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| 1 | Are faecal markers good indicators of mucosal healing in inflammatory bowel disease?显示文摘AIM: To review the published literature concerning the accuracy of faecal inflammatory markers for identifying mucosal healing. METHODS: Bibliographical searches were performed in MEDLINE electronic database up to February 2015,using the following terms: 'inflammatory bowel disease','Crohn′s disease','ulcerative colitis','faecal markers','calprotectin','lactoferrin','S100A12','endoscop*','mucosal healing','remission'. In addition,relevant references from these studies were also included. Data were extracted from the published papers including odds ratios with 95%CI,P values and correlation coefficients. Data were grouped together according to each faecal marker,Crohn's disease or ulcerative colitis,and paediatric compared with adult study populations. Studies included in this review assessed mucosal inflammation by endoscopic and/or histological means and compared these findings to faecal marker concentrations in inflammatory bowel diseases(IBD) patient cohorts. Articles had to be published between 1990 and February 2015 and written in English. Papers excluded from the review were those where the faecal biomarker concentration was compared between patients with IBD and controls or other disease groups,those where serum biomarkers were used,those with a heterogeneous study population and those only assessing post-operative disease. RESULTS: The available studies show that faecal markers,such as calprotectin and lactoferrin,are promising non-invasive indicators of mucosal healing. However,due to wide variability in study design,especially with regard to the definition of mucosal healing and evaluation of marker cut offs,the available data do not yet indicate the optimal roles of these markers. Thirty-six studies published between 1990 and 2014 were included. Studies comprised variable numbers of study participants,considered CD(15-164 participants) or UC(12-152 participants) separately or as a combined group(11-252 participants). Eight reports included paediatric patients. Several indices were used to document mucosal inflammation,encompassing elevenendoscopic and eight histologic grading systems. The majority of the available reports focused on faecal calprotectin(33 studies),whilst others assessed faecal lactoferrin(13 studies) and one study assessed S100A12. Across all of the biomarkers,there is a wide range of correlation describing the association between faecal markers and endoscopic disease activity(r values ranging from 0.32 to 0.87,P values ranging from < 0.0001 to 0.7815). Correlation coefficients are described in almost all studies and are used more commonly than outcome measures such as sensitivity,specificity,PPV and/or NPV. Overall,the studies that have evaluated faecal calprotectin and/or faecal lactoferrin and their relationship with endoscopic disease activity show inconsistent results. CONCLUSION: Future studies should report the results of faecal inflammatory markers in the context of mucosal healing with clear validated cut offs. | Gudula JAM Boon Andrew S Day Chris J Mulder Richard B Gearry | 2015 | World Journal of Gastroenterology2015，21，40： | 4 |
| 2 | EFNS guideline on the management of status epileptieus in adults显示文摘 | Meierkord H Boon P Engelsen B | 2010 | Eur J Neurol2010，17，3： | 1 |
| 3 | Comparison of predicted and measured air flow patterns in a mechanically ventilated livestock building without animals 显示文摘 | Harral B B Boon C R | 1997 | Journal of Agricultural Engineering Research1997，66，： | 1 |
| 4 | Variations of the position of the colon as applied to percutaneous nephrostomy显示文摘 | Boon JM Shinners B Meiring JH | 2001 | Surg Radiol Anat2001，23，3： | 1 |
| 5 | EFNS guideline on the management of status epilepticus in adults 显示文摘 | Meierkord H Boon P Engelsen B | 2010 | Eur J Neurol2010，17，3： | 1 |
| 6 | Stereospecific effect of hexachlorocyclohexane on activity and structure of soil methanotrophic communities显示文摘 | Mertens B Boon N Verstraete W | 2005 | Environmental Microbiology2005，7，5： | 1 |
| 7 | A phenomenographic study of English faculty' s behavior conceptions of information literacy 显示文摘 | BOON S JOHNSTON B WEBBER S | 2007 | Journal of documentation2007，63，2： | 1 |
| 8 | Grazing systems are a result of equilibrium and non-equilibrium dynamics显示文摘 | DERRY J F BOONE R B | 2010 | Journal of Arid Environments Elsevier Ltd2010，74，2： | 1 |
| 9 | Old drugs,new tricks:using genetically sensitized yease to reveal drug targets显示文摘 | Hughes T Andrews B Boone C | 2004 | Cell2004，116，： | 1 |
| 10 | Congenital hemangioma:evidence of accelerated involution显示文摘 | BOON L M ENJOLRAS O MULLIKEN J B | 1996 | J Pediatr1996，128，3： | 1 |
| 11 | Variations of the position of the colon as applied to percutaneous nephrostomy显示文摘 | BOON J M SHINNERS B MEIRING J H | 2001 | Surg Radiol Anat2001，25，6： | 1 |
| 12 | Tumor antigens recognized by T lymphocytes显示文摘 | Boon T Cerottini JC Van den Eynde B | | Annu Rev Immunol0，1994，12： | 1 |
| 13 | City structure, obesity, and environmental justice: An integrated analysis of physical and social barriers to walkable streets and park access 显示文摘 | CuRs B B Darby K J Boone C G Brewis A | 2009 | Social Science & Medicine2009，69，9： | 1 |
| 14 | Levels of some polybrominated dipheny! ether (PBDE) flame retardants along the Dutch coast as derived from their accumulation in SPMDs and blue mussels (Mytilus edulis) 显示文摘 | Booij K Zegers B N Boon J P | 2002 | Chemosphere2002，46，5： | 1 |
| 15 | R&D on lithium batteries in the USA; high-energy electrode materials显示文摘 | WILLIAM H S | 1999 | Power Sources1999，8182，： | 1 |
| 16 | Developing a sustainable process to provide quality control materials for genetic testing显示文摘 | Chen B O?Connell CD Boone DJ | 2005 | Genet Med2005，7，8： | 1 |
| 17 | Opinion of Belgian neurologists on antiepileptic drugs: Belgian Study on Epilepsy Treatment (BESET) 显示文摘 | Legros B Boon P Dejonghe P | 2007 | Acta Neurol Scand2007，115，2： | 1 |
| 18 | A Polling Model with Multiple Priority Levels 显示文摘 | BOON M A A ADAN I J B F BOXMA 0 J | 2010 | Performance Evaluation2010，67，1： | 1 |
| 19 | Internal Hernias after Laparoscopic Roux-en-Y Gastric Bypass: Incidence, Treatment and Prevention显示文摘 | Kelvin D Higa MD FACS Tienchin Ho MD Keith B Boone MD FACS | 2003 | Obesity Surgery2003，，3： | 1 |
| 20 | Neuropsychological correlates of white matter lesions in healthy elderly subjects显示文摘 | Boone K Miller B Lesser I | 1992 | Arch Neurol1992，49，： | 1 |
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