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| 1 | Bacterial biota in reflux esophagitis and Barrett's esophagus显示文摘AIM: To identify the bacterial flora in conditions such as Barrett's esophagus and reflux esophagitis to determine if they are similar to normal esophageal flora.METHODS: Using broad-range 16S rDNA PCR,esophageal biopsies were examined from 24 patients [9with normal esophageal mucosa, 12 with gastroesophageal reflux disease (GERD), and 3 with Barrett's esophagus].Two separate broad-range PCR reactions were performed for each patient, and the resulting products were cloned.In one patient with Barrett's esophagus, g9 PCR clones were analyzed.RESULTS: Two separate clones were recovered from each patient (total = 48), representing 24 different species, with 14 species homologous to known bacteria,5 homologous to unidentified bacteria, and 5 were not homologous (<97% identity) to any known bacterial 16S rDNA sequences. Seventeen species were found in the reflux esophagitis patients, 5 in the Barrett's esophagus patients, and 10 in normal esophagus patients.Further analysis concentrating on a single biopsy from an individual with Barrett's esophagus revealed the presence of 21. distinct bacterial species. Members of four phyla were represented, including Bacteroidetes,Firmicutes, Proteobacteria, and Actinobacteria.Microscopic examination of each biopsy demonstrated bacteria in intimate association with the distal esophageal epithelium, suggesting that the presence of these bacteria is not transitory.CONCLUSION: These findings provide evidence for a complex, residential bacterial population in esophageal reflux-related disorders. While much of this biota is present in the normal esophagus, more detailed comparisons may help identify potential disease associations. | Zhiheng Pei Liying Yang Richard M Peek Jr Steven M Levine David T Pride Martin J Blaser | 2005 | World Journal of Gastroenterology2005，11，46： | 11 |
| 2 | Radiation use effi- ciency in dual winter cereal forage production systems 显示文摘 | Singer J W Sauer T J Blaser B C | 2007 | Agronomy Journal2007，99，4： | 1 |
| 3 | STEP(satellite test of the equivalence principle)显示文摘 | Sumner T J Anderson J Blaser J P Cruise A M Damour T Dittus D Everitt C W F Fou-lon B Jafry Y Kent B J Lockerbie N Loeffler F Mann G Mester J Pegrum C ReinhardtR Sandford M Scheicher A Speake C C Torii R Theil S Touboul P Vitale S Vodel W Worden P W | 2007 | Advance in Space Re-search2007，39，2： | 1 |
| 4 | 查看详情显示文摘 | Blaser H.-U Burkhardt S Kimer H.J M(o)ssner T Studer M | | 0，，： | 1 |
| 5 | Helicobacter pylori:A bacterial cause of gastritis,peptic ulcer disease,and gastric cancer 显示文摘 | Cover T L Blaser M J | 1995 | American Society for Microbiology News1995，61，： | 1 |
| 6 | Cloning and expression of a high molecular 2 mass major antigen of helicobacter pylori evidence of linkage to cytotoxin production显示文摘 | COVER T L BLASER M J | 1993 | Infect Immune1993，6，15： | 1 |
| 7 | Purification and characterization of the vacuolating toxin from Helicobacter pylori 显示文摘 | Cover T L Blaser M J | 1992 | The Journal of Biological Chemistry1992，267，10： | 1 |
| 8 | Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production 显示文摘 | TUMMURU M K R COVER T L BLASER M J | 1993 | Infect lmmun1993，61，5： | 1 |
| 9 | Risk of stroke,transient ischemic attack,and vessel occlusion before endar-terectomy in patients with symptomatic severe carotid steno-sis显示文摘 | Blaser T Hofmann K Buerger T | 2002 | Stroke2002，33，： | 1 |
| 10 | Use of an open- reading frame-specific Campylobacterjejuni DNA microarray as a new genotyping tool for studying epidemiologically related isolates 显示文摘 | Leonard II EE Takata T Blaser MJ | 2003 | J Infect Dis2003，187，4： | 1 |
| 11 | Risk of stroke, transient ischemic attack, and vessel occlusion before endarterectomy in patients with symptomatic severe carotid stencils 显示文摘 | Blaser T Hofmann K Buerger T | 2002 | Stroke2002，33，： | 1 |
| 12 | Risk of stroke, transient ischemic attack, and vessel occlusion before endarterectomy in patients with symptomatic severe carotid stenosis 显示文摘 | Blaser T Hofmann K Buerger T | 2002 | Stroke2002，33，4： | 1 |
| 13 | Risk of stroke, transientis chemic attack, and vesselocclusion before end arterectomy inpa- tients with symptomatic severe carotid stenosis 显示文摘 | Blaser T Hofmannk K Buerger T | 2002 | Stroke2002，33，4： | 1 |
| 14 | Use of an open-reading frame-specific Campylobacter jejuni DNA microarray as a new genotyping tool for studying epidemiologically related isolates显示文摘 | Leonard EE 2nd Takata T Blaser MJ | 2003 | J Infect Dis2003，187，4： | 1 |
| 15 | C - H - F C hydrogen bonding in 1,2,3,5 - tetrafluorobenzene and other fluoroaromatic compounds and the crystal structure of alloxan revisited 显示文摘 | Thakur T S Kirchner M T Blaser D | 2010 | CrystEngComm2010，12，： | 1 |
| 16 | Cessation of embolic signals after antithrombotic prevention is related to reduced risk of recurrent arterioembolic transient ischaemic attack and stroke显示文摘 | Blaser T Krueger S | 2002 | J Neurol Neurosurg Psychiatry2002，72，： | 1 |
| 17 | Radiation use effi- ciency in dual winter cereal-forage production systems 显示文摘 | Singer J W Sauer T J Blaser B C | 2007 | Agronomy Journal2007，99，： | 1 |
| 18 | Regulationof tumour necrosis factor signaling: live or let die 显示文摘 | Brenner D Blaser H Mak T W | 2015 | Nature Re- views Immunology2015，15，6： | 1 |
| 19 | STEP ( satellite test of the equivalence principle) 显示文摘 | SUMNER T J ANDERSON J BLASER J P | 2007 | Advances in Space Research2007，，39： | 1 |
| 20 | Use of an openreading frame-specific Campylobacter jejuni DNA microarray as a new genotyping tool for studying epidemiologically related isolates显示文摘 | Leonard EE Takata T Blaser MJ | 2003 | J Infect Dis2003，187，4： | 1 |
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