|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Optimal Predictive Control for Path Following of a Full Drive-by-Wire Vehicle at Varying Speeds显示文摘The current research of the global chassis control problem for the full drive-by-wire vehicle focuses on the control allocation(CA) of the four-wheel-distributed traction/braking/steering systems. However, the path following performance and the handling stability of the vehicle can be enhanced a step further by automatically adjusting the vehicle speed to the optimal value. The optimal solution for the combined longitudinal and lateral motion control(MC)problem is given. First, a new variable step-size spatial transformation method is proposed and utilized in the prediction model to derive the dynamics of the vehicle with respect to the road, such that the tracking errors can be explicitly obtained over the prediction horizon at varying speeds. Second, a nonlinear model predictive control(NMPC) algorithm is introduced to handle the nonlinear coupling between any two directions of the vehicular planar motion and computes the sequence of the optimal motion states for following the desired path. Third, a hierarchical control structure is proposed to separate the motion controller into a NMPC based path planner and a terminal sliding mode control(TSMC) based path follower. As revealed through off-line simulations, the hierarchical methodology brings nearly 1700% improvement in computational efficiency without loss of control performance. Finally, the control algorithm is verified through a hardware in-the-loop simulation system. Double-lanechange(DLC) test results show that by using the optimal predictive controller, the root-mean-square(RMS) values of the lateral deviations and the orientation errors can be reduced by 41% and 30%, respectively, comparing to those by the optimal preview acceleration(OPA) driver model with the non-preview speed-tracking method. Additionally,the average vehicle speed is increased by 0.26 km/h with the peak sideslip angle suppressed to 1.9°. This research proposes a novel motion controller, which provides the full drive-by-wire vehicle with better lane-keeping and collision-avoidance capabilities during autonomous driving. | Pan SONG Bolin GAO Shugang XIE Rui FANG | 2017 | Chinese Journal of Mechanical Engineering2017，30，3： | 4 |
| 2 | SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron strain(as Rnown as B.1.1.529)was identified in Botswana and South Africa in early November 2021 and was later defined as a new variant of concern(VOC)by the World Health Organization on November 26,2021.1,2 To date,the con firmed cases of Omicro n have been reported in more than 38 countries,and the number of cases appears to be rapidly in creasing.SARS-CoV-2 Omicron could give rise to the fourth wave of the COVID-19 epidemic spreading around the world,following the D614G,Beta/Gamma,and Delta VOCs. | Xiantao Zhang Shijian Wu Bolin Wu Qirui Yang Achun Chen Yuzhuang Li Yiwen Zhang Ting Pan Hui Zhang Xin He | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 1 |
| 3 | Cationic and Anionic Antimicrobial Agents Co‑Templated Mesostructured Silica Nanocomposites with a Spiky Nanotopology and Enhanced Biofilm Inhibition Performance显示文摘Silica-based materials are usually used as delivery systems for antibacterial applications.In rare cases,bactericidal cationic surfactant templated silica composites have been reported as antimicrobial agents.However,their antibacterial efficacy is limited due to limited control in content and structure.Herein,we report a“dual active templating”strategy in the design of nanostructured silica composites with intrinsic antibacterial performance.This strategy uses cationic and anionic structural directing agents as dual templates,both with active antibacterial property.The cationic-anionic dual active templating strategy further contributes to antibacterial nanocomposites with a spiky surface.With controllable release of dual active antibacterial agents,the spiky nanocomposite displays enhanced anti-microbial and anti-biofilm properties toward Staphylococcus epidermidis.These findings pave a new avenue toward the designed synthesis of novel antibacterial nanocomposites with improved performance for diverse antibacterial applications. | Yaping Song Qiang Sun Jiangqi Luo Yueqi Kong Bolin Pan Jing Zhao Yue Wang Chengzhong Yu | 2022 | Nano-Micro Letters2022，14，5： | 0 |
| 4 | PanGu Drug Model: learn a molecule like a human显示文摘Dear Editor,Recent achievements in large-scale pre-trained models like GPT-3 and PanGu-α have demonstrated astounding performances in many downstream tasks of natural language processing (NLP),confirming AI to be user-oriented for even industrial applications.Deep learning has been recognized as the most promising technology for pharmaceuticals,a powerful molecule pre-trained model that could economize researchers’tons of time.For the strategic application of AI capabilities to the drug discovery field,we pre-trained a model called PanGu Drug Model with 1.7 billion small molecules from ZINC20 (Irwin et al.,2020),DrugSpaceX(Yang et al.,2021),and UniChem (Chambers et al.,2013). | Xinyuan Lin Chi Xu Zhaoping Xiong Xinfeng Zhang Ningxi Ni Bolin Ni Jianlong Chang Ruiqing Pan Zidong Wang Fan Yu Qi Tian Hualiang Jiang Mingyue Zheng Nan Qiao | 2023 | Science China(Life Sciences)2023，66，4： | 0 |
| 5 | The Streptococcus agalactiae Ribose Binding Protein B (RbsB) Mediates Quorum Sensing Signal Uptake via Interaction with Autoinducer-2 Signals显示文摘Understanding aquatic pathogen in sediments or aquacultural water is crucial to protect public health from soilborne and waterborne diseases.Quorum sensing(QS)was increasingly reported in biological wastewater treatment processes because of their inherent roles in biofilm development,bacterial aggregation and so on.The widely QS signals was Antoinducer-2(AI-2),primarily involved to allow the possibility of interspecies communication.However,the cellular components that mediate the response of Streptococcus agalactiae to AI-2 have not been fully characterized.Analysis of the complete genome sequence of S.agalactiae indi-cated that its RbsB protein has similarity to Escherichia coli LsrB and Aggregatibacter actinomycetemcomitans RbsB proteins that bind AI-2.We hypothesized that RbsB protein mediates quorum sensing signal uptake via interaction with AI-2.To evaluate the regulatory effect of RbsB on QS system,the recombinant plasmid pGEX-6p-1-RbsB was constructed and RbsB protein was purified with GST-tag.To further elucidate the role of RbsB protein binding to DPD(AI-2 precursor dihydroxypentanedione),the systemati-cally throughput circular dichroism(CD)spectroscopy,isothermal titration calorimetry200(ITC200)and molecular docking methods were employed.The high expression of soluble RbsB protein with molecular weight of 33 kDa was obtained.The thermodynamics results(ΔH<0,ΔS<0,ΔG<0)with ITC determination indicated that the binding process between DPD and RbsB was exothermic and spontaneous,with hydrogen bonds and van der Waals forces as the main binding forces.Obviously,DPD can be more easily combined with RbsB in a dose-dependent manner,suggesting that RbsB was changed in the microenvironment of DPD when the DPD concentration was between 0.8-1.0mmolL−1 and reaching the maximum binding amount.According to molecular docking,3 hydrophobic residues involved in DPD and RbsB protein stable binding were be found,and also hydrogen bonding plays a key role in the formation of the new complex.RbsB efficiently inhibited V.harveyi bioluminescence induced by both S.agalactiae AI-2 and V.harveyi AI-2 in a dose-dependent manner.However,our results suggest that RbsB may play a role in the response of S.agalactiace to AI-2. | FAN Bolin PAN Lixia WANG Zhongliang WANGKAHART Eakapol HUANG Yuchong YANG Dengfeng JIAN Jichang HUANG Yu WANG Bei | 2021 | Journal of Ocean University of China2021，20，5： | 0 |
| 6 | USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID显示文摘Activation-induced cytidine deaminase(AID)initiates class-switch recombination and somatic hypermutation(SHM)in antibody genes.Protein expression and activity are tightly controlled by various mechanisms.However,it remains unknown whether a signal from the extracellular environment directly affects the AID activity in the nucleus where it works.Here,we demonstrated that a deubiquitinase USP10,which specifically stabilizes nuclear AID protein,can translocate into the nucleus after AKT-mediated phosphorylation at its T674 within the NLS domain.Interestingly,the signals from BCR and TLR1/2 synergistically promoted this phosphorylation.The deficiency of USP10 in B cells significantly decreased AID protein levels,subsequently reducing neutralizing antibody production after immunization with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)or human immunodeficiency virus type 1(HIV-1)nanoparticle vaccines.Collectively,we demonstrated that USP10 functions as an integrator for both BCR and TLR signals and directly regulates nuclear AID activity.Its manipulation could be used for the development of vaccines and adjuvants. | Yuewen Luo Xiantao Zhang Ran Chen Rong Li Yang Liu Junsong Zhang Qin liu Meijun Si Jun Liu Bolin Wu Xuemei Wang Shijian Wu Yiwen Zhang Xu Zhang Deyin Guo Xin He Ting Pan Hui Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 0 |
| 7 | Stabilizing supported gold catalysts in acetylene hydrochlorination by constructing an acetylene–deficient reaction phase显示文摘In the process of acetylene hydrochlorination,the rapid deactivation of supported gold(Au)catalysts by acetylene is still a huge challenge.Here,we provide an innovative strategy for constructing an acetylene–deficient reaction phase on the active site by coating an ionic liquid film on the Au(H2O)/C surface.The reactant ratio of C2H2 to HCl in this acetylene–deficient reaction phase is 1:132,in contrast to the 1:1 M ratio in the gas phase,thus boosting the catalytic stability of Au(H2O)/C catalysts.The kinetic and theoretical analysis showed that the reduction of cationic gold by C2H2 and the generation of carbon deposition can be inhibited in this constructed reaction phase during reaction.The current work not only broadens the scope of supported Au catalysts in acetylene hydrochlorination,but also verifies the perspective of the tunability of stoichiometric balance,which can be used in other catalytic applications. | Bolin Wang Yuxue Yue Saisai Wang Shujuan Shao Zhi Chen Xianhua Fang Xiangxue Pang Zhiyan Pan Jia Zhao Xiaonian Li | 2021 | Green Energy & Environment2021，6，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员