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| 1 | Oncogenic driver mutations in non-small cell lung cancer: Past, present and future显示文摘Lung cancer,of which non-small lung cancer is the most common subtype,represents the leading cause of cancer related-death worldwide.It is now recognized that a significant proportion of these patients present alterations in certain genes that drive oncogenesis.In recent years,more of these so-called oncogenic drivers have been identified,and a better understanding of their biology has allowed the development new targeted agents.This review aims to provide an update about the current landscape of driver mutation in non-smallcell lung cancer.Alterations in Kirsten rat sarcoma,epidermal growth factor receptor,MET,anaplastic lymphoma kinase,c-ROS oncogene 1,v-raf murine sarcoma viral oncogene homolog B,neurotrophic receptor tyrosine kinase,human epidermal growth factor 2,neuregulin-1 and rearranged during transfection are discussed,as well as agents targeting these alterations.Current standards of treatment as well as promising future strategies are presented.Currently,more than fifteen targeted agents are food and Drug administration-approved for seven oncogenic drivers in non-small-cell lung cancer,highlighting the importance of actively searching for these mutations.Continuous and future efforts made in defining the biology of each of these alterations will help to elucidate their respective resistance mechanisms,and to define the best treatment strategy and therapeutic sequence. | Mathieu Chevallier Maxime Borgeaud Alfredo Addeo Alex Friedlaender | 2021 | World Journal of Clinical Oncology2021，12，4： | 4 |
| 2 | Force transfer between the plate and the bone:relative importance of the bending stiffness of the screws friction between plate and bone显示文摘 | Cordey J Borgeaud M Perren S | 2000 | Injury2000，31，3： | 1 |
| 3 | Suppressing subordinate reproduction provides benefits to dominants in cooperative societies of meerkats 显示文摘 | Bell M B V Cant M A Borgeaud C | 2014 | Nature Communications2014，5，： | 1 |
| 4 | A study of vegetation cover effects on ERS scatterometer data显示文摘 | Wagner W Lemoine G Borgeaud M | 1999 | IEEE Transactions on Geoscience and Remote Sensing1999，37，2： | 1 |
| 5 | Force transfer between the plate and the bone: relative importance of the bending stiffness of the screws friction between plate and bone显示文摘 | Cordey J Borgeaud M Perren SM | 2000 | Injury2000，31，3： | 1 |
| 6 | Force transfer between the plate and the bone: relative importance of the bending stifi'ness ofthe screws friction between plate and bone显示文摘 | Cordey J Borgeaud M Perren S M | 2000 | Injury2000，31，3： | 1 |
| 7 | Mechanical analysis of the bone to plate interface of the LC-DCP and of the PC-FiXon human femora显示文摘 | Borgeaud M Cordey J Leyvraz PE | 2000 | Injury2000，31，3： | 1 |
| 8 | Theoretical models for polarimetric radar clutter显示文摘 | Borgeaud M Shin R T Kong J A | 1987 | Journal of Electromagnetic Waves and Applications1987，1，1： | 1 |
| 9 | Mechanical analysis of the bone to plate interface of the LC-DCP and of the PC-FiX on human femora 显示文摘 | Borgeaud M Cordey J Leyvraz P E | 2000 | Injury2000，31，3： | 1 |
| 10 | Mechanical analysis of the bone to plate interface of the LC- DCP and of the PC- FIX on human femora显示文摘 | Borgeaud M Cordey J Leyvraz P E | 2000 | Injury2000，31，3： | 1 |
| 11 | Monitoring Soil Moisture over the Canadian Prairies with the ERS Scatterometer显示文摘 | Wagner W Noll J Borgeaud M | 1999 | IEEE Transactions on Geoscience Remote Sensing1999，37，1： | 1 |
| 12 | Monitoring Soil Moisture over the Canadian Prairies with the ERS Scatterometer显示文摘 | Wagner W Noll J Borgeaud M | 1999 | IEEE Transactions on Geoscience Remote Sensing1999，37，1： | 1 |
| 13 | Force transfer between the plate and bone:relative importance of the bending stiffness of the screws friction between plate and bone显示文摘 | Cordey J Borgeaud M Perren SM | 2000 | Injury2000，31，3： | 1 |
| 14 | Force transfer between the plate and the bone: relative importance of the bending stiffness of the screws friction between plate and bone 显示文摘 | Cordey J Borgeaud M Perren SM | 2000 | Injury2000，31，3： | 1 |
| 15 | Interpreting ERS SAR signatures of agricultural crops in Flevoland: 1993-1996显示文摘 | Saich P Borgeaud M | 2000 | IEEE Transactions on Geoscience and Remote Sensing2000，38，2： | 1 |
| 16 | Force transfer between the plate and the bone : relative importance of the bending stiffness of the screws friction between plate and bone 显示文摘 | Cordey J Borgeaud M Perren SM | 2000 | Injury2000，31，3： | 1 |
| 17 | Force transfer between the plate and the bone:relative importance of the bending stiffness of the screws friction between plate and bone显示文摘 | Cordey J Borgeaud M Perren SM | | 0，，3： | 1 |
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