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| 1 | Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice(ob/ob)显示文摘AIM:To investigate the colocalization,density and profile of neuronal areas of enteric neurons in the ileum of male obese mice.METHODS:The small intestinal samples of male mice in an obese group(OG)(C57BL/6J ob/ob)and a control group(CG)(+/+)were used.The tissues were analyzed using a double immunostaining technique for immunoreactivity(ir)of the P2X2 receptor,nitric oxide synthase(NOS),choline acetyl transferase(ChAT)and calretinin(Calr).Also,we investigated the density and profile of neuronal areas of the NOS-,ChAT-and Calrir neurons in the myenteric plexus.Myenteric neurons were labeled using an NADH-diaphorase histochemical staining method.RESULTS:The analysis demonstrated that the P2X2receptor was expressed in the cytoplasm and in the nuclear and cytoplasmic membranes only in the CG.Neuronal density values(neuron/cm2)decreased 31%(CG:6579±837;OG:4556±407)and 16.5%(CG:7796±528;OG:6513±610)in the NOS-ir and calretininir neurons in the OG,respectively(P<0.05).Density of ChAT-ir(CG:6200±310;OG:8125±749)neurons significantly increased 31%in the OG(P<0.05).Neuron size studies demonstrated that NOS,ChAT,and Calr-ir neurons did not differ significantly between the CG and OG groups.The examination of NADH-diaphorase-positive myenteric neurons revealed an overall similarity between the OG and CG.CONCLUSION:Obesity may exert its effects by promoting a decrease in P2X2 receptor expression and modifications in the density of the NOS-ir,ChAT-ir and CalR-ir myenteric neurons. | Márcia Sanae Mizuno Amanda Rabello Crisma Primavera Borelli Bárbara Tavares Schfer Mariana Póvoa Silveira Patricia Castelucci | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 2 | Optically induced anisotropy in photo chromic glasses显示文摘 | BORELLI N F CHODAK J B HARES G B | 1979 | J Appl Phys1979，50，9： | 1 |
| 3 | Islet a- daptive changes to fructose-induced insulin resistance: beta-cell mass, glucokinase, glucose metabolism, and insulin secretion 显示文摘 | MAIZTEHUI B BORELLI MI RASCHIA MA | 2009 | J Endocrinol2009，200，2： | 1 |
| 4 | A silk cardigan inducing asthma 显示文摘 | Borelli S Stern A Wuthrich B | 1999 | Allergy1999，54，8： | 1 |
| 5 | Effect of the length of glass fiber posts on the fracture resistance of restored maxillary central incisors 显示文摘 | Borelli B Sorrentino R Zarone F | 2012 | Am J Dent2012，25，2： | 1 |
| 6 | Sitagliptin prevents the development of metabolic and hormonal disturbances, increased 显示文摘 | Maiztegui B Borelli MI Madrid VG | 2011 | Clin Sci (Lond)2011，120，： | 1 |
| 7 | Evaluating residual dentin thickness following various mandibular anterior tooth preparations for zirconia full-coverage single crowns:an in vitro analysis显示文摘 | Borelli B Sorrentino R Goracci C | 2015 | Int J Periodontics Restorative Dent2015，35，1： | 1 |
| 8 | Islet a- daptive changes to fructose-induced insulin resistance: beta-cell massglucokinase glucose metabolism and insulin secretion 显示文摘 | Maiztegui B Borelli M I Raschia M A | 2009 | J Endocrinol2009，200，2： | 1 |
| 9 | Proliferation and adhesion capability of human gingival fibroblasts onto zirconia,lithium disilicate and felds- pathic veneering ceramic in vitro显示文摘 | Tete S Zizzari VL Borelli B | 2014 | Dent Mater J2014，33，1： | 1 |
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