasis was needed.CONCLUSION: The data collected in this study confirms that adverse events with the involvement of the gastrointestinal tract secondary to NSAID use are also common in | Sabrina Cardile Massimo Martinelli Arrigo Barabino Paolo Gandullia Salvatore Oliva Giovanni Di Nardo Luigi Dall'Oglio Francesca Rea Gian Luigi de'Angelis Barbara Bizzarri Graziella Guariso Enzo Masci Annamaria Staiano Erasmo Miele Claudio Romano | 2016 | World Journal of Gastroenterology2016，22，5： | 7 |
| 2 | Short- and long-term efficacy of endoscopic balloon dilation in Crohn's disease strictures显示文摘AIM:To evaluate short- and long-term efficacy of endoscopic balloon dilation in a cohort of consecutive patients with symptomatic Crohn's disease (CD)-related strictures. METHODS:Twenty-six CD patients (11 men; median age 36.8 year, range 11-65 years) with 27 symptomatic strictures underwent endoscopic balloon dilation (EBD).Both naive and post-operative strictures, of any length and diameter, with or without associated fistula were included. After a clinical and radiological assessment, EBD was performed with a Microvasive Rigiflex through the scope balloon system. The procedure was considered successful if no symptom reoccurred in the following 6 mo. The long-term clinical outcome was to avoid surgery. RESULTS:The mean follow-up time was 40.7 ± 5.7 mo (range 10-94 mo). In this period, forty-six EBD were performed with a technical success of 100%. No procedure-related complication was reported. Surgery was avoided in 92.6% of the patients during the entire follow-up. Two patients, both presenting ileocecal strictures associated with fistula, failed to respond to the treatment and underwent surgical strictures resection. Of the 24 patients who did not undergo surgery, 11 patients received 1 EBD, and 13 required further dilations over time for the treatment of relapsing strictures (7 patients underwent 2 dilations, 5 patients 3 dilations, and 1 patient 4 dilations). Overall, the EBD success rate after the first dilation was 81.5%. No difference was observed between the EBD success rate for naive (n = 12) and post-operative (n = 15) CD related strictures (P > 0.05). CONCLUSION:EBD appears to be a safe and effective procedure in the therapeutic management of CD-related strictures of any origin and dimension in order to prevent surgery. | Nicola de'Angelis Maria Clotilde Carra Osvaldo Borrelli Barbara Bizzarri Francesca Vincenzi Fabiola Fornaroli Giuseppina De Caro Gian Luigi de'Angelis | 2013 | World Journal of Gastroenterology2013，19，17： | 4 |
| 3 | Solid phase extraction and high performance liquid chromatographic determination of doxophylline in plasma显示文摘 | Lagana A Bizzarri M Marino A | 1990 | Biomed Chromatogr1990，4，5： | 2 |
| 4 | Helicobacter pylori Infection in Clinical Practice: Probiotics and a Combination of Probiotics?+?Lactoferrin Improve Compliance, But Not Eradication, in Sequential Therapy显示文摘 | Marco Manfredi Barbara Bizzarri Roberto Igino Sacchero Sergio Maccari Lorenzo Calabrese Fabio Fabbian Gian Luigi de’Angelis | 2012 | Helicobacter2012，，4： | 2 |
| 5 | Helicobacter pylori Infection: Sequential Therapy Followed by Levofloxacin‐Containing Triple Therapy provides a Good Cumulative Eradication Rate显示文摘 | Marco Manfredi Barbara Bizzarri Gian Luigi de’Angelis | 2012 | Helicobacter2012，，4： | 2 |
| 6 | Helicobacter pylori Infection in Clinical Practice: Probiotics and a Combination of Probiotics?+?Lactoferrin Improve Compliance, But Not Eradication, in Sequential Therapy显示文摘 | Marco Manfredi Barbara Bizzarri Roberto Igino Sacchero Sergio Maccari Lorenzo Calabrese Fabio Fabbian Gian Luigi de’Angelis | 2012 | Helicobacter2012，，4： | 2 |
| 7 | ELR + CXC chemokines and their receptors (CXC chemokine receptor 1 and CXC chemokine receptor 2) as new therapeutic targets显示文摘 | Cinzia Bizzarri Andrea Rosario Beccari Riccardo Bertini Michela Rita Cavicchia Simona Giorgini Marcello Allegretti | 2006 | Pharmacology and Therapeutics2006，，1： | 2 |
| 8 | Hepatocellular carcinoma: long-term results of combined treatment with laser thermal ablation and transcatheter arterial chemoembolization 显示文摘 | Paeella CM Bizzarri G Cecconi P | 2001 | Radiology2001，219，3： | 1 |
| 9 | Release of transforming growth factor beta-1 in a vestibular schwannoma cell line显示文摘 | Filipo R Valente MG | 2002 | Acta Otolaryngol2002，122，7： | 1 |
| 10 | Percutaneous Laser Ablation in the Treatment of Hepatocellular Carcinoma with Small Tumors: Analysis of Factors Affecting the Achievement of Tumor Necrosis显示文摘 | Claudio Maurizio Pacella Giancarlo Bizzarri Giampiero Francica Antonio Bianchini Stefano De Nuntis Sara Pacella Anna Crescenzi Silvia Taccogna Giuseppe Forlini Zaccaria Rossi John Osborn Roberto Stasi | 2005 | Journal of Vascular and Interventional Radiology2005，，11： | 1 |
| 11 | Autoimmune thyroid diseases in children显示文摘 | Cappa M Bizzarri C Crea F | | 0，，： | 1 |
| 12 | Thyroid tissue: US-guided percutaneous laser thermal ablation显示文摘 | Pacella CM Bizzarri Spiezia S et ol | 2004 | Radiology2004，232，1： | 1 |
| 13 | Hepatocelluar carcinoma:long term result of combined treatment with laser thermal ablation and transcatheter arterial chemoembolization显示文摘 | PACELLA C M BIZZARRI G CECCONI P | 2001 | Radiology2001，219，3： | 1 |
| 14 | ELR~h CXC chemokinesand their receptors (CXC chemokine receptor 1 and CXC chemo-kine receptor 2) as new therapeutic targets显示文摘 | Bizzarri C Beccari AR Bertini R | 2006 | Pharmacol Ther2006，112，1： | 1 |
| 15 | Thyroid tissue:US-guided percutaneous laser thermal ablation显示文摘 | PACELLA C M BIZZARRI G SPIEZIA S | 2004 | Radiology2004，232，1： | 1 |
| 16 | Endoscopic placement of video capsule in a pediatric population显示文摘 | Barbara Bizzarri Fabiola Fornaroli | 2005 | Gastrointestinal Endoscopy2005，，6： | 1 |
| 17 | Treatment of benign cold thyroid nodules: A randomized clinical trial of percutaneous la- ser-ablation versus levothyroxine therapy or follow-up显示文摘 | Papini E Guglielmi R Bizzarri G | 2007 | Thyr- oid2007，17，3： | 1 |
| 18 | Early onset sepsis in very low birth weight newborn infants显示文摘 | Pisani V Bizzarri B Cardi V | | 0，，3： | 1 |
| 19 | The response to gonadotro- pin releasing hormone (GnRH) stimulation test does not predict the progression to true precocious puberty in girls with onset of premature thelarche in the first three years of life显示文摘 | Bizzarri C Spadoni GL Bottaro G | 2014 | J Clin Endocrinol Metab2014，99，2： | 1 |
| 20 | Early onset sepsis in very low birth weight newborn infants 显示文摘 | Pisani V Bizzarri B Cardi V | 2012 | J Matem Fetal Neonatal Med2012，253，： | 1 |
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