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| 1 | Intraductal endoscopic radiofrequency ablation for the treatment of hilar non-resectable malignant bile duct obstruction显示文摘AIM: To evaluate the safety and technical success of endoscopic radiofrequency ablation(RFA) for palliative treatment of malignant hilar bile duct obstruction. METHODS: In this study, a recently CE and FDA-approved endoscopic RFA catheter was first tested in an ex vivo pig liver model to study the effect of electrosurgical variables on the extent of the area of induced necrosis. Subsequently, a retrospective analysis was conducted of all patients treated with endoscopic RFA for malignant biliary obstruction at our center between February 2012 and April 2013. All patients received an additional plastic stent implantation into the biliary tree following RFA. RESULTS: In the pig model, ablation time of 60-90 seconds using the bipolar soft coagulation mode at 8-10 watts with an effect of 8 was found to be the most feasible setting. Twelve patients(5 females, 7 males; mean age, 70 years) underwent 19 endoscopic RFA(range, 1-5) sessions. Deployment of RFA was successful in all patients. Systemic chemotherapy was administered in four patients. We observed biliary bleeding 4-6 wk after the intervention in three cases and two of these patients died: in one patient, spontaneous hemobilia occurred, whereas bleeding started during stent extraction in the other. In the third patient, bleeding was stopped by insertion of a non-covered self-expanding metal stent. Another three patients developed cholangitis during follow-up. Seven patients died during follow-up and median survival was 6.4 mo(95%CI: 0.05-12.7) from the time of the first RFA. CONCLUSION: Endoscopic RFA is an easy to perform and technically highly successful procedure. However, hemobilia possibly associated with RFA occurred in three of our patients. Therefore, larger prospective studies are needed to further evaluate the safety and efficacy of this promising new method. | Andrea Oliver Tal Johannes Vermehren Mireen FriedrichRust Jrg Bojunga Christoph Sarrazin Stefan Zeuzem Jrg Trojan Jrg Gerhard Albert | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，1： | 18 |
| 2 | Real-time elastography for the differen- tiation of benign and malignant thyroid nodule 显示文摘 | Bojunga J Herrmann E | 2010 | Thyroid2010，20，： | 1 |
| 3 | Real-time elastography for the differentiation of benign and malignant thyroid nodules: a meta-analysis 显示文摘 | Bojunga J Herrmann E Meyer G | 2010 | Thyroid2010，20，10： | 1 |
| 4 | Severe lactic acidosis during treatment of chronic hepatitis B with entecavir in patients with impaired liver function 显示文摘 | Lange CM Bojunga J Hofmann WP | 2009 | Hepatology2009，50，6： | 1 |
| 5 | Detection of thyroid peroxidase mRNA in peripheral blood of patients with malignant and benign thyroid diseases显示文摘 | Roddiger S J Bojunga J Klee V | 2002 | Mol Endocrinol2002，29，3： | 1 |
| 6 | Urapidil in the preoperative treat-ment of pheochromocytomas: a safe and cost - effective method 显示文摘 | Habbe N Ruger F Bojunga J | 2013 | World J Surg2013，37，5： | 1 |
| 7 | Acoustic radiation forceimpulse imaging for differentiation of thyroid nodules显示文摘 | Bojunga J Dauth N Berner C | 2012 | PLoS One2012，7，42： | 1 |
| 8 | Realtime elastogra phy for the differentiation of benign and malignant thyroid nodules: ameta-analysis 显示文摘 | Bojunga J HerrmannE Meyer G | 2010 | Thyroid2010，20，10： | 1 |
| 9 | Detection of thyroid peroxidase mRNA in peripheral blood of patients with malignant and benign thyroid diseases 显示文摘 | Bojunga J Klee V | 2002 | Mol Endocrinol2002，29，3： | 1 |
| 10 | Antioxidative treatment prevents activation of death-receptor-and mitochondrion-dependent apoptosis in the hearts of diabetic rats显示文摘 | Bojunga J Nowak D Mitrou PS | 2004 | Diabetologia2004，47，12： | 1 |
| 11 | Real-time elastography for the differentiation of benign and malignant thyroid nodules : a meta-analysis显示文摘 | BOJUNGA J HERRMANN E MEYER G | 2010 | Thyroid2010，20，10： | 1 |
| 12 | Real-time elastography for the differentiation of benign and malignant thyroid nodules:ameta-analysis显示文摘 | Bojunga J Herrmann E Meyer G | 2010 | Thyroid2010，20，10： | 1 |
| 13 | Antioxidative treat- ment prevents activation of death-receptor- and mitoehondrion- dependent apoptosis in the hearts of diabetic rats 显示文摘 | Bojunga J Nowak D Mitrou P S | 2004 | Dia-betologia2004，47，12： | 1 |
| 14 | Se- vere lactic acidosis during treatment of chronic hepatitis B with enteeavir in patients with impaired liver function 显示文摘 | LANGE C M BOJUNGA J HOFMANN W P | 2009 | Hepatology2009，50，6： | 1 |
| 15 | Severe lactic acidosisduring treatment of chronic hepatitis B with ente-cavir in patientswith impaired liver显示文摘 | Lange CM Bojunga J Hofmann WP | | 0，，06： | 1 |
| 16 | Acoustic radiation force impulse imaging for differentiation of thyroid nodules显示文摘 | Bojunga J Danth N Bemer C | 2012 | PLoS One2012，7，42： | 1 |
| 17 | Acoustic radiation forceimpulse imaging for differentiation of thyroid nodules显示文摘 | Bojunga J Dauth N Berner C | 2012 | PLoSONE2012，7，42： | 1 |
| 18 | Antioxidative treatment reverses imbalances of nitric oxide synthase isoform expression and attenuates tissue-cGMP activation in diabetic rats 显示文摘 | Bojunga J Dresar-Mayert B Usadel KH | 2004 | Biochem Biophys Res Commun2004，9316，3： | 1 |
| 19 | Antioxidative treatment prevents activation of death-receptor-and mitochondrion-dependent apoptosis in the hearts of diabetic rats显示文摘 | Bojunga J Nowak D Mitrou PS | 2004 | Diabetologia2004，47，12： | 1 |
| 20 | Real - time elastography for the differentiation of benign and malignant thyroid nodules, A meta - analysis显示文摘 | Bojunga J Herrmann E Meyer G | 2010 | Thyroid2010，，10： | 1 |
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