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43篇 您的检索式:作者名="Bongaarts"
    题名 作者 年代 出处 被引量
1miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 2018神经损伤与功能重建2018,13,12:3
2A model of the spread of HIV infection and the demo- graphic impact of AIDS 显示文摘Bongaarts J 1989Statistics in Medicine1989,8,1:1
3Hyperkeratosis lenticularis perstans (Flegel) 显示文摘van de Staak W J Bergers AM Bongaarts P 1980Dermatol1980,161,:1
4The End of the Fertility Transition in the Developing World 显示文摘Bongaarts J 2002Population Bulletin of the United Nations2002,48,:1
5A framework for analyzing the proximate determinants of fertility 显示文摘BONGAARTS J 1978Population and Development Review1978,4,1:1
6Human population growth and the demographic transition显示文摘Bongaarts J 2009Philos Trans R Soc Lond B Biol Sci2009,364,25:1
7The fertility impact of changes in the timing of childbearing in the developing world 显示文摘Bongaarts J 1999Population Studies1999,54,3:1
8An Alternative to the One Child Policy in China显示文摘BONGAARTS J GREENHALGH S 1985Population and Development Review1985,11,4:1
9Can family planning programs reduce high desired family size in sub-Saharan Africa显示文摘Bongaarts J 0,,04:1
10Fertility Policy in China:Future Options显示文摘GREENHALGH S BONGAARTS J 1987Science1987,235,4793:1
11Population growth and global warming 显示文摘Bongaarts J 1992Population and Development Review1992,18,2:1
12A Demographic Explanation for the Recent Rise in European Fertility 显示文摘Bongaarts J and Tom6 Sobotka 2012Population and Development Review2012,1,:1
13Fertility and Reproductive Preferences in Post-transitional Societies 显示文摘Bongaarts J 2001Population and Development Review2001,28,:1
14Fertility and Reproductive Preferences in Post-transitional Societies 显示文摘Bongaarts J 2001Population and Development Review2001,,27:1
15On the Quantum and Tempo of Fertility 显示文摘Bongaarts J and Griffith Feeney 1988Population and Development Review1988,2,:1
16Infant orthopedics has no effect on maxillary arch dimensions in the deciduous dentition of children with complete unilateral cleft lip and palate (Dutchcleft)显示文摘Bongaarts CA van't Hof MA Prahl-Andersen B 0,,06:1
17Population Aging and the Rising Cost of Public Pensions显示文摘Bongaarts J 2004Population and Development Review2004,,30:1
18The End of the Fertility Transition in the Developed World 显示文摘Bongaarts J 2002Population and Development Review2002,28,3:1
19How long will we live?显示文摘Bongaarts J 2006Population and De-velopment Review2006,,4:1
20Fertility and Reproductive Preferences in Post - transitional Societies 显示文摘John Bongaarts 2001Population and Development Review2001,,27:1
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