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| 1 | 猪MyoG基因3′端PCR-SSCP遗传多态性及其遗传效应(英文)显示文摘采用PCR-SSCP方法对长白猪、大白猪、杜洛克猪、山西黑猪和马身猪共636头猪的肌细胞生成素(Myogenin,简称MyoG)基因3′端的遗传多态性进行检测,分析MyoG基因对猪的初生体质量、断奶体质量、6月龄体质量和背膘厚的影响。根据已发表的猪MyoG基因3′端侧翼序列设计3对引物,发现F1/R1引物对扩增的片段有多态性。统计结果发现:长白、大白、杜洛克猪种B基因为优势基因,其基因频率分别为0.8807、0.7256和0.8581;山西黑猪种A基因为优势基因,其基因频率为0.9359;马身猪种只检测到A基因。χ2独立性检验表明,基因型分布在外来猪种(长白猪、大白猪、杜洛克猪)与地方猪种(山西黑猪、马身猪)间存在极显著差异(P<0.01)。固定效应模型分析结果表明,初生体质量基因型间差异显著(P<0.05),而断奶体质量、6月龄体质量和背膘厚基因型间差异不显著(P>0.05)。最小二乘分析结果表明,BB基因型与其它2种基因型比较有较大的初生质量,同AA和AB型比较差异极显著(P<0.01)。因此,推测MyoG基因对个体的初生体质量存在一定的影响,选择带有B等位基因的个体有望提高个体的初生体质量。 | 薛慧良 周忠孝 Bo Well | 2007 | 生态学杂志2007，26，4： | 10 |
| 2 | The Newcastle-Ottawa Scale(NOS) for assessing the quality if nonrandomized studies in meta analyses显示文摘 | Wells GA Shea BO Connell D | 2013 | PLoS Negl Trop Dis2013，7，5： | 1 |
| 3 | Myosin VI is an ac-tin-based motor that moves backwards显示文摘 | Wells AL Lin AW Chen LQ Safer D Cain SM Hasson T Carragher BO Milligan RA Sweeney HL | | 0，，6752： | 1 |
| 4 | PATIENT MONITORING SYSTEM显示文摘PATIENTMONITORINGSYSTEMPATIENTMONITORINGSYSTEMHauGuifen;LiuGuangrong(ChinesePLA.GeneralHospital100853,Beijing,China)SuchasPat... | Yucbeng Zhang Bo Zhang Gengalu Chen et al.(The first Hospital of Harbin Medical University,China)Previously,it was at the secondary acetabulum that the total hip replcement was applied forThe adult’ s CDH as well as pelvis osteotom of the line of grav | 1995 | Chinese Journal of Biomedical Engineering(English Edition)1995，4，4： | 0 |
| 5 | 香秘显示文摘谈到香气可能更多的联想是香水或者精油,但是香气这种无法用眼睛只能用嗅觉感受的气体,随着科学的进步也一步步地被解读。香气到底是由什么物质组成,人又是如何感受香气并识别和解读它,被香气围绕的我们是被幸福包围,还是被危害侵蚀,随着文章的推进让我们一起来揭秘。 | 静波 李红 流芳华 叶欣 Bo Wells Lord Shaw 张雪莲 | 2013 | 人与自然2013，，4： | 0 |
| 6 | Akt isoforms differentially provide for chemoresistance in prostate cancer显示文摘Objective:Early prostate cancer micrometastatic foci undergo a mesenchymal to epithelial reverting transition,not only aiding seeding and colonization,but also rendering the tumor cells generally chemoresistant.We previously found that upregulated E-cadherin in the epithelial micrometastases activated canonical survival pathways,including PI3K-Akt,that protected the tumor cells from death;however,the extent of protection from blocking the pathway in its entirety was modest,because different isoforms may have alternately affected cell functioning.Here,we characterized Akt isoform expressions in primary and metastatic prostate cancers,as well as their individual contributions to chemoresistance.Methods:Akt isoforms and E-cadherin were manipulated with drugs,knocked down,and over expressed.Tumor cell killing was determined in vitro and in vivo.Overall survival was calculated from patient records and specimens.Results:Pan-Akt inhibition sensitized tumor cells to chemotherapy,and specific blockade of Akt1 or/and Akt2 caused cells to be more chemoresponsive.Overexpression of Akt3 induced apoptosis.A low dose of Akt1 or Akt2 inhibitor enabled standard chemotherapies to significantly eradicate metastatic prostate tumors in a mouse model,acting as chemosensitizers.In human specimens,we found Akt1 and Akt2 positively correlated,whereas Akt3 inversely correlated,with the overall survival of prostate cancer patients.Akt1high/Akt2high/Akt3low tumors had the worst outcomes.Conclusions:E-cadherin-induced activation of Akt1/2 isoforms was the essential mechanism of chemoresistance,whereas Akt3 made cells more fragile.These findings emphasized the need to target Akt1/2,rather than pan-Akt,as a rational therapeutic approach. | Bo Ma Hanshuang Shao Xia Jiang Zhou Wang Chuanyue(Cary)Wu Diana Whaley Alan Wells | 2022 | Cancer Biology & Medicine2022，19，5： | 0 |
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