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| 1 | Fecal lactoferrin accurately reflects mucosal inflammation in inflammatory bowel disease显示文摘BACKGROUND Studies have demonstrated a potential role for fecal biomarkers such as fecal calprotectin(FC)and fecal lactoferrin(FL)in monitoring inflammatory bowel diseases(IBD)-Crohn's disease(CD)and ulcerative colitis(UC).However,their correlation to endoscopic scores,disease severity and affected intestinal surface has not been extensively investigated.AIM To correlate FL,and for comparison white blood cell(WBC)and C-reactive protein(CRP),with endoscopic scores,disease extent and location in CD and UC.METHODS Retrospective analysis in 188 patients who had FL,CRP and WBC determined within 30 d of endoscopy.Disease location,disease extent(number of intestinal segments involved),disease severity(determined by endoscopic scores),timing of FL testing in relation to colonoscopy,as well as the use of effective fast acting medications(steroids and biologics)between colonoscopy and FL measurement,were recorded.RESULTS In 131 CD and 57 UC patients,both CRP and FL-but not WBC-distinguished disease severity(inactive,mild,moderate,severe).In patients receiving fastacting(steroids or biologics)treatment in between FL and colonoscopy,FL showed a higher correlation to endoscopic scores when tested before vs after the procedure(r=0.596,P<0.001,vs r=0.285,P=0.15 for the Simple Endoscopic Score for CD;and r=0.402,P=0.01 vs r=0.054 P=0.84 for Disease Activity Index).Finally,FL was significantly correlated with the diseased mucosal surface(colon-ileocolon>small bowel)and the number of inflamed colon segments.CONCLUSION FL and CRP separated disease severity categories with FL showing lower discriminating P-values.FL showed a close correlation with the involved mucosal surface and with disease extent and was more closely correlated to endoscopy when determined before the procedure–this indicating that inflammatory activity changes associated with therapy might be rapidly reflected by FL levels.FL can accurately and timely characterize intestinal inflammation in IBD. | Marrieth G Rubio Kofi Amo-Mensah James M Gray Vu Q Nguyen Sam Nakat Douglas Grider Kim Love James H Boone Dario Sorrentino | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，5： | 4 |
| 2 | EFNS guideline on the management of status epileptieus in adults显示文摘 | Meierkord H Boon P Engelsen B | 2010 | Eur J Neurol2010，17，3： | 1 |
| 3 | Comparing Acquisitions and Divestitures 显示文摘 | Boone A L Mulherin H | 2000 | Journal of Corporate Finance2000，6，2： | 1 |
| 4 | Plant and soil responses to three years of chronic nitrogen additions at the Harvardforest, Massachusetts显示文摘 | Aber J D Mcdowell W H Boone R | 1993 | Ecological Applications1993，3，1： | 1 |
| 5 | Repair of ruptured tendinous chords in the newborn with flail tricuspid valve and functional pulmonary atresia 显示文摘 | BOON R HRUDA J SCHOOF P H | 2007 | Int J Cardiol2007，116，3： | 1 |
| 6 | EFNS guideline on the management of status epilepticus in adults 显示文摘 | Meierkord H Boon P Engelsen B | 2010 | Eur J Neurol2010，17，3： | 1 |
| 7 | De-mand articulation in emerging technologies: intermediary user organisations as co-producers? 显示文摘 | BOON W P C MOORS E H M KUHLMANN S | 2010 | Research Policy2010，40，2： | 1 |
| 8 | Bronfenbrenner's Bioeeological Theory for Modelling Community Resilience to Natural Disasters显示文摘 | BOON H J COTrRELL A KING D | 2012 | Natural Hazards2012，60，2： | 1 |
| 9 | Comparing acquisitions and divestitures 显示文摘 | MULHERIN J H BOONE A L | 2000 | Journal of Corporate Finance2000，6，2： | 1 |
| 10 | Variations of the position of the colon as applied to percutaneous nephrostomy显示文摘 | BOON J M SHINNERS B MEIRING J H | 2001 | Surg Radiol Anat2001，25，6： | 1 |
| 11 | Microwave stabilization versus chemical fixation:A morphometric study in glycolmethacrylate - and paraffin-embedded tissue显示文摘 | Van de Kant H J De Booij D G Boon M E | 1990 | Histochem J1990，22，67： | 1 |
| 12 | Impacts of wind power minute-to-minute variations on power system operation显示文摘 | BANAKAR H LUO Changling BOON T O | 2008 | Power Systems2008，23，1： | 1 |
| 13 | R&D on lithium batteries in the USA; high-energy electrode materials显示文摘 | WILLIAM H S | 1999 | Power Sources1999，8182，： | 1 |
| 14 | Ganome-wide expression profiling reveals EBV-associated inhibition of MHC class I expression in nasopharyngeal carcinoma显示文摘 | SENGUPTA S DEN BOON J A CHEN I H | 2006 | Cancer Res2006，66，16： | 1 |
| 15 | Oxide adhesion and growth characteristics on platinum-modified aluminide coatings显示文摘 | Farrell M S Boone D H | 1987 | Surface and Coatings Technology1987，32，14： | 1 |
| 16 | Removal of dyes and industrial dye waste bymagnesium chloride显示文摘 | Boon H T | 2000 | Water Research2000，34，2： | 1 |
| 17 | Flue gas compounds and microalgae: (Bio-) chemical interactions leading to biotechnological opportunities 显示文摘 | VAN DEN HENDE S VERVAEREN H BOON N | 2012 | Biotechnology Advances2012，30，6： | 1 |
| 18 | Microbial fuel cells operating on mixed fatty acids 显示文摘 | Freguia S Teh E H Boon N | 2010 | Bioresource Technology2010，101，4： | 1 |
| 19 | Probiotics in aquaculture of Chinacurrent state,problems and prospect显示文摘 | Qi Z Zhang X H Boon N | 2009 | Aquaculture2009，290，1： | 1 |
| 20 | Comparing Acquisitions and Divestitures显示文摘 | MULHERIN J H BOONE A L | 2000 | Journal of Corporate Finance2000，6，2： | 1 |
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