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10篇 您的检索式：作者名="Boon AI"

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		题名	作者	年代	出处	被引量
	1	Dutch normalpressure hydrocephalus study, prediction of outcome after shunting by resistance to outflow of cerebrospinal fluid显示文摘	Boon AI Tans JT Delwel EJ	1997	J Neurosurg1997，87，：	1
	2	Clinical and genetic heterogeneity in multifocal vitelliform dystrophy显示文摘	Boon CJ Klevering BJ den Hollander AI	2007	Arch Ophthalmo12007，125，：	1
	3	Dose Planning Study of Target Volume Coverage with Intensity - Modulated Radio- therapy for Nasopharyngeal Carcinoma: Penang General Hospital Ex- perience显示文摘	Vincent P C E Boon Seang T Ai Lian T	2013	Asian Pacific Journal of Cancer Prevention Apjcp2013，14，4：	1
	4	Impact and ma- nagement of skin toxicity associated with anti-epidermal growth factor receptor therapy: survey results显示文摘	Boone S L Rademaker A Liu D et ai	2007	On- cology2007，72，3：	1
	5	Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts显示文摘Cytochrome P4502J2(CYP2J2)metabolizes arachidonic acid(AA)to cardioprotective epoxyeicosatrienoic acids(EETs).Dronedarone,an antiarrhythmic drug prescribed for treatment of atrial fibrillation(AF)induces cardiac adverse effects(AEs)with poorly understood mechanisms.We previously demonstrated that dronedarone inactivates CYP2J2 potently and irreversibly,disrupts AA-EET pathway leading to cardiac mitochondrial toxicity rescuable via EET enrichment.In this study,we investigated if mitigation of CYP2J2 inhibition prevents dronedarone-induced cardiac AEs.We first synthesized a deuterated analogue of dronedarone(termed poyendarone)and demonstrated that it neither inactivates CYP2J2,disrupts AA-EETs metabolism nor causes cardiac mitochondrial toxicity in vitro.Our patch-clamp experiments demonstrated that pharmacoelectrophysiology of dronedarone is unaffected by deuteration.Next,we show that dronedarone treatment or CYP2J2 knockdown in spontaneously beating cardiomyocytes indicative of depleted CYP2J2 activity exacerbates beat-to-beat(BTB)variability reflective of proarrhythmic phenotype.In contrast,poyendarone treatment yields significantly lower BTB variability compared to dronedarone in cardiomyocytes indicative of preserved CYP2J2 activity.Importantly,poyendarone and dronedarone display similar antiarrhythmic properties in the canine model of persistent AF,while poyendarone substantially reduces beat-to-beat variability of repolarization duration suggestive of diminished proarrhythmic risk.Our findings prove that deuteration of dronedarone prevents CYP2J2 inactivation and mitigates dronedarone-induced cardiac AEs.	Aneesh V.Karkhanis Gopalakrishnan Venkatesan Ryuichi Kambayashi Jacqueline Wen Hui Leow Marcus Qingrui Han Hiroko Izumi-Nakaseko Ai Goto Jeremy Kah Sheng Pang Boon Seng Soh Pipin Kojodjojo Atsushi Sugiyama Eric Chun Yong Chan	2022	Acta Pharmaceutica Sinica B2022，12，10：	1
	6	Reduced mlcroRNA-150 is assoeialed with poor survival in puhunnarv arterial hypertension显示文摘	Rhodes CJ Wharton J Boon RA et ai	2013	Am J Respir Crit Care Med2013，187，3：	1
	7	Application of the- TEX86 temperature proxy in the southern North Sea显示文摘	Herfort L Schouten S Boon J P et ai	2006	Or- ganic Geochemistry2006，37，：	1
	8	Diagnostic value of routine aqueous contrast swallow examination after oesophagectomy for detecting leakage ot' the cervical oesophagogastric anastomosis 显示文摘	Boone J Rinkes IB van Leeuwen M et aI	2005	Eur SurgRes2005，37，2：	1
	9	Comparative cost-effectiveness of 11 oral antipsychotics for relapse prevention in schizophrenia within Singapore using effectiveness estimates from a network meta-analysis显示文摘	Liang Lin Ying J. Zhao Hui J. Zhou Ai L. Khoo Monica Teng Lay B. Soh Boon P. Lim Kang Sim	2016	International Clinical Psychopharmacology2016，，2：	1
	10	The spectrum of retinal dystrophies caused by mutations in the peripherin/RDS gene显示文摘	Boon CJ den Hollander AI Hoyng CB	2008	Prog Retin Eye Res2008，27，2：	1

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