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| 1 | 抗氧化剂L-乙酰半胱氨酸对大鼠脉冲噪声的保护作用显示文摘目的 研究抗氧化剂L 乙酰半胱氨酸是否能够保护脉冲噪声引起的耳聋。方法 第 1组动物 :8只大鼠暴露在16 0dBSPL 5 0次脉冲噪声。第 2组动物 :10只大鼠同样暴露 16 0dBSPL 5 0次脉冲噪声 ,但在噪声暴露前 1h ,噪声暴露后立刻 ,噪声暴露后 3h ,给予L 乙酰半胱氨酸腹腔内注射 (35 0mg·kg-1,IP)。第 3组动物 :5只给予腹腔注射L 乙酰半胱氨酸 3次 ,注射方法与第 2组相同 ,不暴露脉冲噪声。全部动物通过脑干诱发电位检测听力阈值在噪声前 ,噪声后立刻 ,噪声后 1d ,1,2 ,4wk。结果 第 1组 :比较噪声前和噪声后 ,全部频率有明显听力损失。第 2组 :大鼠暴露同样剂量噪声 ,立刻和 1天后检测ABR阈值与暴露前相比听力损失明显 ,1wk后在 4到 2 0kHz都有听力损失 ,但在 31 5和 4 0kHz已不明显。在 2和 4wk之后 ,各频率听力损失不明显。第 3组 :立刻 ,1d后 ,4wk后测量脑干诱发电位各频率无听力损失。结论 抗氧化剂L 乙酰半胱氨酸能够保护脉冲噪声引起的听力损害。 | 邱建新 童步升 吴开乐 Gran Laurell Erik Borg 段茂利 | 2004 | 中国药理学通报2004，20，7： | 3 |
| 2 | Determination of Lead in Biological Samples by High-resolution Continuum Source Graphite Furnace Atomic Absorption Spectrometry with Direct Solid Sampling显示文摘 | BORGES D G DA SILVA A F WELZ B | 2006 | JAnal at Spectrom2006，21，： | 1 |
| 3 | Suagrcane yellow leaf virus : a novel member of the Luteoviridae that probably arose by inter-species recombination 显示文摘 | Smith G R Borg Z Lockhart B E | 2000 | J Gen Virol2000，81，： | 1 |
| 4 | Plasmas as antennas: Theory, experiment and applications显示文摘 | Borg G G Harris J H Martin N M etal | 2000 | Phys Plasmas2000，7，7： | 1 |
| 5 | Neurotrophins role in depression neurobiology:a review of basic and clinical ev-idence显示文摘 | Neto FL Borges G Torres-Sanchez S | 2011 | Curr Neuropharmacol2011，9，4： | 1 |
| 6 | Line Extraction in 2D Range Images for Mo- bile Robotics 显示文摘 | Borges G Aldon M | 2004 | Journal of Intelligent and Robotic Systems2004，40，： | 1 |
| 7 | Towards a Model for the Determinants of Occupational Stress among Schoolteachers显示文摘 | M G BORG R J RIDING J M FALZON | 1991 | European Journal of Psychology of Education1991，，6： | 1 |
| 8 | Anne tybjerg-hansen ACE gene polymorphism in cardiovascular disease meta-analyses of small and large studies in whites显示文摘 | Birgit Agerholm-larsen Borge G Nordestgaard | 2000 | Atherosclerosis and Lipoproteins2000，20，： | 1 |
| 9 | Characterisation and genetic diversity via REP PCR of Escherichia coli isolates from polluted waters in southern Brazil显示文摘 | Borges LGD Dalla VV Corcao G | 2003 | FEMS Mierobiol Ecol2003，45，： | 1 |
| 10 | Psychophysical Bases of Perceived Exertion显示文摘 | Borg G A | 1982 | Med sci sports exerc1982，14，5： | 1 |
| 11 | Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy显示文摘AIM:To evaluate the potential use of colonoscopy and endoluminal ultrasonic biomicroscopy(eUBM)to track the progression of mouse colonic lesions.METHODS:Ten mice were treated with a single azoxy-methane intraperitoneal injection(week 1)followed by seven days of a dextran sulfate sodium treatment in their drinking water(week 2)to induce inflammationassociated colon tumors.eUBM was performed simultaneously with colonoscopy at weeks 13,17-20 and21.A 3.6-F diameter 40 MHz mini-probe catheter was used for eUBM imaging.The ultrasound mini-probe catheter was inserted into the accessory channel of a pediatric flexible bronchofiberscope,allowing simultaneous acquisition of colonoscopic and eUBM images.During image acquisition,the mice were anesthetized with isoflurane and kept in a supine position over a stainless steel heated surgical waterbed at 37℃.Both eUBM and colonoscopic images were captured and stored when a lesion was detected by colonoscopy or when the eUBM image revealed a modified colon wall anatomy.During the procedure,the colon was irrigated with water that was injected through a flush port on the mini-probe catheter and that acted as the ultrasound coupling medium between the transducer and the colon wall.Once the acquisition of the last eUBM/colonoscopy section for each animal was completed,the colons were fixed,paraffin-embedded,and stained with hematoxylin and eosin.Colon images acquired at the first time-point for each mouse were compared with subsequent eUBM/colonoscopic images of the same sites obtained in the following acquisitions to evaluate lesion progression.RESULTS:All 10 mice had eUBM and colonoscopic images acquired at week 13(the first time-point).Two animals died immediately after the first imaging acquisition and,consequently,only 8 mice were subjected to the second eUBM/colonoscopy imaging acquisition(at the second time-point).Due to the advanced stage of colonic tumorigenesis,5 animals died after the second time-point image acquisition,and thus,only three were subjected to the third eUBM/colonoscopy imaging acquisition(the third time-point).eUBM was able to detect the four layers in healthy segments of colon:the mucosa(the first hyperechoic layer moving away from the mini-probe axis),followed by the muscularis mucosae(hypoechoic),the submucosa(the second hyperechoic layer)and the muscularis externa(the second hypoechoic layer).Hypoechoic regions between the mucosa and the muscularis externa layers represented lymphoid infiltrates,as confirmed by the corresponding histological images.Pedunculated tumors were represented by hyperechoic masses in the mucosa layer.Among the lesions that decreased in size between the first and third time-points,one of the lesions changed from a mucosal hyperplasia with ulceration at the top to a mucosal hyperplasia with lymphoid infiltrate and,finally,to small signs of mucosal hyperplasia and lymphoid infiltrate.In this case,while lesion regression and modification were observable in the eUBM images,colonoscopy was only able to detect the lesion at the first and second time-points,without the capacity to demonstrate the presence of lymphoid infiltrate.Regarding the lesions that increased in size,one of them started as a small elevation in the mucosa layer and progressed to a pedunculated tumor.In this case,while eUBM imaging revealed the lesion at the first time-point,colonoscopy was only able to detect it at the second time-point.All colonic lesions(tumors,lymphoid infiltrate and mucosal thickening)were identified by eUBM,while colonoscopy identified just76%of them.Colonoscopy identified all of the colonic tumors but failed to diagnose lymphoid infiltrates and increased mucosal thickness and failed to differentiate lymphoid infiltrates from small adenomas.During the observation period,most of the lesions(approximately67%)increased in size,approximately 14%remained unchanged,and 19%regressed.CONCLUSION:Combining eUBM with colonoscopy improves the diagnosis and the follow-up of mouse colonic lesions,adding transmural assessment of the bowel wall. | Rossana C Soletti Kelly Z Alves Marcelo AP de Britto Dyanna G de Matos Mnica Soldan Helena L Borges Joo C Machado | 2013 | World Journal of Gastroenterology2013，19，44： | 1 |
| 12 | Application of Plasma Columns to Radiofrequency Antennas显示文摘 | Borg G G Harris J H | 1999 | Applied Physics Letters1999，74，22： | 1 |
| 13 | Psychophysical bases of perceived exertion 显示文摘 | Borg G A | 1982 | Med Sci Sports Exerc1982，14，5： | 1 |
| 14 | Activity and contents of polyphenolic antioxidants in the whole fruit,flesh and peel of three apple cultivars显示文摘 | Vieira F Borges G Copetti C | 2009 | Archivos Latinoameficanos De Nutricion2009，59，1： | 1 |
| 15 | A structural model of the di- mensions of teacher stress 显示文摘 | Boyle GJ Borg M G Baglioni A J | 1995 | British Journal of Educational Psychology1995，65，： | 1 |
| 16 | New protocol of elomiphene citrate treatment in women with hypothalamic amenorrhea显示文摘 | Borges LE Morgante G Musacchio MC | 2007 | Gyneeol Endoerinol2007，23，6： | 1 |
| 17 | Core Self-evaluations : A Predictor Variable for Job Stress显示文摘 | BRUN BORG G S | 2008 | European Psychologist2008，13，2： | 1 |
| 18 | Evaluation of a quantitative realtime PCR for the detection of respiratory syncytial virus in pulmonary diseases显示文摘 | Borg I Rohde G Loseke S | 2003 | Eur Respir J2003，21，6： | 1 |
| 19 | Prevalence of and risk factors for lifetime suicide attempts in the National Comorbidity Survey 显示文摘 | KESSLER R C BORGES G WALTERS E E | 1999 | Arch Gen Psychia1999，56，7： | 1 |
| 20 | C-reactive protein levels during disease exacerbations and infections in systemic lupus erythematosus:a prospective longitudinal study显示文摘 | ter Borg E J Horst G Limburg P C van Rijswijk M H Kallenberg C G | 1990 | J Rheumatol1990，17，： | 1 |
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