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| 1 | Treatment strategies using adefovir dipivoxil for individuals with lamivudine-resistant chronic hepatitis B显示文摘AIM:To investigate retrospectively the long-term efficacy of various treatment strategies using adefovir dipivoxil(adefovir) in patients with lamivudine-resistant chronic hepatitis B.METHODS:We included 154 consecutive patients in two treatment groups:the 'add-on' group(n = 79),in which adefovir was added to ongoing lamivudine treatment due to lamivudine resistance,and the 'switch/combination' group(n = 75),in which lamivudine was first switched to adefovir and then re-added later as needed.The 'switch/combination' group was then divided into two subgroups depending on whether participants followed(group A,n = 30) or violated(group B,n = 45) a proposed treatment strategy that determined whether to add lamivudine based on the serum hepatitis B virus(HBV) DNA levels(< 60 IU/mL or not) after 6 mo of treatment(roadmap concept).RESULTS:The cumulative probability of virologic response(HBV DNA < 60 IU/mL) was higher in group A than in the 'add-on' group and in group B(P < 0.001).In contrast,the cumulative probability of virologic breakthrough was lower in the 'add-on' group than in group B(P = 0.002).Furthermore,the risk of virologic breakthrough in the multivariate analysis was significantly lower in the 'add-on' group than in group A(hazard ratio = 0.096;95%CI,0.015-0.629;P = 0.015).CONCLUSION:The selective combination of adefovir with lamivudine based upon early treatment responses increased the odds of virologic breakthrough relative to the use of uniform combination therapy from the beginning of treatment. | Tae Jung Yun Jin Yong Jung Chang Ha Kim Soon Ho Um Hyonggin An Yeon Seok Seo Jin Dong Kim Hyung Joon Yim Bora Keum Yong Sik Kim Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu | 2012 | World Journal of Gastroenterology2012，18，47： | 19 |
| 2 | Computed tomography findings for predicting severe acute hepatitis with prolonged cholestasis显示文摘AIM: To evaluate the significance of computed tomography (CT) findings in relation to liver chemistry and the clinical course of acute hepatitis. METHODS: Four hundred and twelve patients with acute hepatitis who underwent enhanced CT scanning were enrolled retrospectively. Imaging findings were analyzed for the following variables: gallbladder wall thickness (GWT), arterial heterogeneity, periportal tracking, number and maximum size of lymph nodes, presence of ascites, and size of spleen. The serum levels of alanine aminotransferase, alkaline phosphatase, bilirubin, albumin, and prothrombin time were measured on the day of admission and CT scan, and laboratory data were evaluated every 2-4 d for all subjects during hospitalization. RESULTS: The mean age of patients was 34.4 years, and the most common cause of hepatitis was hepatitis A virus (77.4%). The mean GWT was 5.2 mm. The number of patients who had findings of arterial heterogeneity, periportal tracking, lymph node enlargement > 7 mm, and ascites was 294 (80.1%), 348 (84.7%), 346 (84.5%), and 56 (13.6%), respectively. On multivariate logistic regression, male gender [odds ratio (OR) = 2.569, 95%CI: 1.477-4.469, P = 0.001], toxic hepatitis (OR = 3.531, 95%CI: 1.444-8.635, P = 0.006), level of albumin (OR = 2.154, 95%CI: 1.279-3.629, P = 0.004), and GWT (OR = 1.061, 95%CI: 1.015-1.110, P = 0.009) were independent predictive factors for severe hepatitis. The level of bilirubin (OR = 1.628, 95%CI: 1.331-1.991, P < 0.001) and GWT (OR = 1.172, 95%CI: 1.024-1.342,P = 0.021) were independent factors for prolonged cholestasis in multivariate analysis. CONCLUSION: In patients with acute hepatitis, GWT on CT scan was an independent predictor of severe hepatitis and prolonged cholestasis. | Sang Jung Park Jin Dong Kim Yeon Seok Seo Beom Jin Park Min Ju Kim Soon Ho Um Chang Ha Kim Hyung Joon Yim Soon Koo Baik Jin Yong Jung Bora Keum Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu | 2013 | World Journal of Gastroenterology2013，19，16： | 4 |
| 3 | Psychometric Hepatic Encephalopathy Score for the detection of minimal hepatic encephalopathy in Korean patients with liver cirrhosis显示文摘 | Yeon Seok Seo Sun Young Yim Jin Yong Jung Chang Ha Kim Jin Dong Kim Bora Keum Hyonggin An Hyung Joon Yim Hong Sik Lee Chang Duck Kim Ho Sang Ryu Soon Ho Um | 2012 | Journal of Gastroenterology and Hepatology2012，，11： | 1 |
| 4 | Arduino-based low-cost electrical load tracking system with a long-range mesh network显示文摘A system that combines the advantage of the long-range(LoRa)communication method and the structural characteristics of a mesh network for an LoRa mesh network-based wireless electrical load tracking system is proposed.The system demonstrates considerable potential in reducing data loss due to environmental factors in farfield wireless energy monitoring.The proposed system can automatically control the function of each node by confirming the data source and eventually adjust the system structure according to real-time monitoring data without manual intervention.To further improve the sustainability of the system in outdoor environments,a standby equipment is designed to automatically ensure the normal operation of the system when the hardware of the base station fails.Our system is based on the Arduino board,which lowers the production cost and provides a simple manufacturing process.After conducting a long-term monitoring of a near-field smart manufacturing process in South Korea and the far-field energy consumption of rural households in Tanzania,we have proven that the system can be implemented in most regions,neither confined to a specific geographic location nor limited by the development of local infrastructure.This system comprises a smart framework that improves the quality of energy monitoring.Finally,the proposed big-data-technology-based power supply policy offers a new approach for prolonging the power supply time of off-grid power plants,thereby providing a guideline for more rural areas with limited power sources to utilize uninterrupted electricity. | Xin-Lin Wang Bora Ha Frank Andrew Manongi Woo-Kyun Jung Yusufu Abeid Chande Jande Sung-Hoon Ahn | 2021 | Advances in Manufacturing2021，9，1： | 1 |
| 5 | Prognosis of hepatitis B‐related liver cirrhosis in the era of oral nucleos(t)ide analog antiviral agents显示文摘 | Chang Ha Kim Soon Ho Um Yeon Seok Seo Jin Yong Jung Jin Dong Kim Hyung Joon Yim Bora Keum Yong Sik Kim Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu | 2012 | Journal of Gastroenterology and Hepatology2012，，10： | 1 |
| 6 | Peptidomimetic small-molecule compounds promoting cardiogenesis of stem cells显示文摘 | Se-Woong Oh Jung Bok Lee Bora Kim Sejin Jeon Min-Kyoung Kim Ki-Hoan Nam Jong-Ryul Ha Mickie Bhatia Goo Taeg Oh Dae-Yong Kim | 2012 | Archives of Pharmacal Research2012，，11： | 1 |
| 7 | Correction to:Arduino-based low-cost electrical load tracking system with a long-range mesh network显示文摘Correction to:Adv.Manuf.http://gffzzd3cc09b8251d45dfs9p5vcx6nnfv06k0b.ffgz.tsg.suse.edu.cn/10.1007/s40436-020-00310-5 In the original publication the first author name is published incorrectly as 'Xin-Lin Wang'.The correct author name should be read as 'Xinlin Wang'.Also,the correct fund note in the acknowledgement section should be 'This research was supported in part by the International S&T Cooperation Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Science,ICT&Future Planning(MSIP)(Grant No.NRF-2017K1A3A9A04013801),and by the Basic Research Lab Program through NRF funded by the MSIT(Grant No.2018R1A4A1059976)'.The correct author name and correct fund note is available in this correction. | Xinlin Wang Bora Ha Frank Andrew Manongi Woo-Kyun Jung Yusufu Abeid Chande Jande Sung-Hoon Ahn | 2021 | Advances in Manufacturing2021，9，4： | 0 |
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