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| 1 | Diagnostic and prognostic value of circulating micro RNAs in heart failure with preserved and reduced ejection fraction显示文摘micro RNAs(mi RNAs) are powerful regulators of posttranscriptional gene expression and play an important role in pathophysiological processes. Circulating mi RNAs can be quantified in body liquids and are promising biomarkers in numerous diseases. In cardiovascular disease mi RNAs have been proven to be reliable diagnostic biomarkers for different disease entities. In cardiac fibrosis(CF) and heart failure(HF) dysregulated circulating mi RNAs have been identified,indicating their promising applicability as diagnostic biomarkers. Some mi RNAs were successfully tested in risk stratification of HF implementing their potential use as prognostic biomarkers. In this respect mi RNAs might soon be implemented in diagnostic clinical routine. In the young field of mi RNA based research advances have been made in identifying mi RNAs as potential targets for the treatment of experimental CF and HF. Promising study results suggest their potential future application as therapeutic agents in treatment of cardiovascular disease. This article summarizes the current state of the various aspects of mi RNA research in the field of CF and HF with reduced ejection fraction as well as preserved ejection fraction. The review provides an overview of the application of circulating mi RNAs as biomarkers in CF and HF and current approaches to therapeutically utilize mi RNAs in this field of cardiovascular disease. | Christian Schulte Dirk Westermann Stefan Blankenberg Tanja Zeller | 2015 | World Journal of Cardiology2015，7，12： | 11 |
| 2 | D-二聚体预测稳定型冠状动脉性心脏病患者的长期病因特异性死亡率、心血管事件和癌症显示文摘交联纤维蛋白的降解产物D-二聚体是高凝状态和血栓形成事件的标志。D-二聚体水平中度升高与血管疾病患者静脉和动脉事件的风险相关。在缺血性疾病长期普伐他汀干预(long-term intervention with pravastatin in ischemic disease,LIPID)试验中,研究者在存在其他危险因素的背景下,评估了D-二聚体水平在预测长期血管转归、病因特异性死亡率和新发癌症中的作用。 | 刘青 叶鹏 Simes J Robledo KP White HD Espinoza D Stewart RA Sullivan DR Zeller T Hague W Nestel PJ Glasziou PP Keech AC Elliott J Blankenberg S Tonkin AM LIPID study investigators | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 3 | Challenging aspects of treatment strategies in heart failure with preserved ejection fraction: “Why did recent clinical trials fail?”显示文摘Heart failure(HF) is the leading cause of hospitalization among older adults and the prevalence is growing with the aging populations in the Western countries. Epidemiologic reports suggest that approximately 50% of patients who have signs or symptoms of HF have preserved left ventricular ejection fraction. This HF type predominantly affects women and the elderly with other co-morbidities, such as diabetes, hypertension, and overt volume status. Most of the current treatment strategies are based on morbidity benefits such as quality of life and reduction of clinical HF symptoms. Treatment of patients with HF with preserved ejection fraction displayed disappointing results from several large randomized controlled trials. The heterogeneity of HF with preserved ejection fraction, understood as complex syndrome, seems to be one of the primary reasons. Here, we present an overview of the current management strategies with available evidence and new therapeutic approach from drugs currently in clinical trials, which target diastolic dysfunction, chronotropic incompetence, and risk factor management. We provide an outline and interpretation of recent clinical trials that failed to improve outcome and survival in patients with HF with preserved ejection fraction. | Peter Moritz Becher Nina Fluschnik Stefan Blankenberg Dirk Westermann | 2015 | World Journal of Cardiology2015，7，9： | 3 |
| 4 | Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease显示文摘 | Christoph Bickel Hans J Rupprecht Stefan Blankenberg Gerd Rippin Gerd Hafner Alexander Daunhauer Klaus-Peter Hofmann Jürgen Meyer | 2002 | The American Journal of Cardiology2002，，1： | 2 |
| 5 | ST2可能并非心血管事件、心力衰竭和死亡有用的预测因子显示文摘研究人员假设可溶性ST2(soluble ST2,sST2)水平可识别出心血管疾病(cardiovascular disease,CVD)风险较高的人群,应将其纳入风险预测计算指标。ST2是炎症性细胞因子白细胞介素33的受体。sST2水平增加与急性心肌梗死患者和一般人群的心力衰竭及死亡相关。方法:研究人员测定FINRISK97前瞻性研究人群队列中的8444名男性和女性(25-74岁)的高敏sST2水平,应用Cox比例风险模型评估在15年的随访中,sST2对致命性或非致命性心力衰竭、CVD(冠状动脉性心脏病和脑卒中)、糖尿病和死亡情况的预测能力。研究者获取10年绝对风险识别和重新分类的统计数据, | 赵狄 叶鹏 Hughes MF Appelbaum S Havulinna AS Jagodzinski A Zeller T2 Kee F Blankenberg S Salomaa V | 2014 | 中华高血压杂志2014，22，8： | 2 |
| 6 | Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease显示文摘 | Blankenberg S Rupprecht HJ Poirier O | 2003 | Circulation2003，107，12： | 1 |
| 7 | Interleukin18 and the risk of coronary heart disease in European men: the Prospective Epidemiological Study of Myoc-ard ial Intaretion (PRIME) 显示文摘 | Blankenberg S Luc G Ducimetiere P | 2003 | Circulation2003，108，20： | 1 |
| 8 | Serum uric acid asan independent predictor of mor-tality in patients with angiographically proven coronary artery diseasel显示文摘 | Bickel C Rupprecht HJ Blankenberg S | 2002 | Am J Cardiol2002，89，： | 1 |
| 9 | Serum ttric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease显示文摘 | Bickel C Rupprecht HJ Blankenberg S | 2002 | Am J Cardiol2002，89，1： | 1 |
| 10 | Plas- ma concentrations and genetic variation of matrix metallopro- teinase 9 and prognosis of patients with cardiovascular disease 显示文摘 | BLANKENBERG S RUPPRECHT HJ POIRIER O | 2003 | Circulation2003，107，12： | 1 |
| 11 | Asymmetric dime-thylarginine and the risk of cardiovascular events and death in patients with coronary artery disease:results from the Athero-Gene Study显示文摘 | Schnabel R Blankenberg S Lubos E | 2005 | Circ Res2005，97，： | 1 |
| 12 | Plasma concentrations and genetic variation of atrix metalloproteinase 9 and prognosis of patients with cardiovascular disease显示文摘 | Blankenberg S Rupprecht H Poiriero | 2003 | Circulation2003，107，： | 1 |
| 13 | Asymmetric dimethylarginine and the risk of cardiovascular events and death in patients with coronary artery disease: results from the AtheroGene Study 显示文摘 | Schnabel R Blankenberg S Lubos E | 2005 | Circ Res2005，97，8： | 1 |
| 14 | Noninvasive assessment of tumor VEGF receptors in response to treatment with pazopanib:a molecular imaging study显示文摘 | Blankenberg FG Levashova Z Sarkar SK | 2010 | Transl Oncol2010，3，1： | 1 |
| 15 | The role of Inflammation and infection in acute coronary syndrome显示文摘 | Blankenberg S Rupprecht HJ Bikel C | 2001 | Herz2001，26，1： | 1 |
| 16 | Relation of m arkers of inflammation ( C - reactive protein, fibrinogen, yen Willebr and factor, and Leukocyte count) and statin therapy to long - term mortality in patients with angiographically proven coronary artery disease 显示文摘 | BICKEL C RUPPRECHT H J BLANKENBERG S | 2002 | Am J Cardiol2002，89，8： | 1 |
| 17 | Relation of markers of inflammation(C-reactive protein,fibrinogen,von Willebrandfactor,and leukocyte count)and statin therapy to long-term mortality in patients with angiographically proven coronary artery disease显示文摘 | Bickel C Rupprecht HJ Blankenberg S | 2002 | Am JCardiol2002，89，8： | 1 |
| 18 | Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease 显示文摘 | Bickel C Rupprecht HJ Blankenberg S | 2002 | Am J Cardiol2002，89，1： | 1 |
| 19 | Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease显示文摘 | Bickel C Rupprecht H J Blankenberg S | 2002 | Am J Cardiol2002，89，1： | 1 |
| 20 | Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease显示文摘 | Bickel C Rupprecht H J Blankenberg | 2002 | Am J Cardiol2002，89，1： | 1 |
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