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| 1 | Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes显示文摘Macro and microvascular disease are the main cause of morbi-mortality in type 1 diabetes(T1DM).Although there is a clear association between endothelial dysfunction and atherosclerosis in type 2 diabetes,a cause-effect relationship is less clear in T1 DM.Although endothelial dysfunction(ED) precedes atherosclerosis,it is not clear weather,in recent onset T1 DM,it may progress to clinical macrovascular disease.Moreover,endothelial dysfunction may either be reversed spontaneously or in response to intensive glycemic control,long-term exercise training and use of statins.Acute,long-term and post-prandial hyperglycemia as well as duration of diabetes and microalbuminuria are all conditions associated with ED in T1 DM.The pathogenesis of endothelial dysfunction is closely related to oxidative-stress.NAD(P)H oxidase over activity induces excessive superoxide production inside the mitochondrial oxidative chain of endothelial cells,thus reducing nitric oxide bioavailability and resulting in peroxynitrite formation,a potent oxidant agent.Moreover,oxidative stress also uncouples endothelial nitric oxide synthase,which becomes dysfunctional,inducing formation of superoxide.Other important mechanisms are the activation of both the polyol and protein kinase C pathways as well as the presence of advanced glycation end-products.Future studies are needed to evaluate the potential clinical applicability of endothelial dysfunction as a marker for early vascular complications in T1 DM. | Marcello C Bertoluci Gislaine V Cé Antonio MV da Silva Marco V Wainstein Winston Boff Marcia Punales | 2015 | World Journal of Diabetes2015，6，5： | 5 |
| 2 | Reaching out to the underserved: More than thirty years of outreach job ads 显示文摘 | Boff C Singer C | 2006 | The Journal of Academic Librarianship2006，32，2： | 1 |
| 3 | Reaching Out to the Underserved: More Than Thirty Years of Outreach Job Ads 显示文摘 | Boff C Singer C | 2006 | The Journal of Academic Librarianship2006，，2： | 1 |
| 4 | Nickel complexes based on tridentate pyrazolyl ligands for highly efficient dimerization of ethylene to 1-butene显示文摘 | Ajellal N Kuhn M C A Boff A D G | 2006 | Organometallics2006，25，5： | 1 |
| 5 | Orientation of Heterorhabditis megidis to insect hosts and plant roots in a Y-tube sand olfactometer 显示文摘 | BOFF M I C ZOON F C SMITS P H | 2001 | Entomol Exp Appl2001，98，： | 1 |
| 6 | The indoor air as a potential determinant of the frequency of invasive aspergillosis in the intensive care显示文摘 | BOFF C ZOPPAS BC AQUINO VR | 2013 | Mycoses2013，56，5： | 1 |
| 7 | Plants protect their roots by alerting the enemies of grubs显示文摘 | RobWHM AntonTC Mari1 C Boff | 2001 | Ecology Letters2001，4，4： | 1 |
| 8 | Reaching out to the Underserved: More than Thirty Years of Outreach Job Ads 显示文摘 | Boff C Singer C Steams B | 2006 | Tile Journal of academic librarianship2006，32，2： | 1 |
| 9 | Reaching out to the underserved: More than thirty years of outreach job ads显示文摘 | Boff C Singer C Stearns B | 2006 | The Journal of Academic lAbrarianship2006，32，2： | 1 |
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